Publications by authors named "Felicity F Noakes"
Article Synopsis
- The study investigates the biological effects of two water-soluble organic cations based on polypyridyl structures, finding that they have cytotoxic effects on cancer cells while being less harmful to noncancerous cells.
- One of the cations shows enhanced effectiveness when exposed to visible light, allowing it to operate at very low concentrations, and is more easily internalized by cells compared to its less effective counterpart.
- The active compound causes lysosomal swelling and disrupts mitochondrial function, leading to cell death through mechanisms like necrosis and apoptosis, yet shows no significant toxicity in animal models at tested levels.
With the aim of developing photostable near-infrared cell imaging probes, a convenient route to the synthesis of heteroleptic Os complexes containing the Os(TAP) fragment is reported. This method was used to synthesize the dinuclear Os complex, [{Os(TAP)}tpphz] (where tpphz = tetrapyrido[3,2-a:2',3'-c:3″,2''-h:2‴,3'''-j]phenazine and TAP = 1,4,5,8- tetraazaphenanthrene). Using a combination of resonance Raman and time-resolved absorption spectroscopy, as well as computational studies, the excited state dynamics of the new complex were dissected.
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