Publications by authors named "Felipe de J Martinez-Ruiz"
Introduction: Serine proteases play a critical role during SARS-CoV-2 infection. Therefore, polymorphisms of transmembrane protease serine 2 () and serpine family E member 1 () could help to elucidate the contribution of variability to COVID-19 outcomes.
Methods: To evaluate the genetic variants of the genes previously associated with COVID-19 outcomes, we performed a cross-sectional study in which 1536 SARS-CoV-2-positive participants were enrolled.
Article Synopsis
- The study investigates the role of TLR7 and MyD88 gene polymorphisms in the severity of COVID-19 among unvaccinated individuals, analyzing a population of 618 patients.
- A significant association was found between specific genetic variations (rs3853839 for TLR7 and rs7744 for MyD88) and worse clinical outcomes, with specific genotypes linked to critical and severe cases.
- The findings suggest that these genetic markers could help predict COVID-19 severity and are associated with immune response factors like D-dimer and IFN-α concentrations.
Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) infection triggers inflammatory clinical stages that affect the outcome of patients with coronavirus disease 2019 (COVID-19). Disease severity may be associated with a metabolic imbalance related to amino acids, lipids, and energy-generating pathways. The aim of this study was to characterize the profile of amino acids and acylcarnitines in COVID-19 patients.
View Article and Find Full Text PDFSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the current coronavirus disease 2019 (COVID-19) pandemic, affecting more than 219 countries and causing the death of more than 5 million people worldwide. The genetic background represents a factor that predisposes the way the host responds to SARS-CoV-2 infection. In this sense, genetic variants of and could explain the observed interindividual variability to COVID-19 outcomes.
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