Ulnohumeral arthroplasty: results in primary degenerative arthritis of the elbow.

Our results with the ulnohumeral arthroplasty are presented. Seventeen patients were evaluated at an average followup greater than 36 months (range, 24-50 months). The average age of the patients was 52 years (range, 40-74 years).

Insulin growth factor-1 decreases muscle atrophy following denervation.

Despite modern microsurgical techniques for nerve repair, functional outcome following proximal injury is often unsatisfactory because irreversible muscle atrophy may develop before reinnervation occurs. Because insulin growth factor-1 (IGF-1) has been shown to improve muscle regeneration after injury, and may have a role in muscle preservation following denervation, the purpose of this investigation was to evaluate the histological, immunohistochemical, and electrophysiological differences between normal, denervated, and IGF-1-injected denervated muscle over an 8-week period. Denervated mice gastrocnemius muscles demonstrated a decrease in muscle weight, a decrease in myofiber diameter, an absence of muscle regeneration, an early increase in the number of neuromuscular junctions (NMJs), and a decrease in fast-twitch and maximum tetanic strength as compared to normal muscle up to 8 weeks following denervation.