Publications by authors named "Fen L Hew"

Article Synopsis
  • - The study aims to create a consensus in the Asia-Pacific region on long-term management and sequential therapy for osteoporosis, focusing on effective fracture prevention through individualized treatment strategies.
  • - A panel of experts analyzed current literature and expert opinions, resulting in 12 key recommendations, such as using anabolic agents for high fracture risk patients and switching to antiresorptive agents post-anabolic therapy if needed.
  • - The findings offer a cost-effective framework for osteoporosis management, emphasizing shared decision-making and integration of local healthcare systems to enhance patient care in the Asia-Pacific region.
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Unlabelled: Fracture risk stratification is crucial in countries with limited access to bone density measurement. 24.8% women were in the high-risk category while 30.

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Article Synopsis
  • The Clinical Practice Guidelines aim to provide evidence-based recommendations for healthcare providers dealing with postmenopausal osteoporosis (OP) screening, diagnosis, and management.
  • A comprehensive literature review from 2014 onwards helped update the guidelines by formulating key clinical questions and evaluating relevant studies.
  • Recommended management includes assessing fracture risk, implementing non-pharmacological measures (like calcium intake and exercise), and choosing pharmacological treatments based on the patient's risk level, with regular assessments to adjust treatment as necessary.
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Objective: This study aimed to determine the prevalence of vertebral fractures (VF) in a selected urban population in Malaysia and to explore possible variables associated with VF in the study population.

Methods: A cross-sectional study involving community-living, healthy subjects aged between 45-90 years from the state of Selangor, Malaysia, were invited to attend a bone health check-up. Subjects with diseases known to affect bone metabolism or were on treatment for osteoporosis (OP) were excluded.

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Objectives: To determine the prevalence of osteopenia (OPe) and osteoporosis (OP) in an urban adult population in Malaysia, and to compare the change in the prevalence when using a Caucasian compared to an Asian reference range.

Methods: A cross-sectional random sample of the population aged between 45 and 90 years from the state of Selangor, Malaysia, was invited to attend a bone health check-up. Participants with diseases known to affect bone metabolism or who were on treatment for OP were excluded.

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Objectives: Hip fracture is a major public health problem. Earlier studies projected that the total number of hip fracture will increase dramatically by 2050, and most of the hip fracture will occur in Asia. To date, only a few studies provided the updated projection, and none of them focused on the hip fracture projection in Asia.

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In this article the name of the sixth author, E. Michael Lewiecki was rendered incorrectly. The publisher regrets this error and apologizes for the inconvenience caused.

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Article Synopsis
  • The Fracture Liaison Service (FLS) Consensus Meeting, held on October 14, 2017, in Taiwan, aimed to review and establish best practices for fracture prevention and management in the Asia-Pacific region, supported by international organizations.
  • Experts concluded that the 13 Best Practice Framework (BPF) standards were mostly relevant for the region, needing only minor adjustments to suit local healthcare settings.
  • Key recommendations included enhancing patient education and increasing public communication about FLSs to improve their effectiveness and accessibility in the area.
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Objective: Following an osteoporotic fracture, pharmacological treatment is recommended to increase bone mineral density and prevent future fractures. However, the rate of starting treatment after an osteoporotic hip fracture remains low. The objective of this study was to survey the treatment rate following a low-trauma hip fracture at a tertiary private hospital in Malaysia over a period of 5 years.

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Article Synopsis
  • This Clinical Guidance focuses on helping practitioners assess and manage glucocorticoid-induced osteoporosis (GIO) by utilizing evidence-based recommendations.
  • A systematic literature review was conducted to update treatment guidelines from 2012, emphasizing early intervention for patients starting glucocorticoids, especially within the first 3-6 months when fracture risk rises.
  • Bisphosphonates are recommended as the primary treatment for GIO, particularly in post-menopausal women and older men, while younger individuals should only receive them if they have existing fractures or are at very high risk.
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Article Synopsis
  • The Clinical Guidance aims to assist healthcare practitioners in effectively assessing, diagnosing, and managing osteoporosis (OP) based on the best available evidence.
  • A comprehensive literature review, updating information from 2012, focused on identifying effective diagnostic and treatment strategies for both postmenopausal and male OP, highlighting the importance of using fracture risk assessment tools alongside bone density measurements.
  • Key recommendations include maintaining adequate calcium and vitamin D intake while emphasizing that pharmacological therapies, particularly anti-resorptives, are essential for confirmed OP, requiring regular assessment and adjustment of treatment plans for patients.
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Aim: This Clinical Guidance is aimed to help practitioners assess, diagnose and manage their patients with osteoporosis (OP), using the best available evidence.

Methods: A literature search using PubMed (MEDLINE) and The Cochrane Library identified all relevant articles on OP and its assessment, diagnosis and treatment, from 2005, to update from the previous edition published in 2006. The studies were assessed and the level of evidence assigned; for each statement, studies with the highest level of evidence were used to frame the recommendation.

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