Publications by authors named "Feiya Luo"
Article Synopsis
- The study examined how much lead (Pb), cadmium (Cd), and arsenic (As) can be absorbed from three types of traditional Chinese medicines (TCMs) and their decoctions using a specific digestion and cell model.
- A new risk assessment model was developed to evaluate the health risks associated with exposure to these heavy metals in TCMs, using a hazard index (HI) and a method for more detailed analysis called TTD.
- Results showed the bioavailability of these metals varied significantly, but overall health risks from TCMs were found to be acceptable based on adjusted HI outcomes, contributing to a better understanding of how to ensure safer TCM use for public health.
Article Synopsis
- The prevalence of Alzheimer's disease (AD) is rising, and current drugs cannot cure or slow it down.
- α-lipoic acid (LA), found in foods like spinach and meat, can potentially stabilize cognitive function in AD patients by reducing cell damage caused by the disease.
- The study shows that LA inhibits microglia toxicity and inflammation related to AD, suggesting a combination of anti-inflammatory and antioxidant treatments could be effective for managing the disease.
In the present study, the oral bioavailability of cadmium (Cd) in earthworms and leeches was investigated through in vitro physiologically based extraction test (PBET) digestion/Caco2 and MDKC cell models. We are the first to create an innovative assessment strategy which has capacity to offer a more precise evaluation of Cd-associated health risks in traditional animal medicines (TAMs), by combinational usage of bioavailable Cd levels, the duration and frequency of the exposure to TAMs obtained by questionnaire data, as well as safety factor of TAMs. Our data showed that the percentage of bioavailability for Caco-2 cells in earthworms and leeches ranged from 3.
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- The increase in Alzheimer's disease (AD) due to a growing elderly population puts a strain on society and families, as the disease significantly affects patients' daily lives.
- Research showed that alpha-lipoic acid (LA) can reduce toxicity caused by amyloid beta fragments (Aβ) in PC12 cells, highlighting its potential therapeutic role.
- LA helps protect cells by preventing apoptosis and restoring the function of the Wnt-β-catenin signaling pathway, which is disrupted by Aβ treatment.
Article Synopsis
- Antibiotics have been banned as feed additives since 1986, creating a need for safe alternatives, with essential oils (EOs) from plants being a promising option due to their bioactivity.
- Ten different essential oils were extracted and analyzed, leading to the identification of 123 chemical compounds, including various active organic substances.
- Certain EOs demonstrated strong antioxidant and antibacterial properties, suggesting they could be developed as effective feed additives in place of traditional antibiotics.
Few studies reported the extent of heavy metal accumulation in traditional Chinese medicines (TCMs). Currently, oral bioaccessibility of lead (Pb), cadmium (Cd), arsenic (As), mercury (Hg), and copper (Cu) present in traditional animal medicines was investigated with physiologically based extraction test-extracted in vitro model. We are the first to develop a health risk assessment strategy by combinational analysis of bioaccessible heavy metal levels to calculate target hazard quotient (THQ), target hazard index (THI) and cancer risk (CR), which has capacity to evaluate the heavy metal associated heath risk of traditional animal medicines.
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