Publications by authors named "Felix I Simonovsky"
Biomaterials
December 2021
Article Synopsis
- There is a significant demand for improved vascular grafts, especially small diameter non-biologic ones, and existing medium diameter grafts show subpar performance.
- Researchers developed biostable polyurethane scaffolds with 40 μm pores that match the mechanical properties of natural blood vessels, aiming to enhance integration and healing while minimizing foreign body reactions.
- Testing in mice for 3 weeks revealed that these 40 μm porous scaffolds promoted the best angiogenesis and cellular activity, suggesting their potential for use in vascular grafts, tissue engineering, and other medical applications.
Adv Healthc Mater
May 2022
Article Synopsis
- New linear segmented poly(peptide-urethane-urea) (PPUU) block copolymers are created, containing soft, hard, and oligopeptide segments for enhanced properties.
- The soft segment is poly(caprolactone diol) (PCL), while the hard segment consists of lysine diisocyanate and hydrazine; the oligopeptide segment is made up of amino acids proline, hydroxyproline, and glycine.
- Surface composition analysis using angle dependent X-ray photoelectron spectroscopy and time-of-flight secondary ion mass spectrometry reveals that the hydrophobic PCL segment is predominant on the surfaces of all four polymers,
ACS Biomater Sci Eng
September 2016
Article Synopsis
- Researchers developed a new class of polyurethanes mixed with PLGA that degrade faster than traditional options, addressing the challenge of sustained drug release from electrospun fibers.
- The study involved synthesizing polymers with different ratios and characteristics, characterizing them with advanced techniques, and testing drug compatibility and release.
- Findings indicate that adjusting the composition of the polyurethane can improve drug release rates while ensuring the materials biodegrade effectively and are safe for cells.
Acta Biomater
September 2011
Article Synopsis
- * There is limited research on melt electrospinning due to technical challenges like high-temperature requirements and suitable polymer development.
- * This study introduces a biodegradable polyurethane formulation that can be effectively electrospun, resulting in scaffolds with desirable mechanical properties and non-toxic characteristics.
Biomaterials
January 2011
Article Synopsis
- This study focuses on developing synthetic polymer scaffolds for urethra repairs by discovering proteins that help cells attach effectively.*
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- Researchers tested two types of scaffolds and found type I collagen, type IV collagen, and vitronectin at the interface of urethral tissue, confirming their relevance for the study.*
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- The results indicated that vitronectin showed the best retention on the scaffolds, making it a preferred protein for optimizing cell attachment in urethroplastic applications.*
J Biomater Sci Polym Ed
January 2006
Article Synopsis
- * The polyurethanes were synthesized through a multi-step process involving a diisocyanate pre-polymer and various chain extenders, with different types of side-chains incorporated into the polymer structure.
- * Results showed that while some changes in fibrinogen and albumin adsorption occurred with different side-chains, the polyurethanes featuring oxyethylene-C16-carboxyalkyl side-chains had the best performance, showing lower fibrinogen and higher albumin adsorption compared to other tested polymers.
J Biomed Mater Res A
September 2005
Article Synopsis
- - The study tested ten types of specially made polyurethanes (PUs) to see how their surface properties influence platelet adhesion, focusing on factors like hydrophilicity and the adsorption of proteins like fibrinogen (Fg) and von Willebrand's factor (vWf).
- - It was found that PUs that didn't absorb Fg showed very low platelet adhesion, indicating that Fg is crucial for this process; however, some hydrophobic PUs with high Fg absorption surprisingly displayed lower adhesion.
- - The research also involved monoclonal antibodies that bind to specific parts of Fg, revealing that the binding to one specific site on Fg correlated strongly with platelet adhesion, while other sites could partially block adhesion,
J Biomater Sci Polym Ed
January 2006
Article Synopsis
- - A variety of segmented poly(ether urethane)s and poly(ether urethane urea)s were created using chain-extension techniques on pre-polymers made from poly(tetramethylene oxide) and 4,4'-diphenylmethane diisocyanate.
- - Different chain extenders, including glycerol and various diols and diamines, were added to incorporate functional groups into the polymer structure, allowing for complex branching and functionalization.
- - The synthesized polymers were analyzed using techniques such as 1H-NMR, FT-IR spectroscopy, and GPC, and their structures were confirmed by comparing them to known model compounds.
