Publications by authors named "Felicity H Inkpen"
Article Synopsis
- Fragile X syndrome (FXS) is linked to intellectual disability and autism, with cognitive inflexibility being a key feature; a rat model (Fmr1) was used to study this.
- In a novel environment, Fmr1 rats' neuronal activity in the hippocampus showed less adaptability over time compared to wild-type rats, indicating issues in learning and memory.
- The study points to abnormalities in the hippocampal circuitry of Fmr1 rats that may explain their behavioral deficits, although the exact connection remains to be investigated further.
Background: Mutations in the postsynaptic transmembrane protein neuroligin-3 are highly correlative with autism spectrum disorders (ASDs) and intellectual disabilities (IDs). Fear learning is well studied in models of these disorders, however differences in fear response behaviours are often overlooked. We aim to examine fear behaviour and its cellular underpinnings in a rat model of ASD/ID lacking Nlgn3.
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