Publications by authors named "Felipe A Morales-Martinez"
Harms of third- and fourth-generation combined oral contraceptives in premenopausal women: A systematic review and meta-analysis.
J Investig Med
December 2023
Article Synopsis
- The study reviewed the health impacts of third- and fourth-generation combined oral contraceptives on premenopausal women, analyzing both randomized controlled trials and observational studies.
- Findings showed that fourth-generation contraceptives led to lower LDL cholesterol levels and reduced risk of arterial thrombosis compared to third-generation options, although changes in total cholesterol varied by type.
- Overall, while there were benefits in lipid profiles and thrombosis risk with the newer generation pills, the evidence for other health outcomes remained unclear.
The Effects of Preimplantation Genetic Testing for Aneuploidy (PGT-A) on Patient-Important Outcomes in Embryo Transfer Cases: A Meta-Analysis.
J Reprod Infertil
January 2022
Article Synopsis
- - The study aimed to assess how preimplantation genetic testing for aneuploidy (PGT-A) affects reproductive outcomes after in vitro fertilization (IVF).
- - Ten studies involving 2630 embryo transfers were analyzed, showing no significant overall improvement in live birth or miscarriage rates with PGT-A, but a potential benefit for older women.
- - The authors recommend caution in promoting PGT-A for all couples since the benefits may not outweigh the costs for everyone, particularly those not of advanced maternal age.
Subfertility is commonly observed in patients with rheumatoid arthritis (RA). Although the causes are not well established, the alteration of the ovarian reserve is thought to contribute to the lower chances of pregnancy. This cross-sectional study aimed to evaluate the ovarian reserve in patients with RA.
View Article and Find Full Text PDFSystemic lupus erythematosus (SLE) is a chronic multisystem autoimmune disorder where the disease activity itself and the medications used for its treatment, may have adverse effects on ovarian function. This study aimed to assess the ovarian reserve (OR) in SLE patients. The anti-müllerian hormone (AMH) and the antral follicle count (AFC), two markers to evaluate the OR was assessed in 64 SLE patients and compared to normal individuals.
View Article and Find Full Text PDFThe Effect of Post warming Culture Period Between Thawing and Transfer of Cryopreserved Embryos on Reproductive Outcomes After In Vitro Fertilization (IVF): A Systematic Review and Meta-analysis.
J Reprod Infertil
January 2021
Background: The purpose of this study was to evaluate the effect of post warming culture period between thawing and transfer of cryopreserved embryos on reproductive outcomes after in vitro fertilization (IVF).
Methods: An extensive literature search was performed using PubMed, EmBase, and the Cochrane library from January 2000 to August 2019. A systematic review and meta-analysis of clinical trials was performed in this manuscript.
Background: The ovarian function and therefore the ovarian reserve may be compromised by the pathogenesis of autoimmune diseases of which, Hashimoto's thyroiditis (HT) is the most common in women of reproductive age. Furthermore, a prolonged reduction in thyroid hormone concentration results in a broad spectrum of reproductive alteration. Previous reports in the literature have been controversial regarding the impact of hypothyroidism and alterations in the ovarian reserve.
View Article and Find Full Text PDFObjective:: Investigate the possible effect of an acute sildenafil dose in asthenozoospermic patients.
Methods:: We ran this experimental, descriptive, prospective and non-blinded study in 32 patients diagnosed with asthenozoospermia according to the WHO criteria, after two consecutive semen analyses (samples 1 and 2), and we asked them to provide a new semen sample two weeks after the initial exams (sample 3). One hour prior to the semen collection, we gave the patients 100mg oral sildenafil.
To determine if the elimination of fragments in cleavage-stage embryos, before fresh transfer, improves pregnancy rates in fertilization cycles. This is a Prospective observational case-control study carried out at a University Reproductive Center. We included Twenty-six infertile patients divided into two groups.
View Article and Find Full Text PDFObjective: To identify the effect of apoptotic sperm elimination with MACS in patients that require IVF.
Methods: An experimental, cross-sectional, descriptive, prospective and non-blinded study of diagnostic tests performed in patients who required IVF and ICSI from July 2011 to July 2012. Ninety-two couples participated according to the treatment administered to the semen sample; in the control group: the samples were subjected only to density gradients before ICSI, in the study group: the same procedure was performed plus the addition of the MACS technique.
Background. Although the association between human chorionic gonadotropin (hCG) and hyperandrogenism was identified more than 40 years ago, relevant questions remain unanswered. Design and Methods.
View Article and Find Full Text PDFObjective: To demonstrate the capacitance stages acquired by the spermatozoa after the in vivo contact with the endometrium and the human cervical canal.
Study Type: Experimental, prospective, and longitudinal.
Materials And Methods: Spermatozoa obtained from the cervix and endometrium, plus post-capacitated semen in a 1 and 4 hours process, from couples that have proved fertility, were processed to evaluate motility, morphology, vitality and identification of morphological patterns with chlortetracycline and then inducted to acrosomal reaction with ionophore A23187.