Families' situation of caring for a child with a chronic condition: a mixed methods study.

Objective: To analyze the meanings attributed by family members to the situation of caring for a child with a chronic condition (CCC), in the light of the Family Management Style Framework (FMSF).

Method: A mixed-methods, parallel-convergent study, guided by the FMSF theoretical framework, using the conceptual component "Definition of the Situation". Fifty-three CCC families took part.

Diagnosis and Treatment of Advanced ALK Rearrangement-Positive Non-Small-Cell Lung Cancer in Portugal: Results of a National Questionnaire.

Background: Rearrangements in the anaplastic lymphoma kinase (ALK) gene define a molecular subgroup of non-small-cell lung carcinoma (NSCLC) that should be treated with ALK-targeting tyrosine kinase inhibitors (TKIs).

Objective: This study aimed to portray the Portuguese reality about the diagnosis and treatment of stage IV ALK-positive NSCLC.

Methods: Institutions that treat lung cancer in Portugal were invited to participate in an anonymous electronic questionnaire.

Liquid biopsy in the management of advanced lung cancer: Implementation and practical aspects.

Non-small-cell lung cancer (NSCLC) is a major cause of cancer-related death worldwide. In recent years, the discovery of actionable molecular alterations has changed the treatment paradigm of the disease. Tissue biopsies have been the gold standard for the identification of targetable alterations but present several limitations, calling for alternatives to detect driver and acquired resistance alterations.

Evaluation of the efficiency of a Venturi scrubber in particulate matter collection smaller than 2.5 µm emitted by biomass burning.

Energy demand has increased worldwide, and biomass burning is one of the solutions most used by industries, especially in countries that have a great potential in agriculture, such as Brazil. However, these energy sources generate pollutants, consisting of particulate matter (PM) with a complex chemical composition, such as sugarcane bagasse (SB) burning. Controlling these emissions is necessary; therefore, the aim was to evaluate PM collection using a rectangular Venturi scrubber (RVS), and its effects on the composition of the PM emitted.

Detection and quantification of T790M mutation in liquid biopsies by droplet digital PCR.

Background: Liquid biopsy allows the identification of targetable cancer mutations in a minimally invasive manner. In patients with advanced non-small cell lung cancer (NSCLC), droplet digital PCR (ddPCR) is increasingly used to genotype the epidermal growth factor receptor () gene in circulating cell-free DNA (cfDNA). However, the sensitivity of this method is still under debate.

Detection of rare and novel EGFR mutations in NSCLC patients: Implications for treatment-decision.

Objectives: Mutations in the gene that encodes epidermal growth factor receptor (EGFR) are biomarkers that predict how non-small cell lung cancer (NSCLC) patients respond to EGFR-targeted therapies collectively known as tyrosine kinase inhibitors (TKIs). Thus, EGFR genotyping provides crucial information for treatment decision. Both Sanger sequencing and real-time PCR methodologies are used for EGFR genotyping.

Real-world data from the Portuguese Nivolumab Expanded Access Program (EAP) in previously treated Non Small Cell Lung Cancer (NSCLC).

Objective: The main aim of the study was to evaluate the efficacy and safety profile of Nivolumab, an immune-checkpoint-inhibitor antibody, in advanced, previously treated, Non-Small Cell Lung Cancer (NSCLC) patients, in a real world setting.

Methods: We performed a retrospective, multicentre data analysis of patients who were included in the Portuguese Nivolumab Expanded Access Program (EAP). Eligibility criteria included histologically or citologically confirmed NSCLC, stage IIIB and IV, evaluable disease, sufficient organ function and at least one prior line of chemotherapy.

APPLICATION OF DROPLET DETECTORS TO ALPHA RADIATION DETECTION.

Superheated droplet detectors (SDDs) are traditionally employed in the detection of neutrons. In this work the focus is on the detection of alpha particles using C2ClF5 as the target liquid. The alpha-droplet interaction is examined via computational studies, and a geometric model developed to describe the expected detector response.

Molecular survey of Cytomegalovirus shedding profile in commercial pig herds in Brazil.

Introduction: Porcine cytomegalovirus (PCMV) causes rhinitis in both young and older pigs. The present study describes the detection and characterization of shedding profiles of PCMV in nine farrow-to-finish Brazilian swine herds.

Methodology: Tonsil swabs from sows, nursery and grow-finish pigs of nine farrow-to-finish commercial herds (n = 756) were evaluated for the presence of PCMV by PCR.

Pheno- and genotypic characterization of Pasteurella multocida isolated from cats, dogs and rabbits from Brazil.

Pasteurella multocida is the causative agent of many diseases of economic importance in veterinary medicine and is characterized by high zoonotic potential. Pet animals can be infected and play a major role as carriers. This study aimed to characterize the genetic diversity of P.

Antimicrobial resistance and virulence gene profiles in P. multocida strains isolated from cats.

Cats are often described as carriers of Pasteurella multocida in their oral microbiota. This agent is thought to cause pneumonia, conjunctivitis, rhinitis, gingivostomatitis, abscess and osteonecrosis in cats. Human infection with P.

Draft Genome Sequence of Bordetella avium Nh1210, an Outbreak Strain of Lockjaw Syndrome.

Bordetella avium is a highly contagious bacterium that infects the upper respiratory tract of birds. B. avium Nh1210 is an outbreak strain of lockjaw syndrome in juvenile cockatiel chicks (Nymphicus hollandicus).

Accuracy of the vertical tube shift method in identifying the relationship between the third molars and the mandibular canal.

Objectives: The objective of this study is to assess the accuracy of the vertical tube shift method in identifying the relationship between the mandibular canal (MC) and third molars.

Materials And Methods: Two examiners assessed image sets of 173 lower third molar roots (55 patients) using forced consensus. The image sets comprised two methods: PERI, two periapical radiographs (taken at 0° and -30°), and PAN, a panoramic radiograph (vertical angulation of -8°) and a periapical radiograph taken at a vertical angulation of -30°.

Final analysis and results of the Phase II SIMPLE dark matter search.

We report the final results of the Phase II SIMPLE measurements, comprising two run stages of 15 superheated droplet detectors each, with the second stage including an improved neutron shielding. The analyses include a refined signal analysis, and revised nucleation efficiency based on a reanalysis of previously reported monochromatic neutron irradiations. The combined results yield a contour minimum of σp=5.

Colistin resistance in Escherichia coli and Salmonella enterica strains isolated from swine in Brazil.

Reports about acquired resistance to colistin in different bacteria species are increasing, including E. coli of animal origin, but reports of resistance in wild S. enterica of different serotypes from swine are not found in the literature.

Virulence genes and antimicrobial resistance profiles of Pasteurella multocida strains isolated from rabbits in Brazil.

Pasteurella multocida is responsible for a wide range of diseases in domestic animals. In rabbits, the agent is related to nasal discharge, pneumonia, otitis media, pyometra, orchitis, abscess, and septicemia. One hundred and forty rabbits with respiratory diseases from four rabbitries in São Paulo State, Brazil were evaluated for the detection of P.

Virulence and molecular aspects of Bordetella avium isolated from cockatiel chicks (Nymphicus hollandicus) in Brazil.

Bordetella avium is an opportunistic pathogen that presents tropism for ciliated epithelia, leading to upper respiratory tract disease in turkeys. This agent has also been associated with Lockjaw Syndrome in psittacine birds, but literatures describing the importance of this agent in such species are rare. The purpose of the present study was to report the first outbreak of B.

First results of the Phase II SIMPLE dark matter search.

We report results of a 14.1   kg d measurement with 15 superheated droplet detectors of total active mass 0.208 kg, comprising the first stage of a 30 kg d Phase II experiment.

Organising pneumonia - the experience of an outpatient clinic of a central hospital.

Aim: to characterise outpatients of a Portuguese central hospital diagnosed with organising pneumonia (OP) and compare results with current literature.

Methods: medical processes with diagnosis of OP were retrospectively studied as to demographics, aetiology, clinical and radiological features, average time until and date of diagnosis, laboratory and histological changes, treatment and relapse. Results - thirteen patients with a mean follow -up of 171.

To circ or not to circ: clinical and pharmacoeconomic outcomes of a prospective trial of topical steroid versus primary circumcision.

Purpose: To compare the efficacy and costs of circumcision versus topical treatment using a prospective pharmacoeconomic protocol.

Materials And Methods: We treated 59 patients (3-10 years of age) randomized into two groups: 29 underwent an 8-week course of topical treatment with 0.2% betamethasone-hyaluronidase cream twice a day; and 30 underwent circumcision.

Obstructive sleep apnoea syndrome as a cause of road traffic accidents.

Unlabelled: Several studies have demonstrated that obstructive sleep apnoea syndrome (OSAS) patients have a higher rate of road traffic accidents. Our study aimed to analyse any differences in OSAS patients between those who reported having had road traffic accidents and/or near misses and those who did not.

Methods: We studied 163 patients with OSAS (apnoea- hypopnoea index (AHI)>10/h) diagnosed using nocturnal polysomnography (NPSG), all drivers, 18.

Four years' follow up at a smoking cessation clinic.

Unlabelled: Smoking is an important cause of pulmonary pathology and this addiction can be regarded as a chronic, recurrent disease. The benefits of smoking cessation are unquestionable and all physicians should become more active and assertive in recommending it.

Aim: To characterise the population seeking medical support for smoking cessation and understand why some successfully stop smoking and others do not.

Intravascular pulmonary lymphoma with good response to treatment. A case report.

Intravascular lymphoma is a very rare form of large B cell non-Hodgkin's lymphoma, characterised by the presence of lymphoma cells in the lumina of small vessels only, particularly in the capillaries. We report a 54 year-old female non-smoker, admitted to hospital for further examination of a four month long clinical condition involving high fever, night sweats, unqualified weight loss and progressive dyspnea. Patient's temperature was 38.

[Surgery of pulmonary metastasis].

Unlabelled: Between April 1993 and December 2007, 92 patients underwent the complete resection of pulmonary metastases, 47 mens (51.1%) and 45 womens (49.9%).