Power of narrative: a case study about documenting private insightful experiences while dealing with pain and associated disability.

Objective: People adjusting to living with a chronic disability, such as chronic pain, seek support and resources from societal systems, including health systems, to help them cope with this reality. This case study describes the use of a digital health platform designed to help in that quest.

Method: MyHealthMyRecord (MHMR), is being developed to record, register and curate personal private experiences of a chronic condition.

Assessing subjective workload for live captioners.

Live captioning is a challenging task that requires intense concentration to convert audio to text in real-time. Despite the importance of live captioning for accessibility, little is known about the subjective workload of captioners in this context. This study aimed to measure the subjective workload of live captioners using the NASA-TLX and to explore the factors that contribute to their mental workload.

Does bouncy equal happy? Comparing user's interpretations of emotions conveyed by one designed moving object based on the soma-semiotic framework.

When designing objects, designers attempt to communicate the purpose and meaning of that object to users using various factors such as visual appearance (aesthetic), practical interaction elements (product semantics) and meanings beyond the practical product interaction (semiotics). This study sought to confirm the previous deductively-developed soma-semiotic framework, whose purpose was to understand and ultimately predict the emotional impact of different design elements on users, using one specifically designed object, Fruit Bowl (FB). The purpose of the study reported in this paper was to compare the theoretically derived emotional responses to FB from the soma-semiotic framework with empirically derived data from users in order to improve the framework.

Psoralen Derivatives with Enhanced Potency.

Psoralen is a furocoumarin natural product that intercalates within DNA and forms covalent adducts when activated by ultraviolet radiation. It is well known that this property contributes to psoralen's clinical efficacy in several disease contexts, which include vitiligo, psoriasis, graft-versus-host disease and cutaneous T-cell lymphoma. Given the therapeutic relevance of psoralen and its derivatives, we attempted to synthesize psoralens with even greater potency.

Ergonomics in apiculture: A case study based on inspecting movable frame hives for healthy bee activities.

The agricultural sector suffers from high risk of injury and damage to human health. There is considerable research not only identifying these risks but also finding ways to mitigate them. Beekeeping or apiculture, recognised as part of this sector, has many risk factors such as heavy lifting, high degree of manual materials handling, twisting, and awkward positioning common to all agriculture areas.

Impacts on quality: Enjoyment factors in blind and low vision audience entertainment ratings: A qualitative study.

Audio description (AD) is one of the main methods that people who are blind or low vision (B/LV) use to access film, television, and theatre content. AD is a second audio track inserted into the space(s) where speech is absent, which tends to be only a few seconds. Contained in that second track is an audio description of the important visual information contained within a specific scene.

The Double-Aspect of Life.

Life is based on two aspects: matter and a non-material, electrical component. In a dynamic system of reciprocal causality, matter and the so-called bioelectricity interact with one another, forming a functional unity. The aim of this essay is to summarize evidence for bioelectricity, for the sensitivity of biosystems to external physical factors and for the interactions of internal bioelectricity with internal biochemical structures.

Endogenous physical regulation of population density in the freshwater protozoan Paramecium caudatum.

Studies confirm physical long-range cell-cell communication, most evidently based on electromagnetic fields. Effects concern induction or inhibition of cell growth. Their natural function is unclear.

Physical Non-Contact Communication between Microscopic Aquatic Species: Novel Experimental Evidences for an Interspecies Information Exchange.

Previous experiments on physical non-contact communication within same species gave rise to test for this type of communication also across the species border, which was the aim of the present study. It was found that autotrophic unicellular organisms (Euglena viridis), separated by cuvettes, affected the proliferation rate of heterotrophic unicellular organisms (Paramecium caudatum). Further, the heterotrophic unicellular organism affected also the proliferation rate of a multicellular heterotrophic organism (Rotatoria sp.

FAS Death Receptor: A Breast Cancer Subtype-Specific Radiation Response Biomarker and Potential Therapeutic Target.

Although a standardized approach to radiotherapy has been used to treat breast cancer, regardless of subtype (e.g., luminal, basal), recent clinical data suggest that radiation response may vary significantly among subtypes.

PET with 62Cu-ATSM and 62Cu-PTSM is a useful imaging tool for hypoxia and perfusion in pulmonary lesions.

Objective: Hypoxia is a characteristic of many tumors and portends a worse prognosis in lung, cervical, prostate, and rectal cancers. Unlike the others, lung cancers present a unique challenge in measuring hypoxia, with invasive biopsies and higher rates of complications. Noninvasive imaging studies detecting hypoxia using isotopes of copper-diacetyl-bis(N4-methylthiosemicarbazone) ((62)Cu-ATSM) have predicted prognosis and treatment outcomes in some small feasibility trials.

Non-chemical and non-contact cell-to-cell communication: a short review.

Cell-to-cell communication is the basis of coordinated cellular activity and thus fundamental for the functioning of biological systems. In a recently published research article by Chaban et al. (Am.

Modulation of circulating angiogenic factors and tumor biology by aerobic training in breast cancer patients receiving neoadjuvant chemotherapy.

Aerobic exercise training (AET) is an effective adjunct therapy to attenuate the adverse side-effects of adjuvant chemotherapy in women with early breast cancer. Whether AET interacts with the antitumor efficacy of chemotherapy has received scant attention. We carried out a pilot study to explore the effects of AET in combination with neoadjuvant doxorubicin-cyclophosphamide (AC+AET), relative to AC alone, on: (i) host physiology [exercise capacity (VO2 peak), brachial artery flow-mediated dilation (BA-FMD)], (ii) host-related circulating factors [circulating endothelial progenitor cells (CEP) cytokines and angiogenic factors (CAF)], and (iii) tumor phenotype [tumor blood flow ((15)O-water PET), tissue markers (hypoxia and proliferation), and gene expression] in 20 women with operable breast cancer.

Portraits of people with dementia: three case studies of creating portraits.

Communication difficulties associated with late-stage dementia can make it difficult for care staff in residential environments to get to know people with dementia. This lack of knowledge can have a negative effect on the social environment of residential facilities, which can have a detrimental effect on the health and well-being of the residents and the job satisfaction of the staff. In this article, we discuss the creation of portraits of people with dementia to aid care staff in understanding the individual.

Feeling voices.

Two experiments investigated deaf individuals' ability to discriminate between same-sex talkers based on vibrotactile stimulation alone. Nineteen participants made same/different judgments on pairs of utterances presented to the lower back through voice coils embedded in a conforming chair. Discrimination of stimuli matched for F0, duration, and perceived magnitude was successful for pairs of spoken sentences in Experiment 1 (median percent correct = 83%) and pairs of vowel utterances in Experiment 2 (median percent correct = 75%).

Sickle erythrocytes target cytotoxics to hypoxic tumor microvessels and potentiate a tumoricidal response.

Resistance of hypoxic solid tumor niches to chemotherapy and radiotherapy remains a major scientific challenge that calls for conceptually new approaches. Here we exploit a hitherto unrecognized ability of sickled erythrocytes (SSRBCs) but not normal RBCs (NLRBCs) to selectively target hypoxic tumor vascular microenviroment and induce diffuse vaso-occlusion. Within minutes after injection SSRBCs, but not NLRBCs, home and adhere to hypoxic 4T1 tumor vasculature with hemoglobin saturation levels at or below 10% that are distributed over 70% of the tumor space.

Vibrotactile discrimination of musical timbre.

Five experiments investigated the ability to discriminate between musical timbres based on vibrotactile stimulation alone. Participants made same/different judgments on pairs of complex waveforms presented sequentially to the back through voice coils embedded in a conforming chair. Discrimination between cello, piano, and trombone tones matched for F0, duration, and magnitude was above chance with white noise masking the sound output of the voice coils (Experiment 1), with additional masking to control for bone-conducted sound (Experiment 2), and among a group of deaf individuals (Experiment 4a).

Exercise modulation of the host-tumor interaction in an orthotopic model of murine prostate cancer.

The purpose of this study is to investigate the effects of exercise on cancer progression, metastasis, and underlying mechanisms in an orthotopic model of murine prostate cancer. C57BL/6 male mice (6-8 wk of age) were orthotopically injected with transgenic adenocarcinoma of mouse prostate C-1 cells (5 × 10(5)) and randomly assigned to exercise (n = 28) or a non-intervention control (n = 31) groups. The exercise group was given voluntary access to a wheel 24 h/day for the duration of the study.

Storytelling as a model of conversation for people with dementia and caregivers.

Storytelling is an important method of communication at all stages of life. Sharing narratives about lived events and experiences provides topics of conversation and opportunities for connecting with other people. In this article, we apply a conventional model of storytelling to the verbal reminiscences of older people with a dementia diagnosis.

Cytotoxic effects of Mn(III) N-alkylpyridylporphyrins in the presence of cellular reductant, ascorbate.

Due to the ability to easily accept and donate electrons Mn(III)N-alkylpyridylporphyrins (MnPs) can dismute O(2)(·-), reduce peroxynitrite, but also generate reactive species and behave as pro-oxidants if conditions favour such action. Herein two ortho isomers, MnTE-2-PyP(5+), MnTnHex-2-PyP(5+), and a meta isomer MnTnHex-3-PyP(5+), which differ greatly with regard to their metal-centered reduction potential, E(1/2) (Mn(III)P/Mn(II)P) and lipophilicity, were explored. Employing Mn(III)P/Mn(II)P redox system for coupling with ascorbate, these MnPs catalyze ascorbate oxidation and thus peroxide production.

Exercise behavior, functional capacity, and survival in adults with malignant recurrent glioma.

Purpose: Identifying strong markers of prognosis are critical to optimize treatment and survival outcomes in patients with malignant recurrent glioma. We investigated the prognostic significance of exercise behavior and functional capacity in this population.

Patients And Methods: Using a prospective design, 243 patients with WHO grades 3 to 4 recurrent malignant glioma and Karnofsky performance status (KPS) ≥ 70 completed a self-administered questionnaire that assessed exercise behavior and performed a 6-minute walk test (6MWT) to assess functional capacity.

Comparison of genomics and functional imaging from canine sarcomas treated with thermoradiotherapy predicts therapeutic response and identifies combination therapeutics.

Purpose: While hyperthermia is an effective adjuvant treatment to radiotherapy, we do not completely understand the nature of the response heterogeneity.

Experimental Design: We performed gene expression analysis of 22 spontaneous canine sarcomas before and after the first hyperthermia treatment administered as an adjuvant to radiotherapy. In parallel, diffusion-weighted MRI (DWI) was done prior to the treatment course and at the end of therapy.

Bioavailability of metalloporphyrin-based SOD mimics is greatly influenced by a single charge residing on a Mn site.

In the cell Mn porphyrins (MnPs) likely couple with cellular reductants which results in a drop of total charge from 5+ to 4+ and dramatically increases their lipophilicity by up to three orders of magnitude depending upon the length of alkylpyridyl chains and type of isomer. The effects result from the interplay of solvation, lipophilicit and stericity. Impact of ascorbate on accumulation of MnPs was measured in E.

Cellular communication through light.

Information transfer is a fundamental of life. A few studies have reported that cells use photons (from an endogenous source) as information carriers. This study finds that cells can have an influence on other cells even when separated with a glass barrier, thereby disabling molecule diffusion through the cell-containing medium.

Designing the Model Human Cochlea: An Ambient Crossmodal Audio-Tactile Display.

We present a model human cochlea (MHC), a sensory substitution technique and system that translates auditory information into vibrotactile stimuli using an ambient, tactile display. The model is used in the current study to translate music into discrete vibration signals displayed along the back of the body using a chair form factor. Voice coils facilitate the direct translation of auditory information onto the multiple discrete vibrotactile channels, which increases the potential to identify sections of the music that would otherwise be masked by the combined signal.