Publications by authors named "Fenbei Chen"
Article Synopsis
- Helicobacter pylori is a major carcinogenic pathogen linked to stomach cancer, known for its high prevalence and resistance, making treatment challenging.
- Researchers used a graph neural network model to identify a promising new compound, a berberine derivative named 8, which effectively inhibits both drug-susceptible and resistant H. pylori strains.
- The compound 8 shows strong gastric retention and performs comparably to standard triple therapies without affecting intestinal bacteria, positioning it as a potential novel treatment for resistant H. pylori infections.
The COVID-19 pandemic highlights the urgent need to develop effective small-molecule antivirals. Thirty-three novel biaryl amide derivatives were synthesized and evaluated for anti-coronaviral activity. Some significant SARs were uncovered and the intensive structure modifications led to the most active compounds 8b and 8h.
View Article and Find Full Text PDFEvaluation and mechanism study of Pien Tze Huang against EV-A71 infection.
Front Pharmacol
October 2023
Article Synopsis
- Hand, foot, and mouth disease (HFMD) caused by enterovirus A71 (EV-A71) currently has no specific treatments, but Pien Tze Huang (PZH) shows promise in inhibiting the virus's replication.
- Research indicates that PZH significantly reduces viral protein expression and viral loads in cells and protects mice from EV-A71 infection, outpacing the effects of the common antiviral drug Ribavirin.
- A study of the underlying mechanisms suggests PZH may work by suppressing certain cellular pathways (PI3K/AKT/mTOR and NF-κB), indicating its potential as a therapeutic option for managing EV-A71 infections.