Carvacrol-Loaded Nanoemulsion Promotes Tocolytic and Anti-Dysmenorrhea Effects in Rodents.

Introduction: Carvacrol is a phenolic constituent of essential oils that has antinociceptive, anti-inflammatory, and antioxidant activities.

Method: This study aimed to evaluate the in vitro spasmolytic and in vivo anti-dysmenorrhea potential of a nanoemulsion-containing carvacrol (nanoCARV).

Results: In isolated rat uterus, nanoCARV reduced spontaneous contractions (pEC50 = 3.

H-BN nanosheets obtained by mechanochemical processes and its application in lamellar hybrid with graphene oxide.

Nowadays, hexagonal boron nitride nanosheets (h-BNNS) have shown promising results among 2D nanomaterials. A great effort has been made in recent years to obtain h-BNNS with a high-yield process to enable its large-scale application in industrial plants. In this work, we developed a mechanochemical method for obtaining h-BN nanosheets assisted by NaOH aqueous solution as process aid and aimed the ideal balance between yield, quality and process sustainability.