Statins are widely used in the treatment of hypercholesterolemia but also associated with muscle-related adverse effects. Multidrug resistance-associated protein (MRP) 1 and 5 are expressed in the skeletal muscle, where they may regulate intramuscular levels of their substrates. Here, we investigated the transport of various statins by MRP1 and MRP5 with the vesicular transport assay.
View Article and Find Full Text PDFThe level of thyroidectomy-related regret in patients with clinically low-risk papillary thyroid microcarcinoma (PTMC) and the determinants of decision regret are largely unknown. Here, we show that 319 (24.2%) of those who undergo thyroidectomy and 4 (3.
View Article and Find Full Text PDFThe distribution of substitutional aluminum (Al) atoms in zeolites affects molecular adsorbate geometry, catalytic activity, and shape and size selectivity. Accurately determining Al positions has been challenging. We used synchrotron resonant soft x-ray diffraction (RSXRD) at multiple energies near the Al K-edge combined with molecular adsorption techniques to precisely locate "single Al" and "Al pairs" in a commercial H-ZSM-5 zeolite.
View Article and Find Full Text PDFThe ZSM-5 zeolite is the key active component in high-severity fluid catalytic cracking (FCC) catalysts and is routinely activated by phosphorus compounds in industrial production. To date, however, the detailed structure and function of the introduced phosphorus still remain ambiguous, which hampers the rational design of highly efficient catalysts. In this work, using advanced solid-state NMR techniques, we have quantitatively identified a total of seven types of P-containing complexes in P-modified ZSM-5 zeolite and clearly revealed their structure, location, and catalytic role.
View Article and Find Full Text PDFγ-AlO is a crucial catalyst widely used in industrial alcohol dehydration processes. However, the specific nature of its active sites has remained unclear. In this study, we utilize two-dimensional heteronuclear correlation solid-state nuclear magnetic resonance and density functional theory calculations to uncover the active Al sites on the surface of γ-AlO that facilitate ethanol dehydration.
View Article and Find Full Text PDFBackground: To analyze the relationship between endothelial activation and stress index (EASIX) and the occurrence of acute kidney injury (AKI) in critically ill cancer patients.
Methods: Critically ill cancer patients were selected from the Medical Information Mart for Intensive Care IV (MIMIC-IV). Multivariate logistic regression was used to analyze the association between EASIX and the occurrence of AKI in critically ill cancer patients.
Understanding the mechanism of steam-induced dealumination of zeolite catalysts is of high relevance for tuning their performance and stability in multiple industrial processes. A combination of Al and H-H double-quantum single-quantum magic angle spinning nuclear magnetic resonance and diffuse-reflectance ultraviolet-visible spectroscopies identified a preferential dealumination of tetrahedral aluminum sites in H-ZSM-5 zeolites. Framework aluminum atoms facing channels display reactivity toward steam higher than that of those in their intersections.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
December 2024
Ordered polar structures in oxide nanofilms play a pivotal role in the development of nanoelectronic applications. Hitherto, ordered polar structures have been restricted to a limited number of ferroelectric materials, and there is no effective scheme to induce and manipulate ordered polar patterns in centrosymmetric nonpolar nanofilms due to the absence of spontaneous symmetry breaking. Here, we circumvent these limitations by utilizing the wrinkle-induced strain gradient modulation associated with flexoelectricity as a general means of inducing and manipulating ordered polar patterns in nonpolar nanofilms.
View Article and Find Full Text PDFBackground: Females have a higher age-adjusted incidence of Alzheimer's Disease (AD) than males, even when accounting for longer lifespan and, therefore, stand to benefit the most from dementia prevention efforts. As exposure to many modifiable risk factors for dementia begins in mid-life, interventions must be implemented from middle-age. Building cognitive reserve, particularly through stimulating avocational activities and occupational attainment presents a crucial, underexplored, dementia prevention approach for mid-life.
View Article and Find Full Text PDFBackground: Metabolic syndrome (MetS) is associated with a high risk of endometrial cancer (EC). However, its impact on EC progression remains unclear. This meta-analysis examined the association between MetS and survival outcomes in EC patients.
View Article and Find Full Text PDFThe inevitable dealumination process of zeolite Y is closely related to ultrastabilization, enhanced Bro̷nsted acidity, and deactivation throughout its life cycle, producing complex aluminum and acidic hydroxyl species. Most investigations on dehydrated zeolites have focused on the Bro̷nsted acidity of tetra-coordinated Al (Al(IV)) and Lewis acidity associated with tricoordinated Al (Al(III)) sites, which has left the penta-coordinated Al (Al(V)) in dealuminated zeolites scarcely discussed. This is largely due to the oversimplified view of detectable Al(V) as an exclusively extra-framework species with Lewis acidity.
View Article and Find Full Text PDFAlzheimer's Disease (AD) neuropathology start decades before clinical manifestations, but whether risk factors are associated with early cognitive and brain changes in midlife remains poorly understood. We examined whether AD risk factors were associated with cognition and functional connectivity (FC) between the Locus Coeruleus (LC) and hippocampus - two key brain structures in AD neuropathology - cross-sectionally and longitudinally in cognitively healthy midlife individuals. Neuropsychological assessments and functional Magnetic Resonance Imaging were obtained at baseline (N=210), and two-years follow-up (N=188).
View Article and Find Full Text PDFAnatase TiO is a widely used component in photo- and electro-catalysts for water splitting, and the (101) facet of anatase TiO is the most commonly exposed surface. A detailed understanding of the behavior of HO on this surface could provide fundamental insights into the catalytic mechanism. This, however, is challenging due to the complexity of the interfacial environments, the high mobility of interfacial HO, and the interference from outer-layer HO.
View Article and Find Full Text PDFThe low-carbon economy represents a global transformation that encompasses production methods, lifestyles, values, national interests, and the destiny of humanity. As a significant contributor to carbon emissions, China has made a momentous strategic decision on carbon peaking and neutralization, infusing momentum into the global effort to address climate change. The rapid growth of the digital economy offers a fresh approach to achieving the "double carbon" objective and advancing the development of low-carbon transformation.
View Article and Find Full Text PDFRiboflavin (vitamin B) has been proposed as a biomarker for breast cancer resistance protein (BCRP) activity. In recent studies in mice, cynomolgus monkeys, and humans, BCRP-inhibiting drugs increased the plasma concentration of riboflavin. We showed recently that ticagrelor inhibits BCRP and raises the plasma concentrations of the BCRP substrate rosuvastatin in healthy volunteers.
View Article and Find Full Text PDFIntroduction: Long-term motor skill training has been shown to induce anatomical and functional neuroplasticity. World class gymnasts (WCGs) provide a unique opportunity to investigate the effect of long-term intensive training on neuroplasticity. Previous resting-state fMRI studies have demonstrated a high efficient information processing related to motor and cognitive functions in gymnasts compared with healthy controls (HCs).
View Article and Find Full Text PDFMicro-light-emitting diodes (Micro-LEDs) are a new type of display device based on the third-generation semiconductor gallium nitride (GaN) material which stands out for its high luminous efficiency, elevated brightness, short response times, and high reliability. The contact between anode layers and P-GaN is one of the keys to improving the performance of the devices. This study investigates the impact of electrode structure design and optimized annealing conditions on the anode contact performance of devices.
View Article and Find Full Text PDFArtificial sensory systems with synergistic touch and pain perception hold substantial promise for environment interaction and human-robot communication. However, the realization of biological skin-like functional integration of sensors with sensitive touch and pain perception still remains a challenge. Here, a concept is proposed of suspended electronic skins enabling 3D deformation-mechanical contact interactions for achieving synergetic ultrasensitive touch and adjustable pain perception.
View Article and Find Full Text PDFBackground: The sirtuin family is well recognized for its crucial involvement in various cellular processes. Nevertheless, studies on its role in the human endometrium are limited. This study aimed to explore the expression and localization of the sirtuin family in the human endometrium, focusing on sirtuin 3 (SIRT3) and its potential role in the oxidative imbalance of the endometrium in polycystic ovary syndrome (PCOS).
View Article and Find Full Text PDFProg Nucl Magn Reson Spectrosc
November 2023
Solid-state NMR spectroscopy (ssNMR) can provide details about the structure, host-guest/guest-guest interactions and dynamic behavior of materials at atomic length scales. A crucial use of ssNMR is for the characterization of zeolite catalysts that are extensively employed in industrial catalytic processes. This review aims to spotlight the recent advancements in ssNMR spectroscopy and its application to zeolite chemistry.
View Article and Find Full Text PDFAberrant mRNA expression is implicated in uterine corpus endometrial carcinoma (UCEC) oncogenesis and progression. However, effective prognostic biomarkers for UCEC remain limited. We aimed to construct a reliable multi-gene risk model using gene expression profiles.
View Article and Find Full Text PDFWe report the construction of frustrated Lewis pairs (FLPs) in a metal-organic framework (MOF), where both Lewis acid (LA) and Lewis base (LB) are fixed to the backbone. The anchoring of a tritopic organoboron linker as LA and a monotopic linker as LB to separate metal oxide clusters in a tetrahedron geometry allows for the precise control of distance between them. As the type of monotopic LB linker varies, pyridine, phenol, aniline, and benzyl alcohol, a series of 11 FLPs were constructed to give fixed distances of 7.
View Article and Find Full Text PDFDirect determination of the equilibrium adsorption and spectroscopic observation of adsorbent-adsorbate interaction is crucial to evaluate the olefin/paraffin separation performance of porous adsorbents. However, the experimental characterization of competitive adsorption of various adsorbates at atomic-molecular level in the purification of multicomponent gas mixtures is challenging and rarely conducted. Herein, solid-state NMR spectroscopy is employed to examine the effect of co-adsorbed guest adsorbates on the separation of ethylene/ethane mixtures on Mg-MOF-74, Zn-MOF-74 and UTSA-74.
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