Obstacles to Medication Adherence for Patients with Inflammatory Bowel Disease: A Qualitative Study in East China.

Purpose: To identify the factors impacting medication non-adherence in patients with inflammatory bowel disease (IBD) in China, and to provide a reference for effective interventions.

Patients And Methods: Individual semi-structured interviews were conducted between December 2020 and July 2021 in four tertiary hospitals in East China. A conventional content analysis method was used in data analysis to extract themes and sub-themes in IBD Patients with poor medication adherence.

The effects of phosphorus on the fate and transformation of sediment-associated cadmium from river sediments.

The coexistence of phosphorus (P) and cadmium (Cd) in river sediments poses a significant challenge for remediating these contaminants in aquatic environments, given the ongoing debates regarding their interactions. This study aimed to elucidate the impact of water-soluble phosphorus (PO) on the fate and transformation of sediment-associated Cd under varying conditions. The findings revealed that the impact of PO on the release of sediment-associated Cd depends on the presence or absence of cations such as Ca and Mg, with Ca exerting a more pronounced effect than Mg.

The value of chromosome instability detected by low-pass whole-genome sequencing in preoperative prediction of sentinel lymph node metastasis in breast cancer.

Background: Breast cancer is a malignancy characterized by chromosomal instability (CIN). This study aimed to examine the potential diagnostic value of chromosomal instability, detected by low-pass whole-genome sequencing (LPWGS), in the preoperative evaluation of sentinel lymph node metastasis (SLNM) in breast cancer.

Methods: A retrospective investigation of clinical records from 29 patients with breast cancer revealed two distinct groups based on sentinel lymph node biopsy (SLNB) results: the SLN metastasis group (24 cases) and the SLN non-metastasis group (five cases).

On-Line Measurement of Tracking Poses of Heliostats in Concentrated Solar Power Plants.

The tracking pose of heliostats directly affects the stability and working efficiency of concentrated solar power (CSP) plants. Due to occlusion, over-exposure, and uneven illumination caused by mirror reflection, traditional image processing algorithms showed poor performances on the detection and segmentation of heliostats, which impede vision-based 3D measurement of tracking poses of heliostats. To tackle this issue, object detection using deep learning neural networks are exploited.

Significantly Enhanced Oxidation Resistance and Electrochemical Performance of Hydrothermal TiCT MXene and Tannic Acid Composite for High-Performance Flexible Supercapacitors.

The electrochemical performances of TiCT MXene are severely restricted by the easy oxidation and restacking. Herein, tannic acid (TA) is introduced into TiCT dispersion, and the mixed dispersion is further subjected to a simple hydrothermal treatment to prepare the hydrothermal TiCT and TA composite (h-TiCT@h-TA). Due to the decomposition of TA into gallic acid (GA), hydrothermal TA (h-TA) is a mixture of TA and GA.

The toxicity of cisplatin derives from effects on renal organic ion transporters expression and serum endogenous substance levels.

Acute kidney injury (AKI) is a worldwide public health problem with high morbidity and mortality. Cisplatin is a widely used chemotherapeutic agent for treating solid tumors, but the induction of AKI restricts its clinical application. In this study, the effect of cisplatin on the expression of organic ion transporters was investigated through in vivo and in vitro experiments.

Preparation of a Highly Flame-Retardant Urea-Formaldehyde Resin and Flame Retardance Mechanism.

Urea-formaldehyde (UF) resin is the most widely used adhesive resin. However, it is necessary to improve its flame-retardant performance to expand its applications. In this study, exploiting electrostatic interactions, anionic phytic acid and cationic chitosan were combined to form a bio-based intumescent flame-retardant, denoted phytic acid-chitosan polyelectrolyte (PCS).

Improving Lower Limb Function and Frailty in Frail Older Patients with Acute Myocardial Infarction After Percutaneous Coronary Intervention: A Randomized Controlled Study of Neuromuscular Electrical Stimulation.

Background: A global public health problem, frailty is closely associated with poor prognosis after percutaneous coronary intervention (PCI) in older patients with acute myocardial infarction (AMI). Although exercise intervention is the most commonly used method to reverse and alleviate frailty, its application is restricted in patients with acute myocardial infarction following PCI due to cardiovascular instability and autonomic imbalance. Consequently, there is a need for a new practical intervention to address frailty syndrome in these patients.

Simultaneous natural attenuation of Cr(VI) and nitrate in the hyporheic zone sediments from an upstream tributary of the Jinsha River in the Sichuan Basin.

The coexistence of hexavalent chromium (Cr(VI)) and nitrate (NO) in groundwater and surface water presents a considerable challenge for the natural attenuation of these two contaminants because their interactions in nature remain contentious. This study investigated the interplay between Cr(VI) and NO in hyporheic zone (HZ) sediments by integrating Cr(VI) reduction kinetics, NO transformation, microbial community structure, and a three-rate model. The concurrent natural attenuation of Cr(VI) and NO in the sediments was significantly influenced by their initial concentrations and redox conditions.

Preparation of a Flame-Retardant Curing Agent Based on Phytic Acid-Melamine Ion Crosslinking and Its Application in Wood Coatings.

To broaden the applications of wood, it is necessary to prepare flame-retardant coatings that can protect wood substrates during combustion. In this study, a bio-based, intumescent, flame-retardant phytic acid-melamine polyelectrolyte (PM) was prepared using phosphorus-rich biomass phytic acid and nitrogen-rich melamine as raw materials through an ion crosslinking reaction. Subsequently, a series of bio-based, flame-retardant wood coatings were prepared by optimizing the structure of urea-formaldehyde resin with the addition of melamine, sodium lignosulfonate, and PM as a flame-retardant curing agent.

Intention to have a third child among millennial parents with two children in eastern China: A cross-sectional survey.

Aim: This Study Aimed to Assess the Intention to Have a Third Child among Millennial Parents (25-40 years old) with Two Children in a City in Eastern China and to Explore the Influencing Factors Related to Fertility Intention.

Design: A cross-sectional design study.

Methods: A convenience sampling method was used to enrol participants of childbearing age who visited two tertiary hospitals in Hang zhou, a city in eastern China, from June 2021 to March 2022.

Near-infrared fluorescent probe for the imaging of viscosity in fatty liver mice and valuation of drug efficacy.

Fatty liver disease affects at least 25 percent of the population worldwide and is a severe metabolic syndrome. Viscosity is closely related to fatty liver disease, so it is urgent to develop an effective tool for monitoring viscosity. Herein, a NIR fluorescent probe called MBC-V is developed for imaging viscosity, consisting of dimethylaniline and malonitrile-benzopyran.

High-Performance Zinc-Ion Hybrid Supercapacitor from Guilin Sanhua Liquor Lees-Derived Carbon Materials.

Aqueous zinc-ion hybrid supercapacitors (ZHSCs) have attracted considerable attention because they are inexpensive and safe. However, the inadequate energy densities, power densities, and cycling performance of current ZHSC energy-storage devices are impediments that need to be overcome to enable the further development and commercialization of this technology. To address these issues, in this study, we prepared carbon-based ZHSCs using a series of porous carbon materials derived from Sanhua liquor lees (SLPCs).

Recruitment or activation of mast cells in the liver aggravates the accumulation of fibrosis in carbon tetrachloride-induced liver injury.

Liver diseases caused by viral infections, alcoholism, drugs, or chemical poisons are a significant health problem: Liver diseases are a leading contributor to mortality, with approximately 2 million deaths per year worldwide. Liver fibrosis, as a common liver disease characterized by excessive collagen deposition, is associated with high morbidity and mortality, and there is no effective treatment. Numerous studies have shown that the accumulation of mast cells (MCs) in the liver is closely associated with liver injury caused by a variety of factors.

Role of liver FGF21-KLB signaling in ketogenic diet-induced amelioration of hepatic steatosis.

Background: The effectiveness of ketogenic diet (KD) in ameliorating fatty liver has been established, although its mechanism is under investigation. Fibroblast growth factor 21 (FGF21) positively regulates obesity-associated metabolic disorders and is elevated by KD. FGF21 conventionally initiates its intracellular signaling via receptor β-klotho (KLB).

A maternal low-protein diet impaired glucose metabolism and altered the lncRNA profiles of islets in adult offspring.

A maternal low-protein diet during pregnancy can increase children's susceptibility to diabetes mellitus in adulthood. However, whether long noncoding RNAs (lncRNAs) in islets participate in the development of diabetes in adult offspring following maternal protein restriction is not fully understood. Female mice were fed a low-protein (LP) diet or control diet throughout gestation and lactation.

Unveiling the destabilization of sp and sp bonds in transition metal-modified borohydrides to improve reversible dehydrogenation and rehydrogenation.

Borohydrides offer promise as potential carriers for hydrogen storage due to their high hydrogen concentration. However, the strong chemical bonding within borohydrides poses challenges for efficient hydrogen release during usage and restricts the re-hydrogenation process when attempting to regenerate the material. These high thermodynamic and kinetic barriers present obstacles in achieving reversible de-hydrogenation and re-hydrogenation of borohydrides, impeding their practical application in hydrogen storage systems.

TRIM56 protects against nonalcoholic fatty liver disease by promoting the degradation of fatty acid synthase.

Nonalcoholic fatty liver disease (NAFLD) encompasses a disease continuum from simple steatosis to nonalcoholic steatohepatitis (NASH). However, there are currently no approved pharmacotherapies for NAFLD, although several drugs are in advanced stages of clinical development. Because of the complex pathophysiology and heterogeneity of NAFLD, the identification of potential therapeutic targets is clinically important.

BML-111, the agonist of lipoxin A4, suppresses epithelial-mesenchymal transition and migration of MCF-7 cells regulating the lipoxygenase pathway.

Aberrant epithelial-mesenchymal transition (EMT) and migration frequently occur during tumour progression. BML-111, an analogue of lipoxin A, has been implicated in inflammation in cancer research. Methods: 3-(4,5-Dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay, western blot, Reverse Transcription Polymerase Chain Reaction (RT-PCR), transwell assay, immunofluorescence, and immunohistochemistry were conducted in this study.

The value of hypersensitivity quantitative fecal immunochemical test in early colorectal cancer detection.

At present, both the incidence and mortality rates of colorectal cancer are on the rise, making early screening a crucial tool in reducing the fatality rate. Although colonoscopy is the recommended method according to the guidelines, compliance tends to be poor. The fecal immunochemical test (FIT), a new technology that uses latex immunoturbidimetry to detect fecal blood, offers high specificity and sensitivity.

CRD-BP as a Tumor Marker of Colorectal Cancer.

The National Cancer Center published a comparative report on cancer data between China and the United States in the Chinese Medical Journal, which shows that colorectal cancer (CRC) ranks second in China and fourth in the United States. It is worth noting that since 2000, the case fatality rate of CRC in China has skyrocketed, while the United States has gradually declined. Finding tumor markers with high sensitivity and specificity is our primary goal to reduce the case fatality rate of CRC.

Characteristics of amino acid metabolism in colorectal cancer.

In recent years, metabolomics research has become a hot spot in the screening and treatment of cancer. It is a popular technique for the quantitative characterization of small molecular compounds in biological cells, tissues, organs or organisms. Further study of the tumor revealed that amino acid changes may occur early in the tumor.

Hydrogen Peroxide Electrochemical Sensor Based on Ag/Cu Bimetallic Nanoparticles Modified on Polypyrrole.

Due to the strong oxidizing properties of HO, excessive discharge of HO will cause great harm to the environment. Moreover, HO is also an energetic material used as fuel, with specific attention given to its safety. Therefore, it is of great importance to explore and prepare good sensitive materials for the detection of HO with a low detection limit and high selectivity.