Manifestations of walking fatigability in people with multiple sclerosis based on gait quality and distance walked during the six minutes walking test.

Background: Distance walking fatigability (DWF) in people with multiple sclerosis (pwMS) is defined as a decrease in the distance walking over time. However, declines in gait quality (i.e.

Hemodynamics of the Frontopolar and Dorsolateral Pre-Frontal Cortex in People with Multiple Sclerosis During Walking, Cognitive Subtraction, and Cognitive-Motor Dual-Task.

Introduction: Higher cortical activity has been observed in people with multiple sclerosis (pwMS) during walking and dual-tasking. However, further studies in overground walking and considering pre-frontal cortex (PFC) sub-areas are necessary.

Objectives: To investigate PFC activity during a cognitive-motor dual-task (DT) and its single component tasks, in combination with behavioral outcomes in pwMS.

Between-Day Reliability of the Gait Characteristics and Their Changes During the 6-Minute Walking Test in People With Multiple Sclerosis.

Background: Gait characteristics and their changes during the 6-minute walking test (6MWT) in people with multiple sclerosis (pwMS) have been described in the literature, which one may refer to as walking fatigability in the body function level of the International Classification of Functioning, Disability, and Health. However, whether these metrics are reliable is unknown.

Objective: To investigate the between-day reliability of the gait characteristics and their changes in pwMS and healthy controls (HCs).

Postural control of prolonged standing in people with Parkinson's disease.

People with Parkinson's disease (pwPD) have reduced adaptability to postural control during prolonged standing compared to neurologically healthy individuals (control). Objective. The study aimed to characterize postural changes during prolonged standing and their effect on postural control in pwPD compared to control.

The Blood Concentration of Metallic Nanoparticles Is Related to Cognitive Performance in People with Multiple Sclerosis: An Exploratory Analysis.

The imbalance in the concentration of metallic nanoparticles has been demonstrated to play an important role in multiple sclerosis (MS), which may impact cognition. Biomarkers are needed to provide insights into the pathogenesis and diagnosis of MS. They can be used to gain a better understanding of cognitive decline in people with MS (pwMS).

(A)symmetry during gait initiation in people with Parkinson's disease: A motor and cortical activity exploratory study.

Background: Gait asymmetry and deficits in gait initiation (GI) are among the most disabling symptoms in people with Parkinson's disease (PwPD). Understanding if PwPD with reduced asymmetry during GI have higher asymmetry in cortical activity may provide support for an adaptive mechanism to improve GI, particularly in the presence of an obstacle.

Objective: This study quantified the asymmetry of anticipatory postural adjustments (APAs), stepping parameters and cortical activity during GI, and tested if the presence of an obstacle regulates asymmetry in PwPD.

A multiple domain postural control assessment in people with Parkinson's disease: traditional, non-linear, and rambling and trembling trajectories analysis.

Background: Postural impairment is one of the most debilitating symptoms in people with Parkinson's disease (PD), which show faster and more variable oscillation during quiet stance than neurologically healthy individuals. Despite the center of pressure parameters can characterize PD's body sway, they are limited to uncover underlying mechanisms of postural stability and instability.

Research Question: Do a multiple domain analysis, including postural adaptability and rambling and trembling components, explain underlying postural stability and instability mechanisms in people with PD?

Method: Twenty-four individuals (12 people with PD and 12 neurologically healthy peers) performed three 60-s trials of upright quiet standing on a force platform.

Is BDNF related to spatial-temporal gait parameters in people with multiple sclerosis? An observational study.

Background: It has been suggested that the protein Brain-derived Neurotrophic Factor (BDNF) plays a neuroprotective role in people with multiple sclerosis (pwMS). Also, BDNF seems to play a role in cognition performance. In the same line, gait in pwMS requires a higher cognitive resource, mainly during complex walking.

Ankle muscle fatigability impairs body sway for more than 24 h.

This study aimed to investigate if the impairing in postural control, induced by ankle fatiguing exercise, remains after 24/48 h in young adults. Center of Pressure (CoP) was assessed in 16 participants (23 ± 3 years old) before, immediately after an ankle fatigability induction protocol (FI) and after 24 or 48 h of recovery using two 60-s trials with eyes open (EO) and closed (EC). The FI consisted of performing the ankle plantar flexion and dorsiflexion movement repeatedly (0.

Cortical activity and gait parameter characteristics in people with multiple sclerosis during unobstructed gait and obstacle avoidance.

Background: People with Multiple Sclerosis (PwMS) present higher cortical activity during walking. However, the cortical activity during gait while avoiding an obstacle is still not clear.

Objective: To investigate cortical activity and gait spatial-temporal parameters in PwMS during two different gait tasks (i.

Motor strategy during postural control is not muscle fatigue joint-dependent, but muscle fatigue increases postural asymmetry.

The aim of this study was to investigate the effects of ankle and hip muscle fatigue on motor adjustments (experiment 1) and symmetry (experiment 2) of postural control during a quiet standing task. Twenty-three young adults performed a bipedal postural task on separate force platforms, before and after a bilateral ankle and hip muscle fatigue protocol (randomized). Ankle and hip muscles were fatigued separately using a standing calf raise protocol (ankle fatigue) on a step and flexion and extension of the hip (hip fatigue) sitting on a chair, at a controlled movement frequency (0.

Step length synergy while crossing obstacles is weaker in patients with Parkinson's disease.

Background: Impaired movement stability is a common symptom of Parkinson's disease (PD) that leads to falls and mishandled objects. Decline in synergistic stabilization of movement in PD patients has been observed in manual and postural tasks. However, locomotor synergies have not been quantified in PD patients.

Prolonged Standing Task Affects Adaptability of Postural Control in People With Parkinson's Disease.

Background: Studies on short-term upright quiet standing tasks have presented contradictory findings about postural control in people with Parkinson's disease (pwPD). Prolonged trial durations might better depict body sway and discriminate pwPD and controls.

Objective: The aim of this study was to investigate postural control in pwPD during a prolonged standing task.

Saccadic eye movements are able to reduce body sway in mildly-affected people with Multiple Sclerosis.

Background: Multiple Sclerosis (MS) is a neurodegenerative and inflammatory disease that impacts both visual and postural control. It is currently unknown how the integration between visual and postural control is affected in people with MS (PwMS). It has been shown in healthy individuals that saccadic eye movements can decrease body sway as result as the integration of eye and postural movements.

Influence of obstacle color on locomotor and gaze behaviors during obstacle avoidance in people with Parkinson's disease.

The color of an obstacle may enable a more detailed view of the environment to facilitate obstacle avoidance. However, people with Parkinson's disease (PD) present visual contrast and color detection dysfunction, which could affect obstacle avoidance according to obstacle color. Thus, the aim of this study was to investigate the influence of obstacle color on locomotor and gaze behavior during obstacle avoidance in people with PD and neurologically healthy older individuals.