CPEB4, an RNA-binding protein that regulates the translational efficiency of target genes, has been implicated in playing dual roles in tumor progression across multiple cancer types. This study aims to investigate the role of CPEB4 in head and neck squamous cell carcinoma (HNSCC), particularly focusing on nasopharyngeal carcinoma. Differentially expressed proteins associated with CPEB4 were identified using iTRAQ-based proteomics.
View Article and Find Full Text PDFBackground: traumatic brain injury (TBI) is irreversible brain damage, leading to inflammation and cognitive dysfunction. Microglia involved in the inflammatory response after TBI. The gut microbiota, known as the body's "second brain," regulates neurogenesis and immune responses, but its precise role in regulating TBI remains unclear.
View Article and Find Full Text PDFBackground: Transcatheter closure of perimembranous ventricular septal defects in children is a highly effective procedure, but it can result in tricuspid regurgitation (TR). The associated risk factors and long-term outcomes of TR following the procedure are not well understood.
Methods And Results: This retrospective study included 1343 pediatric patients (age, 4.
The escalating environmental pollution, coupled with the degradation of the ozone layer, has led to an increase in ultraviolet radiation (UV) at the Earth's surface. There is also a growing accumulation of pesticide residues in the environment. These stressors are exerting a profound impact on insect populations.
View Article and Find Full Text PDFBackground And Aims: The use of neuromuscular blocking agents (NMBAs) in tracheal intubation is widely accepted in anesthetic induction, but adverse effects are possible. We performed a systematic review and meta-analysis to compare influence of use and nonuse of NMBAs on incidence of laryngeal complications and intubating conditions in surgical patients.
Methods: We searched PubMed, Web of Science, Embase, and Cochrane Library for randomized controlled trials comparing use of NMBAs with either placebo or no treatment for oral tracheal intubation in adult patients under general anesthesia.
Front Med (Lausanne)
February 2025
Objective: To visualize and analyze the trends and hotspots of efferocytosis and inflammation via bibliometric methods.
Methods: Relevant articles and reviews from 2006 to 2023 were retrieved from the Web of Science Core Collection. The data were processed with CiteSpace, and some graphs were generated with Microsoft Excel (version 2016), VOSviewer, Scimago Graphica, Bibliometrix and R Studio.
The cell and mitochondria dual-targeting nanocapsules reported here could exacerbate tumor hypoxia to activate a hypoxia-activated drug, tirapazamine, producing benzotriazinyl radicals and ˙OH, which are capable of killing tumor cells DNA damage. In addition, mitochondrial dysfunction can result from the accumulation of ˙OH. This chain reaction triggers a surge in ROS that can effectively increase the therapeutic efficiency of the nanocapsules.
View Article and Find Full Text PDFInt J Numer Method Biomed Eng
February 2025
Acute type A aortic dissection (ATAAD) is a life-threatening aortic emergency with high mortality. Currently, hemiarch replacement (HAR) and total arch replacement (TAR) are the primary surgeries for ATAAD, but their long-term outcomes remain debated, possibly due to the influence of clinical factors in multicenter studies. This study aims to evaluate the long-term outcomes of HAR and TAR by in silico analysis, mitigating the impact of clinical factors.
View Article and Find Full Text PDFRheumatoid arthritis (RA) is still a healthcare challenge, although current therapeutic strategies have substantially improved its clinical outcomes. The development of novel biomarkers and treatments can increase the likelihood of identification and disease remission in RA patients, especially for patients with seronegative RA and difficult-to-treat RA (D2T RA). Circular RNAs (circRNAs), a novel non-coding RNA species, have been reported to play crucial roles in various biological process of RA.
View Article and Find Full Text PDFEndometritis in dairy cows significantly impacts their reproductive performance. However, its underlying mechanisms remain unclear. Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit-alpha (HADHA) is known to regulate the occurrence of various diseases, but its role in bovine endometritis is poorly understood.
View Article and Find Full Text PDFBiomech Model Mechanobiol
February 2025
This study aimed to investigate the relationship between regional elastic modulus and corresponding hemodynamic indices of healthy aortic arch. Porcine aortic arches (n=18) were obtained from a local abattoir and divided into 24 regions along axial and circumferential directions. Regional elastic modulus was measured by indentation tests, and elastic fiber content was assessed using Elastica van Gieson (EVG) staining.
View Article and Find Full Text PDFEndometritis in dairy cows involves complex molecular regulatory mechanisms. Therefore, uncovering the molecular regulatory mechanisms of endometritis in dairy cows is crucial to understand its development, prevention, and treatment. This study aimed to screen and validate key genes associated with endometritis using transcriptome sequencing of blood samples and previously obtained metabolomic sequencing data.
View Article and Find Full Text PDFObjectives: This study aimed to explore the characteristics, overall anxiety and depression status, and influencing factors of only-child and non-only-child students by examining a medical student population in the post-COVID-19 era.
Study Design: This study was a cross-sectional design.
Methods: An online questionnaire survey was administered among medical students.
Rheumatoid arthritis (RA) is an autoimmune disease with destructive arthritis as its main clinical manifestation, which is a major cause of disability. It is very important to formulate and update a guideline for the diagnosis and treatment of RA that adhere to international guideline development standards and can be applied to clinical practice in China. This guideline is endorsed and developed by the National Clinical Research Center for Dermatologic and Immunologic Diseases, collaborated with Rheumatologists Branch of Chinese Medical Doctor Association, Rheumatology Rehabilitation Branch of Chinese Association of Rehabilitation Medicine, Rheumatology Branch of Chinese Research Hospital Association, and Rheumatology Branch of Beijing Association of Holistic Integrative Medicine, based on grading of recommendations assessment, development and evaluation (GRADE) and reporting items for practice guidelines in healthcare (RIGHT).
View Article and Find Full Text PDFObjectives: Comorbidity prediction models have been demonstrated to offer more comprehensive and accurate predictions of death risk compared to single indices. However, their application in China has been limited, particularly among maintenance hemodialysis (MHD) patients. Therefore, the objective of this study was to evaluate the utility of comorbidity index models in predicting mortality risk among Chinese MHD patients.
View Article and Find Full Text PDFBackground: Perimembranous ventricular septal defect (PMVSD) is a prevalent congenital heart disease, presenting challenges in predicting spontaneous closure, which is crucial for therapeutic decisions. Existing models mainly rely on structured echocardiographic parameters or restricted data. This study introduces an artificial intelligence (AI)-based model, which uses natural language processing (NLP) and machine learning with the aim of improving spontaneous closure predictability in PMVSD.
View Article and Find Full Text PDFBackground And Aims: Nasogastric tube decompression (NGTD) has been a standard practice following endoscopic submucosal dissection (ESD) for early gastric cancers (EGCs) in clinical settings for several years. Nevertheless, there remains a dearth of research assessing the efficacy of NGTD in preventing delayed bleeding after ESD.
Methods: From January 2021 to December 2022, eligible patients who underwent gastric ESD for EGCs were categorized into two groups: NGTD group and no NGTD group.
Regeneration of functional bone tissue relies heavily on achieving adequate vascularization in engineered bone constructs following implantation. This process requires the close integration of osteogenesis and angiogenesis. Cell-free fat extract (CEFFE or FE), a recently emerging acellular fat extract containing abundant growth factors, holds significant potential for regulating osteo-angiogenic coupling and promoting regeneration of vascularized bone tissue.
View Article and Find Full Text PDFThe damage caused by Megalurothrips usitatus, a common pest, has significantly affected the Chinese vegetable industry. The inappropriate application of chemical pesticides has caused M. usitatus to become highly resistant to conventional insecticides.
View Article and Find Full Text PDFThis study investigates the effectiveness of Azvudine and nirmatrelvir-ritonavir (Paxlovid) in treating COVID-19 pneumonia through an analysis of real-world clinical data. We retrospectively collected data from COVID-19 patients hospitalized at the Second Xiangya Hospital of Central South University between December 21, 2022, and January 18, 2023. Using kernel density estimation, box-and-whisker plots, and Schoenfeld residual plots, we evaluated the transition of patients to negative status and assessed factors such as age, disease severity, and treatment effects.
View Article and Find Full Text PDFRetinal vein occlusion (RVO) is a serious vascular condition that impairs vision due to retinal endothelial cell injury and apoptosis. This study aimed to identify key molecular pathways and therapeutic targets involved in RVO pathogenesis. Transcriptomic analysis of the retinal tissues from a mouse RVO model was performed to identify differentially expressed genes and co-expression modules associated with RVO.
View Article and Find Full Text PDFWorld J Clin Cases
November 2024
Background: (SGSP) is a rare pathogen responsible for infant sepsis and meningitis and is potentially overlooked because it is not included in routine group B streptococcal screenings. Hence, we present a case of SGSP-induced infant meningitis and sepsis, accompanied by bronchopneumonia induced by multidrug-resistant (MRSA), providing insights into the identification, management, and prognosis of this bacterial infection.
Case Summary: A 45-day-old female infant presented with two episodes of high fever (maximum temperature: 39.