Effects of glucocorticoid on cyclic nucleotide-gated channels of olfactory receptor neurons.

Objective: Cyclic adenosine monophosphate (cAMP) and cyclic nucleotide-gated (CNG) channels play an important role in olfactory perception. The purpose of this study was to explore the effect of glucocorticoid on the CNG channels of olfactory receptor neurons (ORNs).

Methods: For in vivo studies, rats were injected with dexamethasone 1 mg/kg body weight intraperitoneally once or once a day for 2 weeks.

[Effect of Betamethasone on the cAMP of olfactory receptor neurons in rat].

Objective: To observe the effects of Betamethasone on the cyclic adenosine monophosphate (cAMP) in olfactory receptor neurons (ORNs) and explore the possible mechanisms of the recovery of olfactory disorders by steroid treatment

Methods: ORNs membrane was extracted and incubated with 0.1 mg/ml and 1.0 mg/ml Betamethasone.

[Clinical features of primary ciliary dyskinesia].

Objective: To investigate the clinical features, diagnosis and treatment of primary ciliary dyskinesia (PCD).

Methods: Three cases of PCD received endoscopic sinus surgery and were followed up for life quality and recovery. Among these 3 cases, two were twin brothers and the other girl was twin born with a healthy brother.

[Influence of breast carcinoma cells on normal endothelial cells: experimental study with a co-culture system].

Objective: To study the influence of breast carcinoma cells on normal endothelial cells.

Methods: Human endothelial cells were isolated from umbilical cord blood. Medium Z-MCF-7-EC was established and was used to co-culture the normal endothelium cells (ECs) and human breast cancer cells of the line MCF-7.