Publications by authors named "Felix Boon Bin Yap"

H1-antihistamines are recognized to be effective for conditions such as allergic rhinitis and chronic spontaneous urticaria. However, management of such conditions in the real-world primary care setting may be challenging due to diverse patient-specific considerations, the wide range of antihistamines available, choice of other treatment modalities, and the complexity of interpreting specialist treatment algorithms. Despite regular updates to international guidelines, regional/national surveys of healthcare professionals show a clear gap between guidelines and real-world practice, particularly at the primary care level.

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  • The study assessed the efficacy and safety of fixed-dose 10 mg daily isotretinoin for acne treatment, with a total of 150 patients involved.
  • Patients showed total clearance from acne after an average of 24 weeks, with better outcomes observed in those with more severe cases.
  • Common side effects included lip dryness, while significant liver or lipid issues were rare, confirming that this low-dose treatment is generally safe with a low relapse rate.
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  • Acne is seen as a cosmetic issue in Malaysia, but its psychological effects on individuals are not well-studied.
  • The study examined the quality of life impact of acne on 200 patients using the Cardiff Acne Disability Index (CADI) and found that most experienced mild impairment, particularly in emotional well-being.
  • Findings suggest that lower family income and certain demographics (females, indigenous groups, and those with higher education) are linked to greater emotional distress from acne, highlighting the need for better management and resources.
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Sporotrichosis is a subacute or chronic fungal infection caused by the ubiquitous fungus Sporothrix schenckii. Disseminated cutaneous sporotrichosis is an uncommon entity and is usually present in the immunosuppressed. Here, a case of disseminated cutaneous sporotrichosis in an immunocompetent patient is reported.

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  • A study analyzed 31 cases of cutaneous larva migrans (CLM) at Hospital Kuala Lumpur from 2006 to 2010, finding that most patients were male with an average age of 32.2 years.
  • Pruritus was common in 83.9% of patients, and all exhibited serpiginous skin lesions, predominantly located on the buttocks and lower limbs, averaging 4.4 lesions per person and a 3.1-week delay before seeking treatment.
  • Only 45.2% of these cases were correctly diagnosed by primary care doctors, indicating a significant need for improved education regarding CLM to enhance diagnostic accuracy among healthcare providers.
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A case of syringocystadenoma papilliferum with multiple papulonodules in a linear fashion located in an unusual location of the right lower abdomen is presented. The presence of a large tumor at the inferior pole raised the suspicion of malignant transformation and the presence of discharge from the lesions raised the possibility of necrosis. However, histopathological examination showed the classical features of syringocystadenoma papilliferum without malignant transformation or tumor necrosis.

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  • A study was conducted between December 2007 and June 2009 at Sarawak General Hospital to analyze 138 native Sarawakians diagnosed with psoriasis.
  • The average age of participants was 45.2 years, with women representing 50.7% of the group.
  • Most patients (94.2%) had chronic stable plaque psoriasis, and a majority reported minimal impact on their quality of life, despite some having associated nail (60.9%) and joint disease (22.5%).
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  • Penicilliosis is a systemic fungal infection caused by Penicillium marneffei, primarily found in Southeast Asia and rarely among Africans.
  • A case was reported involving an African man studying in Malaysia, who showed symptoms like cough, fever, and skin lesions, indicating a more serious health issue.
  • The diagnosis was confirmed through lab tests, highlighting the importance of recognizing this infection in travelers to Southeast Asia and monitoring for HIV in patients with similar symptoms.
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Background: Basal cell carcinoma (BCC) is the most common skin cancer among Orientals. Data on this malignancy is lacking in Malaysia, prompting a retrospective study to determine the clinical characteristics in the skin clinic, Sarawak General Hospital between 2000 and 2008.

Methods: Demographic data and clinical features of 64 histopathologically proven BCC from 43 patients were retrieved.

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A 30-year-old man presented to the genitourinary medicine clinic with the sudden appearance of an asymptomatic, 2 mm wide, flesh-colored, firm, and cord-like lesion encircling the coronal sulcus circumferentially following vigorous sexual intercourse with his wife. An initial diagnosis of sexually transmitted disease-associated penile swelling was entertained. He was given antibiotics for this condition.

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A retrospective study was conducted to determine the clinical characteristics and treatment outcomes of 11 new patients with a histological diagnosis of chromoblastomycosis at Sarawak General Hospital, Malaysia, between 1996 and 2008. The majority (81.8%) were males, and the median age at presentation was 40 years.

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  • - A 43-year-old woman with type 2 diabetes and asthma developed a varicella zoster infection, experiencing symptoms like shortness of breath and neck fullness.
  • - A CT scan revealed a mediastinal abscess and a thrombus in the superior vena cava, with cultures from her blood and neck swab identifying group A beta hemolytic Streptococcus.
  • - She was treated successfully with a mix of broad-spectrum antibiotics, antivirals, and surgery to drain the abscess, highlighting the uncommon complications from this infection in adults.
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A 36-year-old Malaysian woman with erosive arthritis presented with multiple asymptomatic skin colored papulonodules on the hands, elbows, knees, ears, and feet; many macules, papules, and plaques were photodistributed. Progressive, erosive arthritis began about 18 months after the onset of skin involvement. Initially the patient was diagnosed to have dermatomyositis due to her skin findings, but later proved to have multicentric reticulohistiocytosis based on the typical histopathological features of histiocytic multinucleated giant cells with eosinophilic ground glass cytoplasm on skin biopsy.

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