Publications by authors named "Felix Angel Jalon"
J Biol Inorg Chem
September 2023
Article Synopsis
- Aromatase inhibitors (AIs) like Letrozole are gaining attention for treating hormone-dependent cancers, but they can cause side effects like hot flashes and fibromyalgia while posing risks such as endometrial cancer.
- New AI derivatives inspired by Letrozole have been developed, particularly one with a benzimidazole ring (compound 6), which shows better aromatase inhibitory activity and reduces cancer cell growth compared to established AIs.
- Compound 6 enhances binding to the aromatase enzyme due to its ferrocene structure, leading to improved interaction and increased effectiveness in inhibiting cancer cell proliferation.
