Publications by authors named "Feifan Liu"

Background: Malignant cerebral edema (MCE) is a significant complication following endovascular thrombectomy (EVT) in the treatment of acute ischemic stroke. This study aimed to develop and validate a deep learning-assisted diagnosis model based on the hyperattenuated imaging marker (HIM), characterized by hyperattenuation on head non-contrast computed tomography immediately after thrombectomy, to facilitate radiologists in predicting MCE in patients receiving EVT.

Methods: This study included 271 patients, with 168 in the training cohort, 43 in the validation cohort, and 60 in the prospective internal test cohort.

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: Tumor associated macrophages (TAMs) are critical components in regulating the immune statuses of the tumor microenvironments. Although TAM has been intensively studied, it is unclear how mitochondrial proteins such as AGK regulate the TAMs' function. : We investigated the AGK function in TAMs using macrophage-specific deficient mice with B16 and LLC syngeneic tumor models.

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Background: The global incidence of prostate cancer (PCa) is rising, necessitating improved diagnostic strategies. This study explores coagulation parameters' predictive value for clinically significant PCa (csPCa) and develops a nomogram.

Research Design And Methods: This study retrospectively analyzed data from 702 patients who underwent prostate biopsy at Shandong Provincial Hospital (SDPH) and 142 patients at Shandong Cancer Hospital and Institute (SDCHI).

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Article Synopsis
  • In chronic rhinosinusitis with nasal polyps (CRSwNP), inflammation is primarily driven by immune cells like T2 cells and eosinophils, but resistance to treatment often involves neutrophils, whose role is not well understood.* -
  • Research using advanced techniques, such as single-cell analysis, reveals an increased presence of a specific type of CD8 T cells called granzyme K (GZMK) CD8 T cells in nasal polyps, which interact with fibroblasts to produce neutrophil attractants.* -
  • The study suggests that GZMK distinguishes a unique subset of CD8 T cells that not only contributes to neutrophilic inflammation in CRSwNP but may also play a
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The (1→3)(1→6)-α-D-dextran (alternating dextran) produced by Leuconostoc citreum SK24.002 is a novel functional exopolysaccharide, and its low molecular weight derivatives have potential applications in the food, pharmaceutical, and chemical industries. In this work, we used sonication, a green polysaccharide disruption method, to study the degradation process of this dextran by changing the intensity and duration of the sonication treatment and the concentration of the dextran solution.

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Blue corona discharges are often generated in thunderclouds penetrating into the stratosphere and are the optical manifestation of narrow bipolar events (NBEs) observed in radio signals. While their production appears to depend on convection, the cause and nature of such discharges are not well known. Here we show the observations by a lightning detection array of unusual amounts of 982 NBEs during a tropical storm on the coastline of China.

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Background: Fried dough sticks, widely enjoyed in southeast Asia, are made by frying a mixture of wheat flour and water at high-temperature. With the move towards industrial production, there is an increasing demand for healthier versions. Understanding the key properties of fried dough sticks and how the ingredients interact is crucial for meeting these health-focused consumer preferences.

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Ethnopharmacological Relevance: Yajieshaba (YJSB), approved by the Yunnan Provincial Food and Drug Administration in 2008, are known for their anti-inflammatory, antiviral, and pro-apoptotic properties, effectively treating Hepatic fibrosis (HF). However, its mechanism of action remains unclear.

Aim Of The Study: The objective of this investigation is to explore how YJSB influences the TGF-β1/Smad signaling pathway as a strategy for reducing HF.

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  • Gouty nephropathy (GN) is a kidney condition caused by high uric acid levels due to factors like excessive purine intake and metabolic disorders, leading to crystal buildup in kidney tissue.
  • DaiTongXiao (DTX), a traditional remedy from the Dai people in China, shows promise in reducing uric acid levels and has anti-inflammatory and kidney-protective effects.
  • In a rat model of GN, DTX treatment improved kidney function and structure, decreased serum inflammatory markers, and inhibited the TLR4/MyD88/NF-κB signaling pathway, indicating its potential as a therapeutic option for GN.
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The fall armyworm (FAW) is a serious agricultural pest and has developed resistance to multiple insecticides. It is necessary to introduce novel insecticide(s) for controlling FAW. Isocycloseram is a completely novel isoxazoline insecticide.

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Background: The limitations of prostate-specific antigen (PSA) in diagnosing prostate cancer (PCa) necessitate the exploration of novel biomarkers. Recent studies suggest a potential link between coagulation markers, particularly fibrinogen and D-dimer, and PCa.

Methods: A retrospective single-center analysis on 466 biopsy-undergone patients was conducted, categorized into PCa and benign prostatic hyperplasia (BPH) groups.

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Ethnopharmacological Relevance: Allergic rhinitis (AR) stands as a non-infectious inflammatory condition affecting the nasal mucosa, marked by bouts of sneezing, nasal itching, and congestion. This ailment afflicts individuals across all age groups and poses challenges for effective treatment due to its chronic nature. Cangerzisan (CEZS), documented in the Jishengfang compendium, represents a traditional Chinese medicinal formula long utilized for AR management.

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  • Malignant cerebral edema (MCE) can occur after endovascular thrombectomy (EVT) for acute ischemic stroke (AIS), leading to serious health issues; this study aimed to create a prediction model for MCE using an imaging marker called hyperattenuated imaging marker (HIM).
  • The study involved 151 patients with large-vessel occlusion, using machine learning techniques to analyze clinical and imaging data and create a nomogram for predicting MCE likelihood.
  • Results showed that the nomogram had a high accuracy in predicting MCE, with an area under the curve (AUC) of 0.999 in the training group and 0.938 in the test group, suggesting it could be a valuable tool for
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Ethnopharmacological Relevance: Functional dyspepsia (FD) is a prevalent gastrointestinal disorder characterised by high incidence and recurrence rates, posing significant health risks. Erpixing Granules (EPX), approved by the National Food and Drug Administration in 2002, are known for their spleen and stomach invigorating properties, effectively treating FD. However, its mechanism of action remains unclear.

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  • * DTX treatment improved health outcomes by increasing body weight and decreasing harmful compounds like serum urate levels and indicators of kidney damage, while also enhancing uric acid excretion.
  • * The study found that DTX regulates specific transport proteins in the kidneys, downregulating GLUT9 and upregulating OAT1 and OAT3, which helps slow the progression of hyperuricemia.
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The present review expounds the advancements in the application and mechanisms of flavonoids in gouty arthritis, highlighting their significance in managing the disease. Gouty arthritis is among the most common and severe inflammatory diseases, caused by hyperuricemia and the deposition of sodium urate crystals in the joints and surrounding tissues, posing a serious threat to human life and health. Flavonoids, extracted from various herbs, have attracted significant attention due to their efficacy in improving gouty arthritis.

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Background: Error analysis plays a crucial role in clinical concept extraction, a fundamental subtask within clinical natural language processing (NLP). The process typically involves a manual review of error types, such as contextual and linguistic factors contributing to their occurrence, and the identification of underlying causes to refine the NLP model and improve its performance. Conducting error analysis can be complex, requiring a combination of NLP expertise and domain-specific knowledge.

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Background: The Delphi consensus identified 8 symptoms and 8 consequences as the highest priorities for defining low anterior resection syndrome.

Objective: To describe an exploratory scoring instrument correlating the Delphi consensus on low anterior resection syndrome with functional and quality-of-life scores following intersphincteric resection for ultralow rectal cancer.

Design: This was a prospective pilot study.

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Background: According to the World Health Organization (WHO), healthy aging is the process of developing and maintaining the functional capacity for health in old age. A rapidly growing number of research studies on healthy aging have been conducted worldwide. The purpose of this research work is to explore global scientific landscape of healthy aging research over the last 22 years.

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In this study, we investigated the drag reduction property of a premixed slurry drag reducer in a millimeter-scale pipe. The aim of this study is to establish the correlation between Darcy friction factor and drag reducer concentration (C) and volume flow (Q). First, the experimental plan was designed by using the response surface method (RSM), and then the experimental data were processed to establish the quadratic correlation between the response variable and the description variable.

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Patients with multiple myeloma (MM), an age-dependent neoplasm of antibody-producing plasma cells, have compromised immune systems and might be at increased risk for severe COVID-19 outcomes. This study characterizes risk factors associated with clinical indicators of COVID-19 severity and all-cause mortality in myeloma patients utilizing NCATS' National COVID Cohort Collaborative (N3C) database. The N3C consortium is a large, centralized data resource representing the largest multi-center cohort of COVID-19 cases and controls nationwide (>16 million total patients, and >6 million confirmed COVID-19+ cases to date).

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Background: Bladder cancer (BLCA) is the most common malignancy of the urinary system. Muscle-invasive bladder cancer (MIBC), which constitutes approximately 25% of all BLCA cases, is characterized by frequent recurrence and early onset of metastasis. Bladder cancer most commonly occurs in elderly patients and is significantly associated with aging.

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Purpose Of Review: Three biologics targeting type 2 inflammation have been approved for the treatment of severe and uncontrolled chronic rhinosinusitis with nasal polyps (CRSwNP). Nevertheless, around 40-60% of patients do not respond well to these biological treatments. Selecting appropriate patients is crucial to improve treatment outcome of biologics.

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Ethnopharmacological Relevance: DaiTongXiao (DTX) is a traditional Chinese Dai folk formulation utilized for gouty arthritis treatment, with substantial evidence supporting its anti-inflammatory properties. The NLRP3 inflammasome disorder is tightly linked to the development of many inflammatory diseases.

Aim Of The Study: To elucidate the therapeutic efficacy of DTX in gouty arthritis and reveal its potential underlying mechanism.

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Purpose: To determine whether anastomotic leakage (AL) following intersphincteric resection (ISR) for ultralow rectal cancer (uLRC) is associated with long-term negative outcomes.

Methods: Between June 2011 and January 2022, 236 consecutive patients who underwent ISR with diverting ileostomy for uLRC were included. The primary outcome was long-term clinical consequences of AL, including chronic stricture, stoma reversal, and oncological and functional results.

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