Nano co-delivery of doxorubicin and plumbagin achieves synergistic chemotherapy of hepatocellular carcinoma.

Doxorubicin (DOX) is a chemotherapy drug used for hepatocellular carcinoma (HCC) treatment, but its effectiveness can be dramatically dampened by cancer cell chemoresistance. Signal transducer and activator of transcription 3 (STAT3) is implicated with drug resistance in a range of cancers (e.g.

Electrochemiluminescence Sensor Based on CeO Nanocrystalline for Hg Detection in Environmental Samples.

The excessive concentration of heavy-metal mercury ions (Hg) in the environment seriously affects the ecological environment and even threatens human health. Therefore, it is necessary to develop rapid and low-cost determination methods to achieve trace detection of Hg. In this paper, an Electrochemiluminescence (ECL) sensing platform using a functionalized rare-earth material (cerium oxide, CeO) as the luminescent unit and an aptamer as a capture unit was designed and constructed.

Facile electrochemiluminescence sensing platform based on GdO:Eu nanocrystals for organophosphorus pesticides detection in vegetable samples.

In this work, europium ion-doped gadolinium trioxide nanocrystals (GdO:Eu NCs) were successfully synthesized and applied to construct an electrochemiluminescence (ECL) sensor. Compared with pure GdO, the doping of Eu ions caused enhanced ECL intensity and more stable signals. Based on the excellent ECL performance of GdO:Eu NCs, we constructed a new ECL sensing platform for the detection of organophosphorus pesticides (OPs).

Electrochemiluminescence Aptasensor Based on Gd(OH) Nanocrystalline for Ochratoxin A Detection in Food Samples.

In the present study, the electrochemiluminescence (ECL) properties of Gd(OH) nanocrystals with KSO as the cathode coreactant were studied for the first time. Based on the prominent ECL behavior of this material and the excellent specificity of the aptamer technique, an ECL aptasensor for the detection of ochratoxin A (OTA) was formulated successfully. Over an OTA concentration range of 0.

Selective Detection of Alkaline Phosphatase Activity in Environmental Water Samples by Copper Nanoclusters Doped Lanthanide Coordination Polymer Nanocomposites as the Ratiometric Fluorescent Probe.

In this paper, a novel, accurate, sensitive and rapid ratiometric fluorescent sensor was fabricated using a copper nanoclusters@infinite coordination polymer (ICP), specifically, terbium ion-guanosine 5'-disodium (Cu NCs@Tb-GMP) nanocomposites as the ratiometric fluorescent probe, to detect alkaline phosphatase (ALP) in water. The fluorescence probe was characterized by scanning electron microscopy, transmission electron microscopy, X-ray photoelectron spectroscopy, and Fourier transform infrared spectroscopy. The experimental results showed that, compared with Tb-GMP fluorescent sensors, Cu ratiometric fluorescent sensors based on NCs encapsulated in Tb-GMP had fewer experimental errors and fewer false-positive signals and were more conducive to the sensitive and accurate detection of ALP.

An ultrasensitive electrochemiluminescence biosensor for the detection of total bacterial count in environmental and biological samples based on a novel sulfur quantum dot luminophore.

In this paper, the electrochemiluminescence (ECL) of sulfur quantum dots (SQDs) in a potassium persulfate cathodic co-reactant was studied. Based on the selective quenching of the ECL emission from the SQDs by β-nicotinamide adenine dinucleotide (NADH), an ultrasensitive ECL biosensor with NADH as an important parameter was established for the highly sensitive and selective detection of total bacterial count (TBC). A linear response between the ECL intensity and the NADH concentration in the range of 1 pM to 10 μM was obtained, thus achieving a detection limit of 1 pM.

Electrochemiluminescent determination of CYFRA21-1 serum levels using Ti-Fe-O nanotubes immunoassay.

Prominent electrochemiluminescence (ECL) in Ti-Fe-O nanotube arrays (Ti-Fe-O NTs) with KSO as the cathode coreactant is reported for the first time. Compared with pure titanium dioxide nanotubes (TiO NTs), this heterojunction could effectively reduce the band gap, facilitate electronic transitions, and move the ECL potential to a positive direction. The ECL performance motivated the development of an ultrasensitive ECL immunosensor for detecting cytokeratin fragment 21-1 (CYFRA21-1).

Molecular and quantitative trait variation within and among small fragmented populations of the endangered plant species Psilopeganum sinense.

Background And Aims: Natural selection and genetic drift are important evolutionary forces in determining genetic and phenotypic differentiation in plant populations. The extent to which these two distinct evolutionary forces affect locally adaptive quantitative traits has been well studied in common plant and animal species. However, we know less about how quantitative traits respond to selection pressures and drift in endangered species that have small population sizes and fragmented distributions.

Isolation and characterization of microsatellite loci in Psilopeganum sinense Hemsl (Rutaceae), an endangered herb endemic to Yangtze River valley.

Twenty-nine primer pairs flanking microsatellite repeats were designed from an AC-enriched genomic library of Psilopeganum sinense and tested using 24 individuals derived from a natural population. A total of 11 microsatellite loci were found polymorphic. The number of alleles per locus varied from two to eight, with an average value of 3.