Preparation of nanosilver/polymer composites and evaluation of their antimicrobial and antitumor effect.

In this study, a copolymer (PVA--PEG) of polyethylene glycol (PEG) and polyvinyl alcohol (PVA) was synthesized by grafting PEG chains onto PVA backbone. PVA--PEG was used as the carrier to prepare the silver nanoparticles/polymer composite (AgNPs/PVA--PEG) using a "one-pot" biological method in the presence of grape seeds extract as a reducing and stabilizing agent. In order to highlight the effect of the copolymer, the homo-polymers PVA and PEG were applied as the carriers to prepare the corresponding composites - AgNPs/PVA, and AgNPs/PEG, respectively using the same method.

Hot-Carrier Extraction Prevailing over Multiple-Exciton Generation in Two-Dimensional Semiconductor Heterostructures.

Multiple-exciton generation (MEG) represents an effective strategy to break the Shockley-Queisser (SQ) limit, thereby enhancing the efficiency of photon-to-electron conversion. Here, we investigate MEG in monolayer MoTe, with an energy threshold of 2.22 eV (∼2.

A molecular module improves rice grain quality and yield at high temperatures.

Excessive temperatures during grain filling can compromise endosperm starch biosynthesis and decrease grain quality and yield in rice. However, the molecular mechanisms underlying these remain unclear. Here, we show that heat shock protein OsHsp40-1 interacts with and elevates the ATPase activity of OsHsp70-2 in rice.

Assessment of dermal safety of petroleum ether extract from L.

(), known for its aromatic leaves and rhizomes, is extensively used in traditional medicine to treat digestive issues, inflammation, pain, anxiety, and stress. The petroleum ether extract of isolates specific bioactive compounds using petroleum ether, a nonpolar solvent effective in dissolving nonpolar plant compounds. This extract potentially offers antimicrobial, anti-inflammatory, and analgesic benefits.

A novel transcription factor OsMYB73 affects grain size and chalkiness by regulating endosperm storage substances' accumulation-mediated auxin biosynthesis signalling pathway in rice.

Enhanced grain yield and quality traits are everlasting breeding goals. It is therefore of great significance to uncover more genetic resources associated with these two important agronomic traits. Plant MYB family transcription factors play important regulatory roles in diverse biological processes.

The pro-tumor activity of INTS7 on lung adenocarcinoma via inhibiting immune infiltration and activating p38MAPK pathway.

Lung adenocarcinoma (LUAD) is the most common lung cancer, accounting for 19.4% of all cancer deaths. Our previous study discovered that INTS7 expression was upregulated in LUAD, while the precise mechanism by which INTS7 exerts pro-cancer effects remains unknown.

APEX1 Knockdown Alleviates Inflammation and Fibrosis in Myocardial Infarction Through Promoting ZCCHC9 Expression and Blocking the p38 MAPK Signaling.

It was reported that serum apurinic/apyrimidinic endodeoxyribonuclease 1 (APEX1) level was higher in acute myocardial infarction (AMI) patients than in angina. This study aimed to investigate the role and mechanism of APEX1 in AMI progression. The mRNA and protein levels of APEX1 and zinc finger CCHC domain containing 9 (ZCCHC9) in blood specimens of AMI patients and normal controls were determined by RT-qPCR and Western blot assays, respectively.

Peimine induces apoptosis of glioblastoma cells through regulation of the PI3K/AKT signaling pathway.

Glioblastoma (GBM) is one of the most malignant forms of intracranial tumors, with high mortality rates and invariably poor prognosis, due to the limited clinical treatment strategies available. As a natural compound, peimine's favorable pharmacological activities have been widely revealed. However, potential inhibitory effects of peimine on GBM have not been explored.

Effects of 10 KM run on foot morphology and bilateral symmetry in male recreational runners.

Foot morphology and arch integrity do not remain constant during a running bout. Previous studies have reported inconsistent changes in foot sizes and arch parameters and this discrepancy may be related to the variation in their test duration, e.g.

-Y262C mutation causes abnormal zona pellucida formation and female infertility in humans.

Defective oocyte maturation is a common cause of female infertility. The loss of the zona pellucida (ZP) represents a specific condition of impaired oocyte maturation. The extracellular matrix known as the ZP envelops mammalian oocytes and preimplantation embryos, exerting significant influence on oogenesis, fertilization, and embryo implantation.

Research on overburden structural characteristics and support adaptability in cooperative mining of sectional coal pillar and bottom coal seam.

In the mining process of the II1 coal seam at Zhaogu No. 2 coal mine, a method of stratified mining is employed, leaving relatively wide coal pillars in sections. To enhance the resource recovery rate, the mine carries out the cooperative mining of the sectional coal pillars and the lower layer coal seam.

Isorhamnetin: what is the evidence for its antitumor potential and beyond?

Isorhamnetin (ISO) is a phenolic compound belonging to flavonoid family, showcasing important pharmacological activities such as antitumor, anti-inflammation, and organ protection. ISO is predominantly extracted from . This plant is well-known in China and abroad because of its "medicinal and food homologous" characteristics.

OsLESV and OsESV1 promote transitory and storage starch biosynthesis to determine rice grain quality and yield.

Transitory starch is an important carbon source in leaves, and its biosynthesis and metabolism are closely related to grain quality and yield. The molecular mechanisms controlling leaf transitory starch biosynthesis and degradation and their effects on rice (Oryza sativa) quality and yield remain unclear. Here, we show that OsLESV and OsESV1, the rice orthologs of AtLESV and AtESV1, are associated with transitory starch biosynthesis in rice.

Candidate Gene Identification and Transcriptome Analysis of Tomato - and Functional Marker Development for - and Its Alleles, -, -, and -.

Male sterility is a valuable trait for hybrid seed production in tomato (). The mutants - (-) and - of tomato exhibit twisted stamens, exposed stigmas, and complete male sterility, thus holding potential for application in hybrid seed production. In this study, the - and - loci were fine-mapped to 53.

Zeaxanthin impairs angiogenesis and tumor growth of glioblastoma: An in vitro and in vivo study.

Objectives: To investigate the therapeutic effects of Zeaxanthin (Zea), one of the oxidized xanthophyll carotenoids belonging to the isoprenoids, on inhibiting the angiogenesis and tumor growth of glioblastoma (GBM) via an in vitro and in vivo study.

Methods: The effects of Zea on the proliferation, adhesion, migration and invasion of human GBM cell lines were detected by cell proliferation assay, cell adhesion assay and Transwell assay. The effect of Zea on angiogenesis was detected by rat aortic ring assay and human umbilical vein endothelial cells (HUVEC) in vitro tube formation assay.

Artificial Intelligence in Liver Diseases: Recent Advances.

Liver diseases cause a significant burden on public health worldwide. In spite of great advances during recent years, there are still many challenges in the diagnosis and treatment of liver diseases. During recent years, artificial intelligence (AI) has been widely used for the diagnosis, risk stratification, and prognostic prediction of various diseases based on clinical datasets and medical images.

Disruption of LPA-LPAR1 pathway results in lung tumor growth inhibition by downregulating B7-H3 expression in fibroblasts.

Background: Lysophosphatidic acids (LPAs) belong to a class of bioactive lysophospholipids with multiple functions including immunomodulatory roles in tumor microenvironment (TME). LPA exerts its biological effects via its receptors that are highly expressed in fibroblasts among other cell types. As cancer-associated fibroblasts (CAFs) are a key component of the TME, it is important to understand LPA signaling and regulation of receptors in fibroblasts or CAFs and associated regulatory roles on immunomodulation-related molecules.

Observation on Short-Term Therapeutic Effect of Electroacupuncture on Compensatory Hypertrophy Of Gastrocnemius Muscle: A Retrospective Cohort Study.

Objective: In Oriental women, having thick and short legs is a common posture problem, and having an imperfect lower leg shape is one of the factors that can cause feelings of inferiority. To address this issue, a retrospective cohort study was conducted to investigate the effectiveness of electroacupuncture in improving compensatory hypertrophy of the gastrocnemius muscle while also reducing side effects. The goal of this study is to improve the clinical treatment plan for this type of problem.

Nrf2 signaling pathway: current status and potential therapeutic targetable role in human cancers.

Cancer is a borderless global health challenge that continues to threaten human health. Studies have found that oxidative stress (OS) is often associated with the etiology of many diseases, especially the aging process and cancer. Involved in the OS reaction as a key transcription factor, Nrf2 is a pivotal regulator of cellular redox state and detoxification.

14-Day Vonoprazan-Based Bismuth Quadruple Therapy for Treatment-Naïve Patients with Infection: A Retrospective Comparative Study.

Background: Until now, there is little evidence regarding clinical efficacy of 14-day vonoprazan-based bismuth quadruple therapy (BQT) for () eradication.

Methods: Overall, 65 treatment-naïve patients with H. pylori infection who received 14-day vonoprazan-based BQT regimen (VBCA, n=17) or pantoprazole-based BQT regimen (PBCA, n=48) for H.

Optical absorption enhancement in inhomogeneous InGaN nanowire arrays photocathode.

In the development of surface structures, nanowire arrays (NWAS) have been widely studied because of their trapping effect. In this paper, the finite difference time domain (FDTD) method is used to simulate homogeneous and inhomogeneous NWAS. We studied the influence of the structural parameters of InGaN NWAS and inhomogeneous arrays on optical response properties.

Acupoint Application Combined with Acupoint Massage for Treating Constipation in a Patient with Chronic Obstructive Pulmonary Disease.

Chronic obstructive pulmonary disease (COPD) is a common and frequent disease in elderly patients, with a tendency for progressive exacerbation. Constipation that reduces the quality of life and triggers the risk of diseases is a common concomitant symptom in patients with COPD. Currently, western medical treatment does not achieve the desired results for patients.