Publications by authors named "Femke De Meyer"
Article Synopsis
- CARD14 is a protein that plays a key role in activating NF-ĸB signaling and inflammatory gene expression in skin cells, and mutations in CARD14 are linked to psoriasis and other skin conditions.
- Research using affinity purification and mass spectrometry identified polo-like kinase 1 (PLK1) as a new binding partner of CARD14, connecting through a specific region rather than its known CARD domain.
- The psoriasis-related CARD14(E138A) variant recruits PLK1 to signaling complexes in skin cells and altering this binding site enhances inflammatory signaling, suggesting that PLK1 serves as a negative regulator in CARD14’s activity.
Linear ubiquitination is an important post-translational modification regulating the activation of numerous proinflammatory signalling mediators. Deregulated linear ubiquitination has been implicated in the pathogenesis of several inflammatory and autoimmune diseases. In this issue, Miao et al.
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