The external validation of Dallas Steatosis Index among Asian population: a useful tool for metabolic dysfunction-associated steatotic liver disease identification and prevention.

Background: The Dallas Steatosis Index (DSI) is a non-invasive tool (NIT) developed to detect the risk of metabolic dysfunction-associated steatotic liver disease (MASLD) in multi-ethnic populations, external validation in Asians has yet to be conducted. Therefore, we evaluated the ability of the DSI with the BMI classification of WPRO (DSI_WPRO) to identify MASLD in the Chinese population. In addition, we investigated the associations between the DSI_WPRO and the risk of MASLD in a longitudinal study.

Mmu_circ_0001148 promotes endothlial-mesenchymal transition via regulating miR-218-5p/JMY axis and drives progression of atherosclerosis.

Atherosclerosis (AS) is a common cardiovascular disease and responsible for the high mortality of cardiovascular emergencies. Circular RNAs (circRNAs) show a potential role in atherogenesis. We identified an aberrantly expressed circRNA (circ_0001148) in atherosclerotic tissues.

Atomic electronegativity-dependent intramolecular hydrogen bond and fluorescence characteristics of novel scaffold-based fluorophore: a TD-DFT study.

In this work, fluorescent properties and excited-state intramolecular proton transfer (ESIPT) processes of 2,5-bis(benzo[d]thiazol-2-yl)phenol (BTP) and its derivatives (BOP and BSeP) with different heteroatom atoms (O and Se) have been systematically explored by the density functional theory (DFT) and time-dependent DFT (TD-DFT) methods. The calculated absorption and fluorescence emission peaks agree well with the experimental values in acetonitrile. From the data of structures, topological parameters, reduced density gradient analyses, and infrared (IR) vibrational frequencies, the intramolecular hydrogen bonds (IHBs) of BTP and its derivatives are enhanced upon light-excitation.

Unveiling the effects of atomic electronegativity on the ESIPT mechanism and luminescence property of new coumarin benzothiazole Fluorophore: A TD-DFT exploration.

The excited-state intramolecular proton transfer (ESIPT) mechanism, photophysical properties of 8-(benzo[D] thiazole-2-yl)-7-hydroxy-2H-benzopyran-2-one (L-HKS) and the effect of O/Se atomic substitution on L-HKS have been studied in detail based on density functional theory (DFT) and time-dependent DFT (TD-DFT) methods. The S atom in the thiazole ring of L-HKS has been replaced by O/Se atom (denoted to L-HKO/L-HKSe) to analyze the effects of atomic electronegativity on the intramolecular H-bond, absorption/emission spectrum and ESIPT process. Through the analysis of series of calculated results, it can be found that the intramolecular H-bonds at normal form and tautomer form are enhanced and weakened in the S state, respectively, which is favorable to ESIPT process.