Publications by authors named "Felipe Araneda"
Article Synopsis
- Ventricular arrhythmias, linked to sudden cardiac death, are more prevalent in obese individuals, with a study showing that a high-fat diet (HFD) leads to obesity and increased arrhythmias in mice.
- The research found that RyR2 calcium release channels in the hearts of obese mice were more active and altered at the molecular level, indicating redox modifications due to fewer free thiol residues.
- Administering apocynin to the HFD-fed mice not only prevented arrhythmias but also normalized RyR2 activity and thiol content, highlighting a redox-dependent mechanism as a key factor in the increased arrhythmias associated with obesity.
Background: Persistent hyperlactatemia is particularly difficult to interpret in septic shock. Besides hypoperfusion, adrenergic-driven lactate production and impaired lactate clearance are important contributors. However, clinical recognition of different sources of hyperlactatemia is unfortunately not a common practice and patients are treated with the same strategy despite the risk of over-resuscitation in some.
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