Efficacy and safety of surgical management for Rathke's cleft cysts in pediatric patients: a systematic review and meta-analysis.

Rathke's cleft cysts (RCCs) are benign, cystic lesions that account for less than 5% of cases in the pediatric population. While asymptomatic RCCs often require only conservative management, symptomatic cases may necessitate surgical intervention. Advances in surgical techniques have improved the safety of these procedures.

Gamma knife radiosurgery for orbital cavernous hemangioma: a systematic review and single-arm meta-analysis.

Purpose: Gamma knife radiosurgery (GKRS) for orbital cavernous hemangioma (OCH) has emerged as a promising method due to its significant clinical improvement and low incidence of complications. This study aimed to evaluate the safety and efficacy of GKRS for the treatment of OCH.

Methods: In accordance with the PRISMA framework, we searched PubMed, Cochrane Central, and Embase for studies reporting outcomes of GKRS for OCH.

History of pediatric neurosurgery in Latin America: the early years.

Purpose: Pediatric neurosurgical history in Latin America possesses rich and fascinating origins; the large number of neurosurgical societies that form the continent and the inspiring achievements of the pioneers in the field in every single Latin American country are described here. This unique text explores the aspects of this neurosurgical specialty since its beginnings by neurosurgeons trained outside Latin America, who brought the pediatric practice to their home countries, writing a new chapter in the neurosurgical history, constructing the foundations for the present pediatric practice and the few fellowships found in the continent.

Methods, Results And Conclusion: A formal search was performed in PubMed, Embase, and national libraries focused on the historical and biographical aspects of pioneers' pediatric neurosurgeons of Argentina, Brazil, Colombia, Venezuela, Peru, Chile, and Ecuador, with an important session that describes the fellowships' opportunities in pediatric neurosurgery found in the continent, dividing all the programs according to the countries that offer the subspecialty education.

How to become a pediatric neurosurgeon in Latin America: training opportunities, current status, and future challenges.

Purpose: To provide an analysis of pediatric neurosurgery educational opportunities in Latin America in order to characterize and evaluate the strengths, weaknesses, and limitations to assume a career in pediatric neurosurgery.

Methods: An online survey was distributed to pediatric neurosurgeons in Latin America to assess aspects of pediatric neurosurgical education, working conditions, and training opportunities. The survey was open to neurosurgeons that treat pediatric patients, whether or not they had completed fellowship training in pediatrics.

8-Substituted 1,3-dimethyltetrahydropyrazino[2,1-f]purinediones: Water-soluble adenosine receptor antagonists and monoamine oxidase B inhibitors.

Multitarget approaches, i.e., addressing two or more targets simultaneously with a therapeutic agent, are hypothesized to offer additive therapeutic benefit for the treatment of neurodegenerative diseases.

8-Benzyltetrahydropyrazino[2,1-f]purinediones: water-soluble tricyclic xanthine derivatives as multitarget drugs for neurodegenerative diseases.

8-Benzyl-substituted tetrahydropyrazino[2,1-f]purinediones were designed as tricyclic xanthine derivatives containing a basic nitrogen atom in the tetrahydropyrazine ring to improve water solubility. A library of 69 derivatives was prepared and evaluated in radioligand binding studies at adenosine receptor (AR) subtypes and for their ability to inhibit monoamine oxidases (MAO). Potent dual-target-directed A1 /A2A adenosine receptor antagonists were identified.