Publications by authors named "Felipe Eduardo Valencise"
We are presenting an overview of the retracted clinical trials about the Coronavirus Disease (COVID)-19 published in PubMed using the descriptors ((COVID-19 OR SARS-CoV-2) AND (Clinical Trial)). We collected the information for i) the first author's country; ii) the journal name where the study was published; iii) the impact factor of the journal; iv) the main objective of the study; v) methods including population, intervention, study design, and outcomes; and vi) results and conclusions. We collected complete information from the retraction notes published by the journals and the number of publications/retractions related to non-COVID-19 clinical trials published simultaneously.
View Article and Find Full Text PDFProfile of coronavirus disease enlightened asthma as a protective factor against death: An epidemiology study from Brazil during the pandemic.
Front Med (Lausanne)
November 2022
Introduction: The possibility that asthma is not a risk factor for the worst outcomes due to coronavirus disease (COVID-19) is encouraged. The increase in Th2 response dominance can downregulate the late phase of hyperinflammation, which is typically the hallmark of more severe respiratory viral infections, alongside lower angiotensin-converting enzyme receptors in patients with asthma due to chronic inflammation. Few studies associated asthma diagnosis and COVID-19 outcomes.
View Article and Find Full Text PDFCharacterization of Clinical Features of Hospitalized Patients Due to the SARS-CoV-2 Infection in the Absence of Comorbidities Regarding the Sex: An Epidemiological Study of the First Year of the Pandemic in Brazil.
Int J Environ Res Public Health
July 2022
Article Synopsis
- Higher severity and mortality rates in COVID-19 are linked to male patients, attributed to a mix of genetic, hormonal, and social factors.
- A study analyzing 336,463 patients in Brazil found male patients exhibited more severe symptoms and a greater need for intensive care compared to female patients.
- While being male slightly increased the risk of death (OR = 1.041), factors like older age had a much stronger impact on mortality prediction.
The Human Development Index measures a region's development and is a step for development debate beyond the traditional, economic perspective. It can also determine the success of a country's response to the COVID-19 pandemic, mainly affecting the case fatality rate among severe cases of SARS-CoV-2 infection. We aimed to associate the Human Development Index with the case fatality rate due to COVID-19 in each Brazilian state and the Federal District, taking into account comorbidities and the need for invasive mechanical ventilation.
View Article and Find Full Text PDFArticle Synopsis
- The COVID-19 pandemic led to increased usage of sedatives and analgesics, particularly opioids, in treating severe patients, but their necessity and overuse were debated.
- A literature review assessed opioid use during the pandemic, focusing on their role in procedures like intubation and the management of pain, while also examining the implications for patients in Brazil.
- The findings highlighted both the benefits and risks of opioids, particularly concerning respiratory depression and the impact on individuals with opioid use disorder, and noted the limited availability of opioids in Brazil's healthcare system.