Publications by authors named "Felipe H S Silva"
Members of the SOX (SRY-related HMG box) family of transcription factors are crucial for embryonic development and cell fate determination. This review investigates the role of SOX3 in cancer, as aberrations in SOX3 expression have been implicated in several cancers, including osteosarcoma, breast, esophageal, endometrial, ovarian, gastric, hepatocellular carcinomas, glioblastoma, and leukemia. These dysregulations modulate key cancer outcomes such as apoptosis, epithelial-mesenchymal transition (EMT), invasion, migration, cell cycle, and proliferation, contributing to cancer development.
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- The study investigates the expression of pro-caspase-3 and cleaved caspase-3 in luteinized granulosa cells during in vitro fertilization.
- Pro-caspase-3 was found to be positive in 77% of cells, while cleaved caspase-3 was only present in 4%, indicating pro-caspase-3’s predominant role.
- The expression of pro-caspase-3 was consistent regardless of patient characteristics or CASP3 mRNA levels, suggesting it's always ready for activation to regulate apoptosis during ovarian stimulation.
The quality of oocytes depends on interactions with surrounding granulosa cells. Granulosa cells are essential in normal follicular maturation process since they produce steroidal hormones and growth factors, and they play a crucial role in follicular atresia. The success in reproductive biology and medicine depends on reliable assessment of oocyte and embryo viability which presently mainly bases on oocyte and embryo morphology.
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