Recent advances in analysis of new psychoactive substances by means of liquid chromatography coupled with low-resolution tandem mass spectrometry.

The number of methods for the analysis of new psychoactive substances (NPS) is continually increasing, and there is no indication that this trend will change in the near future. The constantly growing market of "designer drugs" makes it necessary to develop new methods of their analysis. The aim of this review is to present the multi-component methods of detection and identification of NPS using low-resolution tandem mass spectrometry coupled with liquid chromatography.

Opportunities for visible supercontinuum light generation in integrated diamond waveguides.

We numerically show the advantages of using diamond-on-insulator (DOI) waveguides to design compact supercontinuum (SC) light sources for the visible (VIS) wavelength range. We conclude that the DOI platform is more suitable than silicon nitride waveguides for tailoring the dispersion in such a way that a zero-dispersion wavelength (ZDW) is obtained in the VIS, as is required to achieve efficient VIS SC generation (SCG). After designing a DOI waveguide that features a ZDW at ∼600  nm, we exploit it to numerically obtain a smooth SC ranging from 453 nm to 1030 nm above the -30  dB point after propagation over 4 mm.

Degradation of 4-aminobenzenesulfonate by a two-species bacterial coculture. Physiological interactions between Hydrogenophaga palleronii S1 and Agrobacterium radiobacter S2.

The mutualistic interactions in a 4-aminobenzenesulfonate (sulfanilate) degrading mixed bacterial culture were studied. This coculture consisted of Hydrogenophaga palleronii strain S1 and Agrobacterium radiobacter strain S2. In this coculture only strain S1 desaminated sulfanilate to catechol-4-sulfonate, which did not accumulate in the medium but served as growth substrate for strain S2.

Syntrophic interactions during degradation of 4-aminobenzenesulfonic acid by a two species bacterial culture.

During synthrophic growth of Hydrogenophaga palleronii (strain S1) and Agrobacterium radiobacter (strain S2) with 4-aminobenzene sulfonate (4ABS) only strain S1 desaminates 4ABS by regioselective 3,4-dioxygenation. The major part of the metabolite catechol-4-sulfonate (4CS) is excreted and further metabolized by strain S2. Although both organisms harbour activities of protocatechuate pathways assimilation of the structural analog 4CS requires first of all enzyme activities with broader substrate specificity: protocatechuate 3,4-dioxygenase and carboxymuconate cycloisomerase activities were identified which in addition to the natural substrates also convert 4CS and 3-sulfomuconate respectively.