Publications by authors named "Felipe Le Divenah"
Clin Chim Acta
November 2023
Article Synopsis
- Circulating creatinine is a vital clinical biomarker that can be affected by the antidote N-acetylcysteine (NAC) in cases of acetaminophen (APAP) poisoning, specifically interfering with the creatininase-peroxidase testing methods.
- The study included tests on both spiked plasma and a review of patients treated with NAC, finding that the creatininase-peroxidase method was significantly impaired at therapeutic NAC levels, while the creatininase-amperometric methods showed no such interference.
- The results suggest that enzymo-amperometric assays are reliable for measuring creatinine levels in APAP overdose patients receiving NAC, minimizing the risk of inaccurately low
