Publications by authors named "Fenfang Gao"
Article Synopsis
- - The study investigates a specific case of congenital myasthenia caused by a deletion mutation in the SLC5A7 gene in a Chinese male, characterized by fluctuating limb weakness and confirmed through genetic testing.
- - Both the patient's mother and brother also showed a deletion in exon 9 of the SLC5A7 gene, indicating a hereditary component to this genetic disorder.
- - Findings suggest that mutations in certain exons of the SLC5A7 gene can affect the choline transporter's function, pointing to the need for careful family history assessment and advanced genetic testing in similar cases of myasthenic symptoms.
Background: It is generally acknowledged that the determination of harmful chemical compounds excreted into saliva is useful for assessing their exposure levels. The aim of the present study was to compare the total arsenic and its species in saliva and urine samples collected from the people residing in an arsenic-contaminated area of China and to further verify the feasibility of using salivary arsenic as a new biomarker of arsenic exposure.
Methods: Total arsenic and speciation analyses in urine and saliva samples among 70 residents exposed to arsenic from drinking water in Shanxi, China were carried out by high-performance liquid chromatography-inductively coupled plasma-mass spectrometry (HPLC-ICP/MS).
It is well known that long-term exposure to arsenite leads to human skin cancer, but the underlying mechanisms of carcinogenesis remain obscure. The transcription factor Nrf2-mediated antioxidant response represents a critical cellular defense mechanism; however, emerging data suggest that constitutive activation of Nrf2 is associated with cancer development and chemotherapy resistance. The reasons Nrf2 continuously accumulates in cancer cells remain to be fully understood.
View Article and Find Full Text PDFObjective: To investigate the level of ROS, MDA and SOD in different stages of arsenic-induced neoplastic transformation in human keratinocytes.
Methods: HaCaT human immortalized keratinocytes were continuously exposed to 1.0 μmol/L arsenite for 35 passages.
A fast and reliable HPLC method for the simultaneous separation of anthocyanins and flavonols in lotus petals was developed based on the study of four candidate solvent systems. Fifteen flavonoids were identified by high-performance liquid chromatography with photodiode array detection/mass spectrometry. Among them, two anthocyanins and nine flavonols were discovered in lotus petals for the first time.
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