Publications by authors named "Felix Oghenemaro Enwa"
Glutaminyl-peptide cyclotransferase-like protein (QPCTL) is a newly discovered enzyme that has sparked interest owing to its possible role in cancer genesis and progression. Initially discovered as a post-translational modification regulator of protein maturation, QPCTL has emerged as a key participant in cancer biology. Recent research has linked QPCTL to numerous essential cancer-related processes, including cell proliferation, migration, invasion, and apoptosis.
View Article and Find Full Text PDFThe development of cancer immunology heavily relies on the interaction between long non-coding RNAs (lncRNAs) and molecular chaperones. By participating in gene regulation, lncRNAs interact with molecular chaperones, which play a critical role in protein folding and stress responses, to influence oncogenic pathways. This interaction has an impact on both the immune cells within the tumor microenvironment and the tumor cells themselves.
View Article and Find Full Text PDFArticle Synopsis
- Chemotherapy has significantly increased the survival rates of cancer patients, but it may also cause harmful effects on the heart, leading to potential heart failure.
- The main cause of chemotherapy-induced cardiotoxicity (CIC) is believed to be the production of free radicals, which creates oxidative stress.
- The review highlights the Sirtuin-1 (Sirt1)/Nuclear factor E2-associated factor 2 (Nrf2) signaling pathway as a promising method to combat CIC by reducing oxidative stress, inflammation, and cell death.
Article Synopsis
- - The study investigates malaria prevalence in individuals with HIV in Warri, Nigeria, revealing a high infection rate of 38% among HIV-positive participants compared to 39% among HIV-negative individuals, with no significant difference found.
- - A total of 600 participants were analyzed using WHO screening methods and Geimsa staining to evaluate malaria parasite density, revealing that HIV-positive individuals had a significantly higher mean parasite density (2384 ± 747) compared to HIV-negative individuals (1883 ± 645).
- - The research highlights a concerning level of malaria infection among people living with HIV, underscoring the need for targeted healthcare interventions in the affected community.