The study examined how different vaccination schedules with a Cuban outer membrane protein-based vaccine affect the immune memory and antibody response in mice.
Results showed that a booster shot given 7 months after initial vaccination increased antibody levels and highlighted a dose-dependent response, with more doses leading to a stronger primary response but less boost effect on bactericidal antibodies.
It was noted that a minimum of three doses were needed to enhance the IgG avidity, and a higher number of shots expanded the specificity of the antibody response, particularly towards the PorA protein.