Publications by authors named "Feltes G"
Article Synopsis
- Researchers studied 1,729 patients with coronary artery aneurysms (CAAs) to understand their clinical characteristics and predict outcomes, using data from an international registry across 9 countries.
- The majority of patients were male (78.6%) averaging 66 years old, with significant cardiovascular issues such as coronary artery disease (85.8%) and a median of 1 aneurysm per patient, primarily affecting the left anterior descending artery.
- During a median follow-up of about 45 months, 21.9% of patients died, and 37.1% experienced major adverse cardiovascular events; factors like age, diabetes, and kidney disease were linked to worse outcomes.
Numerous cases of myocarditis related to mRNA vaccines for COVID-19 have recently been described, usually in young men. Long-term evolutive cardiac magnetic resonance imaging (CMR) data are lacking. We describe four consecutive cases of COVID-19 vaccine-induced myocarditis.
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- * Researchers analyzed data from the HOPE-2 registry, examining 2382 patients discharged alive and tracking their mortality and long-term COVID-19 symptoms.
- * Findings reveal that patients with elevated troponin levels face higher mortality rates and are more likely to experience lasting cardiovascular issues, such as fatigue and dyspnea, after discharge.
Count traits are usually explored in livestock breeding programs, and they usually do not fit into normal distribution, requiring alternatives to adjust the phenotype to estimate accurate genetic parameters and breeding values. Alternatively, distribution such as Poisson can be used to evaluate count traits. This study aimed to compare and discuss the genetic evaluation for oocyte and embryo counts considering Gaussian (untransformed variable - LIN; transformed by logarithm - LOG; transformed by Anscombe - ANS) and Poisson (POI) distributions.
View Article and Find Full Text PDFIdentifying and selecting genotypes tolerant to heat stress might improve reproductive traits in dairy cattle, including oocyte and embryo production. The temperature-humidity index (THI) was used, via random regression models, to investigate the impact of heat stress on genetic parameters and breeding values of oocyte and embryo production in Gir dairy cattle. We evaluated records of total oocytes (TO), viable oocytes (VO), cleaved embryos (CE), and viable embryos (VE) from dairy Gir donors.
View Article and Find Full Text PDFUnlabelled: Chronic Fatigue Syndrome (CFS) is a serious, clinical, long-term condition with an unclear etiology and a difficult diagnosis. Our aim is to propose an objective physiological parameter (Functional Limitation Index, FLI) that describes the degree of functional impairment to support clinical suspicion.
Materials And Methods: We consecutively included all CFS patients who consulted in the Exercise Physiology Department at our hospital, a dedicated referral unit for CFS, from 2009 to 2022.
This study presents a comprehensive literature review that investigates the distinctions between true and false cinnamon. Given the intricate compositions of essential oils (EOs), various discrimination approaches were explored to ensure quality, safety, and authenticity, thereby establishing consumer confidence. Through the utilization of physical-chemical and instrumental analyses, the purity of EOs was evaluated via qualitative and quantitative assessments, enabling the identification of constituents or compounds within the oils.
View Article and Find Full Text PDFThe risk of recurrence in takotsubo syndrome (TTS) appears to be low, although previous studies have shown conflicting results and factors associated with recurrences are unclear. The aim of this study is to evaluate the incidence and predictors of TTS recurrences. Adult patients included in the Spanish Multicenter REgistry of TAKOtsubo syndrome (RETAKO) between January 2003 and September 2019 were identified.
View Article and Find Full Text PDFBackground: Concern has risen about the effects of COVID-19 in interstitial lung disease (ILD) patients. The aim of our study was to determine clinical characteristics and prognostic factors of ILD patients admitted for COVID-19.
Methods: Ancillary analysis of an international, multicenter COVID-19 registry (HOPE: Health Outcome Predictive Evaluation) was performed.
Article Synopsis
- Patients with diabetes mellitus (DM) experience a higher long-term mortality rate post-COVID-19 compared to those without DM.
- Among the studied symptoms, diabetics showed fewer cardiovascular complaints but a higher incidence of psychiatric issues like paranoia, and more respiratory complications as evidenced by abnormal spirometry.
- Rates of readmission and reinfection after COVID-19 were similar for both diabetic and non-diabetic patients, indicating that the presence of diabetes does not significantly impact these outcomes.
Article Synopsis
- Heart disease significantly worsens outcomes for COVID-19 survivors, leading to higher rates of post-COVID complications and increased mortality.
- In a study involving over 7,000 patients, those with heart disease were generally older with more health issues compared to those without, showing a 2.63 times higher risk of death.
- The research highlights that vaccination against COVID-19 offers substantial protection, drastically lowering the risk of mortality for patients with pre-existing heart conditions.
Article Synopsis
- The study investigates the effects of beta-blocker therapy on long-term outcomes for patients who have recovered from Takotsubo syndrome (TTS), a condition that can be triggered by stress and involves temporary heart dysfunction.
- Researchers analyzed data from 970 TTS survivors in Spain, assessing whether those treated with beta-blockers had different rates of mortality and TTS recurrence compared to those who were not treated.
- Results showed no significant differences in survival or recurrence rates between patients on beta-blockers and those not on them, suggesting that beta-blockers may not be beneficial for improving long-term outcomes in TTS patients.
The objective of this study was to evaluate the impact of the reduction in the number of test-day records per lactation on genetic parameters of test-day milk yield (TDMY) and the reliability of estimated breeding values for 305-day milk yield in Holstein cattle. Estimates of genetic parameters and breeding values were performed using the animal model of random regression and adjustment of the Legendre polynomial (fourth order). When comparing sires with the same number of daughters, greater reliability was found in the subpopulations with the highest number of milk test-day records per lactation per cow.
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- Most COVID-19 research focuses on hospitalized patients, leaving the impact of prior oral anticoagulation (OAC) therapy before admission understudied.
- Analyzing data from the HOPE COVID-19 Registry, the study compared outcomes between hospitalized patients who had or hadn’t used OAC prior to their admission.
- Results indicated that patients on prior OAC faced a higher risk of mortality and adverse outcomes than those without OAC, with no significant differences between types of OAC used (VKAs vs. DOACs).
Patients with sepsis with a concomitant coronavirus (COVID-19) infection are related to a high morbidity and mortality rate. We investigated a large cohort of patients with sepsis with a concomitant COVID-19, and we developed a risk score for the estimation of sepsis risk in COVID-19. We conducted a sub-analysis from the international Health Outcome Predictive Evaluation Registry for COVID-19 (HOPE-COVID-19-Registry, NCT04334291).
View Article and Find Full Text PDFBackground: Previous works seem to agree in the higher mortality of cancer patients with COVID-19. Identifying potential prognostic factors upon admission could help identify patients with a poor prognosis.
Methods: We aimed to explore the characteristics and evolution of COVID-19 cancer patients admitted to hospital in a multicenter international registry (HOPE COVID-19).
Introduction: Patients with pre-existing respiratory diseases in the setting of COVID-19 may have a greater risk of severe complications and even death.
Methods: A retrospective, multicenter, cohort study with 5847 COVID-19 patients admitted to hospitals. Patients were separated in two groups, with/without previous lung disease.
Background: A systematic analysis of concomitant arterial hypertension in COVID-19 patients and the impact of angiotensin-converting-enzyme inhibitors (ACEI) or angiotensin receptor blockers (ARBs) have not been studied in a large multicentre cohort yet. We conducted a subanalysis from the international HOPE Registry (https://hopeprojectmd.com, NCT04334291) comparing COVID-19 in presence and absence of arterial hypertension.
View Article and Find Full Text PDFBackground: Smoking has been associated with poorer outcomes in relation to COVID-19. Smokers have higher risk of mortality and have a more severe clinical course. There is paucity of data available on this issue, and a definitive link between smoking and COVID-19 prognosis has yet to be established.
View Article and Find Full Text PDFBackground: Previous works seem to agree in the higher mortality of cancer patients with COVID-19. Identifying potential prognostic factors upon admission could help identify patients with a poor prognosis.
Methods: We aimed to explore the characteristics and evolution of COVID-19 cancer patients admitted to hospital in a multicenter international registry (HOPE COVID-19).
Gender-related differences in COVID-19 clinical presentation, disease progression, and mortality have not been adequately explored. We analyzed the clinical profile, presentation, treatments, and outcomes of patients according to gender in the HOPE-COVID-19 International Registry. Among 2,798 enrolled patients, 1,111 were women (39.
View Article and Find Full Text PDFObjectives: No standard therapy, including anticoagulation regimens, is currently recommended for coronavirus disease 2019. Aim of this study was to evaluate the efficacy of anticoagulation in coronavirus disease 2019 hospitalized patients and its impact on survival.
Design: Multicenter international prospective registry (Health Outcome Predictive Evaluation for Corona Virus Disease 2019).
Background: The use of Renin-Angiotensin system inhibitors (RASi) in patients with coronavirus disease 2019 (COVID-19) has been questioned because both share a target receptor site.
Methods: HOPE-COVID-19 (NCT04334291) is an international investigator-initiated registry. Patients are eligible when discharged after an in-hospital stay with COVID-19, dead or alive.
Background: Obesity has been described as a protective factor in cardiovascular and other diseases being expressed as 'obesity paradox'. However, the impact of obesity on clinical outcomes including mortality in COVID-19 has been poorly systematically investigated until now. We aimed to compare clinical outcomes among COVID-19 patients divided into three groups according to the body mass index (BMI).
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