Publications by authors named "Fekih L"

Article Synopsis
  • A study assessed the efficacy and safety of a new eye drop (T2769) for dry eye patients, involving 62 participants treated for 42 days.
  • The results showed a significant improvement in ocular symptoms, with a notable reduction in discomfort and a high satisfaction rate among patients.
  • T2769 was well tolerated, with minimal side effects and considerable improvement in all evaluated symptoms by the end of the study.
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Introduction: Anti-tumor necrosis factor α (anti-TNF α) agents are an effective treatment for a variety of inflammatory and autoimmune diseases. In ophthalmology anti-TNF α began to emerge as a possible therapy for non-infectious uveitis, paradoxically their administration may result in the onset or recurrence of inflammatory eye disease such as uveitis. We reported a case of new onset of bilateral anterior and intermediate uveitis in a patient with rheumatoid arthritis (RA) while being treated with infliximab and we performed a review of literature.

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Article Synopsis
  • - Wernicke encephalopathy (WE) is a serious brain disorder caused by a lack of vitamin B1 (thiamine), with key symptoms including eye movement problems, altered mental status, and lack of coordination.
  • - It is commonly seen in individuals with alcoholism or malnutrition, but its link to severe morning sickness during pregnancy (hyperemesis gravidarum) is often overlooked.
  • - A case of a 24-year-old pregnant woman with hyperemesis gravidarum and vision issues led to a diagnosis of WE with optic nerve involvement, and her symptoms improved significantly following thiamine treatment, highlighting the need for prompt diagnosis and treatment.
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Purpose: To study the epidemiological and clinical characteristics of intermittent exotropia and to describe our therapeutic choices as well as their results and prognostic factors.

Materials And Methods: This was a retrospective study including 57 cases of intermittent exotropia. All patients underwent a complete ophthalmological examination with a sensory-motor assessment.

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Purpose: The purpose of this study was to analyze the retinal vasculature of diabetic eyes without clinical retinopathy in order to detect microvascular abnormalities, comparing them to that of healthy nondiabetic control eyes.

Methods: This is a prospective, cross-sectional study including 40 patients (76 eyes). Twenty patients (40 eyes) were diabetics with no diabetic retinopathy group (NDRG).

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Background: The professional driver's post is a security post that requires a careful assessment of the visual functions influencing the medical fitness decision. Professional driving benefits from a codified regulation regarding vision disorders. However, it suffers from several shortfalls making the task of the occupational doctor sometimes difficult.

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Background: Infantile esotropia is characterized by a significant deviation angle and a marked sensory perversion. Although the motor surgical results are satisfactory, the sensory results remain disappointing.

Aim: Our work aims to describe the methods of surgical management, its motor and sensory results as well as its prognostic factors.

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Introduction: Sensory exotropia is often due to profound amblyopia. Surgery essentially aims to improve aesthetic appearance and quality of life. Our goal was to discuss clinical features of sensory exotropia as well as surgical indications and outcomes.

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Introduction: Pulmonary Sarcomatoid Carcinoma (PSC) is a rare group of tumors accounting for about 0.4% of non-small cell lung carcinoma (NSCLC). Five subtypes were described: pleomorphic carcinoma, spindle cell carcinoma, carcinosarcoma, giant cell carcinoma and pulmonary blastoma.

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To evaluate the clinical improvement in ocular symptoms and signs in patients suffering from anterior blepharitis after using a novel cleansing wipe impregnated with 2.5% terpinen-4-ol and 0.2% hyaluronic acid.

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Intellectual disability (ID) is frequently associated as a comorbidity in autism spectrum disorders (ASD). This study investigated a) how similar the heterogeneity in the cognitive and socio-emotional developmental profiles was for children with ASD and ID, b) the difference between the subjects' profiles and those of typically developing children (TD) matched for developmental levels, c) the skills existing with the lowest and highest developmental levels, and d) the relationship between developmental profiles in ASD and the severity of autism, ID, and the overall developmental level. The sample was comprised of 119 children (101 boys and 18 girls) who ranged in chronological age (CA) from 21 months to 14 years ( = 5 years 2 months; SD = 2 years 6 months) with developmental levels lower than 24 months.

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Purpose: To describe the relationship between central serous chorioretinopathy (CSCR) and stress in addition to the transient and permanent professional repercussions of this condition among security forces agents.

Material And Methods: This is a retrospective, descriptive study of 22 CSCR patients. All patients were interviewed to establish their job status, a stressful triggering event, the number of consultations, absenteeism, the duration of episodes, the number of days off, exemption from certain activities and professional reclassification.

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Background: the antiglaucomatous treatments interact with the ocular surface and can induce its alteration which may affect the therapeutic results Aim : to describe the interactions between the ocular surface and anti-glaucoma medications and to propose practical attitudes to prevent and manage this issue.

Methods: a retrospective study about 100 patients with a primary opened angle glaucoma treated with anti-glaucomatous drops containing preservatives. We performed an exhaustive examination of the ocular surface with fluorescein instillation to search superficial punctuate keratitis and to evaluate the break up time.

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Unlabelled: Backgroud: The fronto-ethmoidal mucocele is a benign condition leading commonly to limited eye movement or ocular pain but it could also induce visual acuity impairment by compressing the optic nerve Aim: To discuss, through a case report, different ophthalmologic manifestations of the fronto-ethmoidalmucocele. Reported case: A 46-years-old man with no general history consulted for a bilateral ocular redness and itching. He reported, however, a mild protrusion of his left globe evolving for oneyear.

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Introduction: Oculomotor palsy is one of the most frequent neuro-ophthalmologic complications of diabetic patients. It generates less interest in the literature than the other ocular manifestations. Our goal was to study the clinical, epidemiological, therapeutic and prognostic characteristics of oculomotor palsy in the diabetic.

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Purpose: This study compared the efficacy and safety of hyaluronic acid (HA)-trehalose, a new eyedrop containing trehalose (a natural bioprotectant) and HA, to an established formulation containing only HA.

Methods: This was a phase III, randomized, active-controlled, investigator-masked, multicenter study in France and Tunisia. In all, 105 adult patients (≥18 years) with moderate to severe dry eye disease (DED) received either HA-trehalose (n = 52) or HA (n = 53) 3-6 times per day for 84 days.

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Aim: To compare efficacy (intraocular pressure (IOP) reduction) and safety of preservative-free latanoprost (T2345) to benzalkonium chloride (BAK)-preserved latanoprost (BPL; Xalatan) in ocular hypertension (OHT) or primary open angle glaucoma (POAG) patients.

Methods: Prospective, international, multicentre, randomised, investigator-masked, parallel-group trial. After a wash-out period, POAG or OHT patients, previously managed by BPL monotherapy, randomly received T2345 or BPL (one drop into the affected eye(s)) once daily from D0 to D84.

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Background: Tobacco smoking is frequent in the world affecting 20 à 50% of the population but with a decrease in occidental countries due to a huge effort based on sensiblisation and anti-tobacco decisions.

Aim: To review the impact of tobacco on bronchopulmonary affections.

Methods: A narrative review of literature

Results: In the next future, yearly tobacco-related deaths could increase from 4.

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Background: Bronchopulmonary cancer is actually the first cancer in the world. In Tunisia, recent statistics are alarmous. The most bronchopulmonary cancer in tunisian series are diagnosis at metastatic states.

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