Electron microscopy analysis of skin biopsies in CADASIL disease.

Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) is an inherited vascular disorder, non-amyloid and non-atherosclerotic, affecting predominantly the central nervous system. We examined samples of skin biopsies from six patients (men, 43-52-year-old), admitted for treatment in the Neurology Clinic regarding the presence of partial motor impairment on upper and lower right limbs, facial asymmetry and phrasing impairment (three of the patients); These three patients had family history remarkable for early-onset strokes: mother and two brothers deceased by early strokes (40-50-year-old). Skin biopsy samples were fixed in glutaraldehyde and post-fixed in osmium tetroxyde.

[Clinical and prognostic considerations in thalamic hemorrhage. Clinical study on 117 cases].

Unlabelled: Intracerebral hemorrhage located in the thalamus is one of the most frequent forms of hemorrhagic stroke in hypertensive patients. In this study the authors investigated the most important aspects related to thalamic hemorrhage : risk factors, initial signs, neurologic and EEG findings, the prognostic impact of the presence or absence of ventricular penetration, as well as the extension of hematoma.

Material And Method: 117 patients with thalamic hemorrhage confirmed by cerebral computerized tomography were included in the study.

[Psychocognitive impairment evaluation in early post-stroke period].

Unlabelled: There are many interconnections between pathological mechanism involved in production of dementia and cognitive impairment even in stroke patients. Early detection and management of these disorders provide better prevention of possible dementia.

Aim: To explore the factors which can affect psychocognitive impairment of poststroke patients.

[Neuropsychological disturbances in thalamic hemorrhage--clinical study].

Unlabelled: Neuropsychological disturbances are frequently associated with hemorrhagic stroke of the thalamus.

Material And Method: We present our personal findings on 117 patients admitted in the Ist Neurological Clinic, laşi with hemorrhagic stroke of the thalamus.

Results: Transcortical aphasia for the left-sided strokes and anosognosia or hemi-neglect were among the most prominent clinical features, especially for large thalamic hemorrhage.

Mechanical ventilation in vascular coma patients.

Vascular coma is one of the leading complications in patients suffering cerebrovascular accidents and it is therefore entirely appropriate that we should consider what critical care has to offer in this devastating disease process. Vascular coma patients need ventilatory assistance; Intubation and mechanical ventilation represent a life saving intervention. As critical care is subjected to progressive changes, careful definition of the role of mechanical ventilation, its types, and the ability of such a form of life sustaining support to affect patient outcome in multi-sided directions is mandatory.

Cheyne stokes respiration in stroke patients.

Cerebral-vascular events represent a major cause of mortality worldwide. Resulting respiratory complications are common and possibly composing a marker of severe neurological disorder. Cheyne-Stokes respiration is a disorder characterised by recurrent central apnoeas during sleep, alternating with a crescendo-decrescendo pattern of tidal volume, thus constituting an additional burden to the patient.

[Prospective epidemiologic and clinical observations on the prevalence of risk factors for stroke, performed on 374 inpatients, during the period of June 2001-June 2004].

Unlabelled: Within the framework of cardiovascular pathology, with an epidemopandemic aspect, the stroke, through its mortality and sequels, represents, worldwide, a major problem of community health. In this context, we present the results of an epidemiological and clinical study, both prospective and interdisciplinary, performed on a sample of 374 inpatients suffering from stroke, hospitalized in the Neurology Ist Clinic of Iaşi, during the period June 2001-June 2004. The characteristics of the studied sample: age--78.

[Acute myocardial infarction with neurological symptoms: clinical and pathologic aspects].

A variety neurological symptoms can be the onset of an acute myocardial infarction. The study includes 96 patients who have undergone necropsies (from 1978 to 2003), hospitalized at the "Sfânta Treime" University Hospital, Iaşi, in the Neurology Clinic. They were admitted for various neurological manifestations: hemiparesis, hemiplegia, aphasia, coma of the 1st degree up to the 4th.

[Absence seizure--recent physiopathologic data].

The progresses in clarifying the normal and pathologic cellular and molecular mechanisms are reflected in the elucidation of the way some of the most common forms of generalized seizure--absence seizures--occur and are produced. Intrinsic properties of the thalamic neurons that give them the ability to release or preserve oscillatory, low-frequency neuronal discharges, and the thalamo-cortical feedback mechanism seem to explain the pathogenesis of absence seizures. The involvement of GABA receptors in the regulation of membrane calcium channels, as well as their genetically-induced changes are new pieces in the pathogenic puzzle.