Publications by authors named "Feiteng Zhu"
Objectives: Using a random forest algorithm, we previously found that teicoplanin-associated gene A (tcaA) might play a role in resistance of methicillin-resistant Staphylococcus aureus (MRSA) to β-lactams, which we have investigated further here.
Methods: Representative MRSA strains of prevalent clones were selected to identify the role of tcaA in the MRSA response to β-lactams. tcaA genes were deleted by homologous recombination in the selected MRSA strains, and antibiotic susceptibility tests were applied to evaluate the effect of tcaA on the minimum inhibitory concentrations (MICs) of glycopeptides and β-lactams.
Objectives: Fosfomycin has regained attention for treating infections caused by methicillin-resistant Staphylococcus aureus and multidrug-resistant coagulase-negative staphylococci. In this research, our objective was to investigate the mechanisms underlying fosfomycin resistance in Staphylococcus capitis.
Methods: The minimum inhibitory concentrations (MICs) of fosfomycin were assessed in 109 clinical S.
Profiling daptomycin resistance among diverse methicillin-resistant lineages in China.
Antimicrob Agents Chemother
November 2023
Daptomycin (DAP) is effective against methicillin-resistant (MRSA). However, reduced susceptibility to DAP in MRSA may lead to treatment failures. We aim to determine the distribution of DAP minimum inhibitory concentrations (MICs) and DAP heteroresistance (hDAP) among MRSA lineages in China.
View Article and Find Full Text PDFBackground: The overuse of antibiotics in livestock is contributing to the burden of antimicrobial resistance in humans, representing a One Health challenge. Livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) has recently become a growing concern, and ST9 is the major LA-MRSA lineage in China and has emerged in clinical settings.
Methods: Antimicrobial susceptibility testing was used to evaluate the tetracycline resistance of ST9 MRSA collections, and gene cloning experiments were performed to explore the resistance mechanisms.
Background: Surgical sites infections (SSIs) caused by Methicillin-resistant (MRSA) constitute a major clinical problem. Understanding the transmission mode of MRSA is important for its prevention and control.
Aim: We investigated the transmission mode of a MRSA outbreak in a trauma and orthopedic hospital ward.
Objectives: Given the increasing frequency of infections due to extended-spectrum β-lactamase (EBSL)-producing Klebsiella pneumoniae in humans over recent decades, infection control against this pathogen is of high importance.
Methods: In this study, the transmission mode of ESBL-producing K. pneumoniae in neonatal intensive care units (NICU) was investigated.
Staphylococcus capitis, which causes bloodstream infections in neonatal intensive care units, is a common cause of healthcare-associated infections. Thus, a standardized high-resolution typing method to document the transmission and dissemination of multidrug-resistant S. capitis isolates is required.
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- * Most MRSA isolates were susceptible to BPR, with significant differences in susceptibility based on strain type and SCCmec classification, where certain types showed higher susceptibility.
- * The study identified potential genetic mutations in BPR-resistant isolates and highlighted nanopore sequencing as a valuable tool for uncovering resistance mechanisms in MRSA, raising concerns about the emergence of resistant strains.
The novel fosfomycin resistance gene fosY is present on a genomic island in CC1 methicillin-resistant .
Emerg Microbes Infect
December 2022
Fosfomycin has gained attention as a combination therapy for methicillin-resistant infections. Hence, the detection of novel fosfomycin-resistance mechanisms in is important. Here, the minimal inhibitory concentrations (MICs) of fosfomycin in CC1 methicillin-resistant were determined.
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- The study aimed to analyze the genetic structure of Tn1546-like elements in methicillin-resistant Staphylococcus aureus (MRSA) strains collected in mainland China from 2013 to 2015.
- Out of 271 MRSA isolates, 64 (23.6%) were identified as Tn1546-positive, predominantly belonging to the CC59 clone, while two were from a different clone (CC5-ST965), both showcasing multidrug resistance.
- The findings emphasize the presence of multiple Tn1546-like elements within these MRSA strains and highlight the need for continuous monitoring to prevent the spread of antibiotic resistance.
The Role of Mutations in Seesaw Effect of Daptomycin-Resistant Methicillin-Resistant Staphylococcus aureus Isolates.
Antimicrob Agents Chemother
January 2022
The emergence of daptomycin-resistant (DAP-R) Staphylococcus aureus strains has become a global problem. Point mutations in are the main cause of daptomycin (DAP) treatment failure. However, the impact of these specific point mutations in methicillin-resistant S.
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- Treatment of methicillin-resistant Staphylococcus aureus (MRSA) infections is challenging due to limited therapeutic options, but a combination of penicillin and potassium clavulanate (PENC) shows potential.
- Researchers conducted a study to analyze MRSA isolates' susceptibility to PENC and developed a prediction model for identifying susceptible strains using their genomic data.
- The created machine learning model exhibited high accuracy (up to 94%) in predicting PENC susceptibility, despite some isolates having resistant phenotypes, highlighting the complexity of accurately determining drug resistance.
Household Transmission of Community-Associated Methicillin-Resistant .
Front Public Health
July 2021
Currently, the mechanism of community-associated methicillin-resistant (CA-MRSA) transmission mechanism is unclear; however, it must be considered in conjunction with asymptomatic strains colonization dynamics. This epidemiological study aimed to determine the role of the household in CA-MRSA transmission in China. Five patients with culture-confirmed CA-MRSA infection and five control patients were recruited from the Sir Run Run Shaw Hospital in Zhejiang, China, between December 2019 and January 2020.
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- The study aimed to explore the genomic epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) in China, focusing on predominant lineages and their connection to clinical data and resistance profiles.
- Over 1900 patients with S. aureus infections were analyzed, with 40% having MRSA, primarily from three key lineages: CC239, CC5, and CC59, the latter accounting for most community-associated MRSA cases.
- Findings revealed that more than half of the MRSA isolates showed genetic features indicating increased susceptibility to penicillin, suggesting that using combinations of penicillins and β-lactamase inhibitors could enhance antibiotic treatment strategies in the region.
Purpose: To determine the genetic characteristics of the Chinese epidemic ST5-SCCmec II-t311 methicillin-resistant Staphylococcus aureus (MRSA) clone and to investigate the transmission characteristics of the cfr-positive plasmid.
Methods: The complete genome of SR153 was sequenced. Genomic comparison with MRSA strains of other lineages was performed.