Monoamine oxidase B inhibits epithelial-mesenchymal transition and trigger apoptosis via targeting ERK1/2 signaling pathway in head and neck squamous cell carcinoma.

Background: Monoamine oxidase B (MAOB), a flavin monoamine oxidase, regulates biogenic and xenobiotic amine oxidative deaminization. We demonstrate MAOB expression in head and neck epithelium and its biological importance in head and neck squamous cell carcinoma (HNSCC) development.

Methods: First, we found a possible MAOB downregulation in HNSCC using bioinformatic analysis.

Qi-Zhi-Wei-Tong granules alleviates chronic non-atrophic gastritis in mice by altering the gut microbiota and bile acid metabolism.

Ethnopharmacological Relevance: In traditional Chinese medicine, Qi-zhi-wei-tong granule (QZWT) significantly reduced the major gastrointestinal and psychological symptoms of functional dyspepsia.

Aim Of The Study: We aimed to explore the therapeutic effect of QZWT treated chronic non-atrophic gastritis (CNAG) and to elucidate its potential mechanism.

Materials And Methods: The composition of QZWT was analysed by UPLC-Q/TOF-MS.

The bHLH-zip transcription factor SREBP regulates triterpenoid and lipid metabolisms in the medicinal fungus Ganoderma lingzhi.

Ganoderic acids (GAs) are well recognized as important pharmacological components of the medicinal species belonging to the basidiomycete genus Ganoderma. However, transcription factors directly regulating the expression of GA biosynthesis genes remain poorly understood. Here, the genome of Ganoderma lingzhi is de novo sequenced.

Characteristics of the Genome, Transcriptome and Ganoderic Acid of the Medicinal Fungus .

Ganoderma (Ganodermaceae) is a genus of edible and medicinal mushrooms that create a diverse set of bioactive compounds. Ganoderma lingzhi has been famous in China for more than 2000 years for its medicinal properties. However, the genome information of G.

hsa_circ_0000264 promotes tumor progression via the hsa-let-7b-5p/HMGA2 axis in head and neck squamous cell carcinoma.

Objective: Circular RNAs (CircRNAs) are involved in various tumors. However, their role in head and neck squamous cell carcinoma (HNSCC) is unknown. CircRNA sequencing data showed that hsa_circ_0000264 is significantly upregulated in HNSCC tissues.

Dual antioxidant activity and the related mechanisms of a novel pentapeptide GLP4 from the fermented mycelia of .

Oxidative stress causes chronic inflammation, and mediates various diseases. The discovery of antioxidants from natural sources is important to research. Here we identified a novel antioxidant peptide (GLP4) from mycelium and investigated its antioxidant type and potential protective mechanisms.

CD73 facilitates invadopodia formation and boosts malignancy of head and neck squamous cell carcinoma via the MAPK signaling pathway.

Elevated adenosine generated by CD73 (ecto-5'-nucleotidase; NT5E) could boost immunosuppressive responses and promote immune evasion in the tumor microenvironment. However, despite the immune response, CD73 could also promote tumor progression in a variety of cancers, and the nonimmunologic role and corresponding molecular mechanism of CD73 involved in head and neck squamous cell carcinoma (HNSCC) progression are not well characterized. Here, we demonstrated that CD73/NT5E is overexpressed in HNSCC tissues and predicts poor prognosis.

Extracellular Matrix Characterization in Gastric Cancer Helps to Predict Prognosis and Chemotherapy Response.

The extracellular matrix (ECM) plays a central role in the formation of the tumor microenvironment. The deposition of the ECM is associated with poor prognosis in a variety of tumors. Aberrant ECM deposition could undermine the effect of chemotherapy and immunotherapy.

CLPTM1L Is a Novel Putative Oncogene Promoting Tumorigenesis in Oral Squamous Cell Carcinoma.

This study aimed to explore the function of CLPTM1L in oral squamous cell carcinoma and mechanism of tumorigenesis. The expression of CLPTM1L was detected by immunohistochemistry. The localization in cells was detected by immunofluorescence.

Identification of enhancer RNAs for the prognosis of head and neck squamous cell carcinoma.

Background: Enhancer RNAs (eRNAs) play an important role in carcinogenesis. The landscape of eRNAs in head and neck squamous cell carcinoma (HNSCC) remains largely unknown.

Methods: The eRNA expression matrix was obtained from the enhancer RNA in the cancer database.

The Identification of Stemness-Related Genes in the Risk of Head and Neck Squamous Cell Carcinoma.

Objectives: This study aimed to identify genes regulating cancer stemness of head and neck squamous cell carcinoma (HNSCC) and evaluate the ability of these genes to predict clinical outcomes.

Materials And Methods: The stemness index (mRNAsi) was obtained using a one-class logistic regression machine learning algorithm based on sequencing data of HNSCC patients. Stemness-related genes were identified by weighted gene co-expression network analysis and least absolute shrinkage and selection operator analysis (LASSO).

Digitoxin inhibits proliferation of multidrug-resistant HepG2 cells through G/M cell cycle arrest and apoptosis.

Hepatocellular carcinoma (HCC) remains a challenge in the medical field due to its high malignancy and mortality rates particularly for HCC, which has developed multidrug resistance. Therefore, the identification of efficient chemotherapeutic drugs for multidrug resistant HCC has become an urgent issue. Natural products have always been of significance in drug discovery.

Combine contrast-enhanced 3D T2-weighted short inversion time inversion recovery MR neurography with MR angiography at 1.5 T in the assessment of brachial plexopathy.

Purpose: To explore the benefits of using a single injection of contrast agent at a 1.5 T system to perform both contrast-enhanced MR angiography (MRA) and 3D-T2-STIR MR neurography (MRN) to assess of brachial plexopathy.

Methods: In this prospective study, 27 patients with suspected brachial plexopathy, received an imaging procedure composed sequentially of non-enhanced 3D-T2-STIR, CE-MRA, and contrast-enhanced 3D-T2-STIR, using a 1.

Digitoxin inhibits HeLa cell growth through the induction of G2/M cell cycle arrest and apoptosis in vitro and in vivo.

Cervical cancer is the fourth most common gynecological malignancy affecting the health of women worldwide and the second most common cause of cancer‑related mortality among women in developing regions. Thus, the development of effective chemotherapeutic drugs for the treatment of cervical cancer has become an important issue in the medical field. The application of natural products for the prevention and treatment of various diseases, particularly cancer, has always attracted widespread attention.

Synergistic Adsorption for Parabens by an Amphiphilic Functionalized Polypropylene Fiber with Tunable Surface Microenvironment.

A series of novel amphiphilic functionalized fibers with polarity tunable surface microenvironment were constructed by introducing hydrophilic polyamines and hydrophobic linear alkyl chain groups, aiming to selectively remove parabens from water. In addition, Fourier-transform infrared spectroscopy, X-ray powder diffraction, scanning electron microscopy, etc. were employed to determine the successful preparation of amphiphilic functionalized fibers.

A Novel Approach for Imaging of Thoracic Outlet Syndrome Using Contrast-Enhanced Magnetic Resonance Angiography (CE-MRA), Short Inversion Time Inversion Recovery Sampling Perfection with Application-Optimized Contrasts Using Different Flip Angle Evolutions (T2-STIR-SPACE), and Volumetric Interpolated Breath-Hold Examination (VIBE).

BACKGROUND The aim of this study was to introduce a novel method combining contrast-enhanced magnetic resonance angiography (CE-MRA), short inversion time inversion recovery sampling perfection with application-optimized contrasts using different flip angle evolutions (T2-STIR-SPACE) and volumetric interpolated breath-hold examination (VIBE) sequences in the assessment of thoracic outlet syndrome (TOS). MATERIAL AND METHODS CE-MRA, T2-STIR-SPACE, and VIBE techniques were employed to evaluate neurovascular bundles in 27 patients clinically suspected of TOS. Images were evaluated to determine the cause of neurovascular bundle compression.

Residual micro organic pollutants and their biotoxicity of the effluent from the typical textile wastewater treatment plants at Pearl River Delta.

This work investigated the biotoxicity and the residual dissolved organic matter (DOM) of the effluents from nine typical full-scale textile plants located at Pearl River Delta (PRD) in Guangdong province, China. The fluorescence regional integration (FRI) analysis showed that the tryptophan-like (II), soluble microbial product-like (IV) and fulvic acid-like substances (III) were the dominant compounds in the DOM. The acute toxicity test showed toxic effects still remained in most textile effluents, which might attribute to the undegraded dyes or aromatic compounds.

Synthesis of yolk-shell mesoporous silica nanoparticles via a facile one-pot approach.

A facile one-pot method is proposed for the fabrication of yolk-shell mesoporous silica nanoparticles with high special surface area. The particle size can be well controlled by moderately tuning some experimental parameters.

Effects of copolymer composition, film thickness, and solvent vapor annealing time on dewetting of ultrathin block copolymer films.

Effects of copolymer composition, film thickness, and solvent vapor annealing time on dewetting of spin-coated polystyrene-block-poly(methyl methacrylate) (PS-b-PMMA) films (<20nm thick) were mainly investigated by atomic force microscopy. Surface chemical analysis of the ultrathin films annealed for different times were performed using X-ray photoelectron spectroscopy and contact angle measurement. With the annealing of acetone vapor, dewetting of the films with different thicknesses occur via the spinodal dewetting and the nucleation and growth mechanisms, respectively.

Controllable synthesis of hollow mesoporous silica particles by a facile one-pot sol-gel method.

A simple and facile one-pot sol-gel method is proposed for the fabrication of hollow mesoporous silica particles. Both the particle size and the shell thickness can be well controlled by moderately tuning some experimental parameters.

Constructional details of polystyrene-block-poly(4-vinylpyridine) ordered thin film morphology.

One of the most important issues for spin-coated diblock copolymer thin films is to distinguish the blocks by common techniques, especially for the diblock copolymers containing one block could form active domain. Aiming different estimations on the composition of surface microdomains in polystyrene-block-poly (4-vinylpyridine) (PS-b-P4VP) atomic force microscope (AFM) phase images, AFM, transmission electron microscopy, and droplet shape analyzer were used to identify the constructional details of the polymer thin film morphology. It was confirmed that PS block is harder than P4VP block in symmetric PS-b-P4VP films and corresponds to brighter regions in AFM phase image.