A Cross-Layer Game-Theoretic Approach to Resilient Control of Networked Switched Systems Against DoS Attacks.

This article investigates the resilient control strategies of networked switched systems (NSSs) against denial-of-service (DoS) attacks and external disturbance. In the network layer, both the defender and the attacker allocate energy over multiple channels. Considering the impact of switching characteristic in the physical layer on the network layer, a dynamic regulating factor is proposed to adjust the total energy of the defender.

Downregulation of MTHFD2 Inhibits Proliferation and Enhances Chemosensitivity in Hepatocellular Carcinoma via PI3K/AKT Pathway.

Background: Despite the substantial impact of methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) on cancer progression, its significance in the regulation of hepatocellular carcinoma (HCC) cell proliferation and chemosensitivity remains poorly defined.

Methods: We evaluated MTHFD2 expression in a total of 95 HCC tissues by immunohistochemistry and analyzed the association of MTHFD2 with clinicopathologic features. qRT-PCR and Western blotting were conducted to verify MTHFD2 expression levels.

A novel axis of circKIF4A-miR-637-STAT3 promotes brain metastasis in triple-negative breast cancer.

Among patients with triple-negative breast cancer (TNBC), distant metastasis is the leading cause of death. Our previous studies have shown that TNBC progression is greatly facilitated by circKIF4A, but uncertainty remains regarding its role in TNBC brain metastasis and the molecular mechanism. In this study, we found notable upregulation of circKIF4A in TNBC cell lines and brain metastases.

Graph-Based Restricted and Arbitrary Switching for Switched Positive Systems via a Weak CLCLF.

This article studies the stability problem of discrete-time switched positive linear systems (SPLSs) with marginally stable subsystems. Based on the weak common linear copositive Lyapunov function (weak CLCLF) approach, the switching property and the state component property are combined to ensure the asymptotic stability of SPLSs under three types of switching signals. First, considering the transfer-restricted switching signal described by the switching digraph, novel cycle-dependent joint path conditions are proposed in combination with state component digraphs.

Recent progress in the oxidative bromination of arenes and heteroarenes.

Oxidative bromination has been serving as a powerful tool for the synthesis of bromo-containing molecules, as this bromination strategy features environmental friendliness, high flexibility in reaction system design and wide abundance of bromide sources and oxidants. The past decade has witnessed a large number of efficient oxidative bromination reaction systems and novel brominated aromatics. This review summarizes recent developments in the field of oxidative preparation of bromoarenes and bromoheteroarenes covering from 2012 to 2022.

Bumpless Transfer Control for Switched Systems via a Dynamic Feedback and a Bump-Dependent Switching Law.

This article investigates the bumpless transfer (BT) control problem of switched systems with unmeasured states. Note that the control input signal of the switched system jumps when switching occurs, which may adversely affect the performance of switched systems. By introducing a modified state observer and an auxiliary continuous control signal, a novel description of the BT performance for the system is presented.

Polysaccharide determination and habitat classification for fresh with hyperspectral imagery and modified RBFNN.

This research aimed to study the visual and nondestructive detection of mannose (MN) and polysaccharides (DP) in by using hyperspectral imaging technology. In order to determine the MN and DP concentrations nondestructively, we built radial basis function neural network (RBFNN) models based on NIR spectra (874-1734 nm) with a novel chemometric method to calculate the radial bases. And excellent results with the coefficients of 0.

Efficacy and safety of butylphthalide as adjunctive therapy for vascular dementia: A protocol for systematic review and meta-analysis.

Background: Butylphthalide is widely used for the adjunctive treatment of vascular dementia; however, the clinical evidences are not well synthesized yet.

Methods: We proposed a systematic review and meta-analysis to evaluate the efficacy and safety of butylphthalide as adjunctive therapy for vascular dementia. Seven electronic databases (China National Knowledge Infrastructure, Wanfang database, Chongqing VIP database, China Biomedical Literature Database, Pubmed, EMBASE and Cochrane library) will be searched for eligible randomized controlled trials (RCTs).

[Preliminary use of HoloLens glasses in surgery of liver cancer].

To establish the preoperative three dimensional (3D) model of liver cancer, and to precisely match the preoperative planning with the target organs during the operation.
 Methods: The 3D model reconstruction based on magnetic resonance data, which was combined with virtual reality technology via HoloLens glasses, was applied in the operation of liver cancer to achieve preoperative 3D modeling and surgical planning, and to directly match it with the operative target organs during operation.
 Results: The 3D model reconstruction of liver cancer based on magnetic resonance data was completed.

MicroRNA-138 inhibits cell proliferation in hepatocellular carcinoma by targeting Sirt1.

MicroRNAs (miRNAs) are a family of small, non‑coding RNA molecules that are highly conserved across species and function as regulators of gene expression. In the present study, we revealed that miR-138 expression was at a low level while sirtuin type 1 (Sirt1) mRNA expression was at high level in hepatocellular carcinoma tissues and cell lines by using real-time PCR and western blot assays, and the functions of miR-138 were achieved via targeting of Sirt1 using luciferase reporter gene vector and RNA immunoprecipitation assays. Overexpression of miR-138 attenuated Sirt1 expression and inhibited cell proliferation by using CCK-8 and BrdU assays.

New Three-Component Bicyclization Leading to Densely Functionalized Pyrazolo[3,4-]thiazolo[3,2-]pyrimidines.

A novel three-component bicyclization for the efficient synthesis of densely functionalized pyrazolo[3,4-]thiazolo[3,2-]pyrimidines has been established from readily accessible aryl aldehydes, α-thiocyanate ketones and pyrazol-5-amines. The reaction pathway involves nucleophilic addition/ /6- bicyclization sequence, resulting in continuous multiple bond-forming events including C-N and C-C bonds to rapidly a molecular complexity.

Preparation and in vitro characterization of pluronic-attached polyamidoamine dendrimers for drug delivery.

Context: Polyamidoamine (PAMAM) dendrimers have attracted lots of interest as drug carriers. And little study about whether pluronic-attached PAMAM dendrimers could be potential drug delivery systems has been carried on.

Objective: Pluronic F127 (PF127) attached PAMAM dendrimers were designed as novel drug carriers.

Microwave-assisted multicomponent reaction in water leading to highly regioselective formation of benzo[f]azulen-1-ones.

Microwave-assisted three-component reaction has been established for the regioselective synthesis of benzo[f]azulen-1-ones. The reaction was performed in aqueous media under microwave irradiation by using readily available and inexpensive starting materials. A total of 38 examples were examined to show a broad substrate scope and good overall yields (70-89%).

Multicomponent synthesis of poly-substituted benzo[a]pyrano[2,3-c]phenazine derivatives under microwave heating.

A new one-pot two-step tandem synthesis of highly functionalized benzo[a]pyrano[2,3-c]phenazine derivatives via microwave-assisted multicomponent reactions of 2-hydroxynaphthalene-1,4-dione, diamines, aldehydes, and malononitrile is reported. The procedures are facile, avoiding time-consuming and costly syntheses, tedious workup, and purifications of precursors, as well as protection/deprotection of functional groups. The method is expected to find application in the combinatorial synthesis of biologically active compounds, since phenazine and chromene motifs have a broad spectrum of biological activities.

Partitioning and localization of environment-sensitive 2-(2'-pyridyl)- and 2-(2'-pyrimidyl)-indoles in lipid membranes: a joint refinement using fluorescence measurements and molecular dynamics simulations.

Fluorescence of environment-sensitive dyes is widely applied to monitor local structure and solvation dynamics of biomolecules. It has been shown that, in comparison with a parent indole fluorophore, fluorescence of 2-(2'-pyridyl)-5-methylindole (5M-PyIn-0) and 2-[2'-(4',6'-dimethylpyrimidyl)]-indole (DMPmIn-0) is remarkably sensitive to hydrogen bonding with protic partners. Strong fluorescence, observed for these compounds in nonpolar and polar aprotic solvents, is efficiently quenched in aqueous solution.

Design and study of Bi[1,8]naphthyridine ligands as potential photooxidation mediators in Ru(II) polypyridyl aquo complexes.

A series of 3,3'-polymethylene-bridged bi[1,8]naphthyridine (binap) ligands, 3a-c, are complexed with Ru(II) to afford [Ru(tpy)(3a-c)(H(2)O)](2+) where an uncomplexed nitrogen on 3a-c is situated so it can form a H-bond with the coordinated water. An additional complex involving [Ru(4'-NMe(2)tpy)(3b)(H(2)O)](2+) is also prepared. X-ray analyses of the [Ru(tpy)(3a,c)(H(2)O)](2+) complexes indicate well-organized H-bonds even when the binap is nonplanar.

Ruthenium(II) Complexes of 2-Aryl-1,10-phenanthrolines: Synthesis, Structure, and Photophysical Properties.

The synthesis, characterization, and photochemical investigation of a series of Ru(II) complexes having 2-phenyl- and 2,9-diphenyl substituted phenanthroline ligands are reported. Structural characterization of some of the complexes revealed that the phenyl substituents of the phenanthroline ligand are oriented nearly perpendicular to the phenanthroline ring and pi-stack with adjacent coordinated 2,2'-bipyridyl ligands. Most of the complexes are nonluminescent at room temperature, and temperature-dependent luminescence studies suggest nonradiative relaxation in solution is dominated by rapid thermally activated internal conversion from the initially populated (3)MLCT state to a ligand field (LF) state which decays rapidly to the ground state.