Publications by authors named "Felix Racine-Brassard"
Article Synopsis
- - DNA replication stress (RS) is a condition that can cause replication forks to slow down or stop, leading to genome instability and cell death, particularly in cancer cells where it can be exacerbated by chemotherapy.
- - Checkpoint kinases ATR and CHK1 usually protect against the harmful effects of RS by stabilizing replication forks and enforcing cell cycle arrest when issues arise.
- - Research shows that while specific inhibitors of ATR and CHK1 can enhance replication stress and promote cancer cell death, they do not significantly increase mutations in human cancer cells in vitro, suggesting minimal mutagenic effects when used alone.
Illudin S (ILS) is a fungal sesquiterpene secondary metabolite with potent genotoxic and cytotoxic properties. Early genetic studies and more recent genome-wide CRISPR screens showed that Illudin-induced lesions are preferentially repaired by transcription-coupled nucleotide excision repair (TC-NER) with some contribution from post-replication repair pathways. In line with these results, Irofulven, a semi-synthetic ILS analog was recently shown to be particularly effective on cell lines and patient-derived xenografts with impaired NER (e.
View Article and Find Full Text PDF