The transformation pathways and optimization of conditions for preparation minor ginsenosides from Panax notoginseng root by the fungus Aspergillus tubingensis.

Minor ginsenosides exhibit enhanced pharmacological effects in comparison to the major ginsenosides. However, the natural content of minor ginsenosides in plants is typically insufficient to satisfy clinical demand. Therefore, we investigated the biotransformation of the major ginsenosides in Panax notoginseng to minor ginsenosides by the fungus Aspergillus tubingensis.

Five Unreported Ketone Compounds-Penicrustones A-E-From the Endophytic Fungus .

Five unreported ketone compounds-penicrustones A-E-were isolated from the solid fermentation of the endophytic fungus . Their structures were elucidated on the basis of extensive spectroscopic analysis. Their absolute configurations were determined via ECD calculations and single-crystal X-Ray crystallography.

Production of rare ginsenosides by biotransformation of Panax notoginseng saponins using Aspergillus fumigatus.

Panax notoginseng saponins (PNS) are the main active components of Panax notoginseng. But after oral administration, they need to be converted into rare ginsenosides by human gut microbiota and gastric juice before they can be readily absorbed into the bloodstream and exert their effects. The sources of rare ginsenosides are extremely limited in P.

Secondary metabolites from the fungus .

A new cladosporol derivative xylophilum A (), together with 10 known compounds (-), were isolated from the rice fermentation of the fungus . Their structures were established by extensive spectroscopic methods and comparison of their NMR data with literatures. The antimicrobial activity of compound against 11 kinds of pathogenic microbial was evaluated, but no significant activity was found (MIC >100 μg/ml).

Adsorption Mechanism and Regeneration Performance of Calcined Zeolites for Hydrogen Sulfide and Its Application.

Hydrogen sulfide (HS) is a very toxic, acidic, and odorous gas. In this study, a calcined zeolite was used to investigate the adsorption performance of HS. Among particle size, calcination temperature and time calcination temperature and time had significant effects on the adsorption capacity of HS on the zeolite.

A new illudane sesquiterpene from the edible fungus .

Fungi have different genetic expression abilities and biosynthetic pathways under different cultivation conditions, which can produce various secondary metabolites. The "one strain many compounds" strategy is used to activate silent biosynthetic genes of fungi to produce various compounds, which is an effective method. In order to discover various new compounds in the edible fungus , a fermentation strategy involving precursor feeding and enzyme inhibitor addition has been employed.

Correlation Between Intracoronary Vascular Ultrasound Indexes in Patients with Coronary Heart Disease.

Background: Coronary atherosclerosis is a serious and progressive condition characterized by the accumulation of plaques, consisting of fat, cholesterol, and other substances, within the arteries that supply blood to the heart. These plaques can harden and narrow the arteries, leading to reduced blood flow to the heart muscle.

Objective: The primary objective of this study is to investigate the correlation between specific cardiovascular parameters and intracoronary vascular ultrasound indexes in patients diagnosed with coronary heart disease.

The effect of dapagliflozin on anemia in elderly patients with heart failure by bioinformatics analysis.

Background: Anemia associated with heart failure is frequent and can exacerbate the symptoms of heart failure. Dapagliflozin is the first SGLT-2 inhibitor with significant cardiovascular protection. However, the effect of dapagliflozin on anemia in elderly patients with heart failure is unknown.

Prognostic effect of atrial fibrillation on survival in patients with hypertrophic cardiomyopathy: a meta-analysis.

Objective: To systematically evaluate the prognostic impact of atrial fibrillation (AF) in patients with hypertrophic cardiomyopathy (HCM).

Methods: The Chinese and English databases (PubMed, EMBASE, Cochrane Library, Chinese National Knowledge Infrastructure, and Wanfang database were systematically searched to include observational studies on the prognosis of AF in cardiovascular events or death in patients with HCM; these were evaluated using Revman 5.3.

Evaluation of ABC Bleeding Score and SAMe-TT2R2 Score on the Risk of Bleeding after Anticoagulation in Patients with Nonvalvular Atrial Fibrillation Complicated with Coronary Heart Disease.

Objective: To explore the predictive value of ABC bleeding score and SAMe-TT2R2 score on the risk of bleeding in patients with nonvalvular atrial fibrillation (NVAF) complicated with coronary heart disease (CHD) after anticoagulation.

Methods: 149 patients with NVAF complicated with CHD were followed up in our hospital for one year. The bleeding events during the follow-up period were observed, the ABC bleeding score and SAMe-TT2R2 score were calculated, the predictive value of the two scoring methods for the main bleeding risk was analyzed by the ROC curve, and the AUC area under the ROC curve of the two scoring methods was compared by the Delong test.

Association between T-tau protein and Aβ42 in plasma neuronal-derived exosomes and cognitive impairment in patients with permanent atrial fibrillation and the role of anticoagulant therapy and inflammatory mechanisms.

Background: This study explores whether the differences in cognitive performance among individuals with permanent atrial fibrillation (AF) are attributable to the duration of AF and anticoagulant therapy and explores the possible inflammatory mechanism of cognitive dysfunction related to AF.

Methods: A total of 260 patients aged 50-75 years without previous cerebrovascular events were enrolled in this study. These 260 patients had been divided into the AF group (140 patients) and sinus rhythm group (120 patients).

IVUS plus multivariate analysis for evaluating the stability of coronary artery plaque in coronary heart disease.

Objective: To investigate the effect of intravascular ultrasound (IVUS) plus multivariate analysis in evaluating the stability of coronary artery plaque in coronary heart disease (CHD).

Methods: A retrospective analysis was conducted on ninety-five patients with CHD admitted to our hospital from February 2020 to February 2021. Patients with CHD were examined by IVUS and assigned to a stable plaque group (n=60) and an unstable plaque group (n=35) according to their characteristics.

Plasma miR-22-5p, miR-132-5p, and miR-150-3p Are Associated with Acute Myocardial Infarction.

Circulating microRNAs (miRNAs) are potential biomarkers for cardiovascular diseases. Our study aimed to determine whether miR-22-5p, miR-132-5p, and miR-150-3p represent novel biomarkers for acute myocardial infarction (AMI). Plasma samples were isolated from 35 AMI patients and 55 matched controls.