Lack of association between pretreatment glutamate/GABA and major depressive disorder treatment response.

Studies have shown gamma-amino-butyric acid (GABA) and Glx (a combination of glutamate and glutamine) to be altered in major depressive disorder (MDD). Using proton Magnetic Resonance Spectroscopy (H-MRS), this study aimed to determine whether lower pretreatment GABA and Glx levels in the medial frontal cortex, a region implicated in MDD pathophysiology, are associated with better antidepressant treatment response. Participants with MDD (N = 74) were antidepressant naïve or medication-free for at least three weeks before imaging.

High-loading Bi-MOF nanoparticles anchored on biomass waste-derived carbon for sensitive non-enzymic nitrite sensing.

A novel electrocatalyst based on loofah sponge-derived carbon-supported high-density Bi-MOF nanoparticles was designed and used for electrochemical nitrite detection. The use of conductive loofah sponge-derived carbon substrate to support Bi-MOF nanoparticles can not only accelerate electron transfer, thereby accelerating electrochemical reaction kinetics, but also effectively prevent the aggregation of MOF materials, promote the full exposure of MOF active sites, and improve electrochemical sensing performance. Benefitting from the synergy effect of conductive loofah sponge-derived carbon sustrate and highly loading Bi-MOF nanoparticles, the Bi-MOF-NPs/CLS electrode displayed high sensitivity of 190 µA cm mM, a wide linear range from 5 µM to 1.