Microfluidic Electrospinning Core-Shell Nanofibers for Anti-Corrosion Coatings With Efficient Self-Healing Properties.

Self-healing materials have been extensively explored in metal anti-corrosion fields. However, improving the self-healing efficiency remains a significant work that severely limits their further development. Here, a strategy to fabricate anti-corrosion coatings with efficient self-healing properties based on microfluidic electrospinning technologies and UV-curable healing agents is reported.

Histone deacetylase inhibition enhances extracellular vesicles from muscle to promote osteogenesis via miR-873-3p.

Regular physical activity is widely recognized for reducing the risk of various disorders, with skeletal muscles playing a key role by releasing biomolecules that benefit multiple organs and tissues. However, many individuals, particularly the elderly and those with clinical conditions, are unable to engage in physical exercise, necessitating alternative strategies to stimulate muscle cells to secrete beneficial biomolecules. Histone acetylation and deacetylation significantly influence exercise-induced gene expression, suggesting that targeting histone deacetylases (HDACs) could mimic some exercise responses.

The influence of Type I and III collagen on the proliferation, migration and differentiation of myoblasts.

Myoblast is a kind of activated muscle stem cell. Its biological activities, such as proliferation, migration, differentiation, and fusion, play a crucial role in maintaining the integrity of the skeletal muscle system. These activities of myoblasts can be significantly influenced by the extracellular matrix.

Antenna-based optimization of triplet radioluminescence of Tb-organic complex scintillator for efficient X-ray detection.

Triplet exciton is both a luminescence quenching factor and an important luminescence sensitization technology solution, which is widely concerned in the field of optoelectronic materials. Since X-ray excited triplet excitons are dissipated through various pathways, there are still huge difficulties in achieving efficient triplet sensitized emission. Here, the antenna ligand is regulated through the carboxyl group, increasing the steric hindrance between the conjugated groups and improving triplet-enhanced radioluminescence (RL) efficiencies of Tb.

Establishment and validation of an artificial intelligence web application for predicting postoperative in-hospital mortality in patients with hip fracture: a national cohort study of 52 707 cases.

Background: In-hospital mortality following hip fractures is a significant concern, and accurate prediction of this outcome is crucial for appropriate clinical management. Nonetheless, there is a lack of effective prediction tools in clinical practice. By utilizing artificial intelligence (AI) and machine learning techniques, this study aims to develop a predictive model that can assist clinicians in identifying geriatric hip fracture patients at a higher risk of in-hospital mortality.

Effects of Endoscopic Sinus Surgery on Olfactory Bulb Volume among Patients with Chronic Rhinosinusitis: A Systematic Review and Meta-Analysis.

Background: Endoscopic sinus surgery (ESS) could significantly improve olfactory function among patients with chronic rhinosinusitis (CRS). This study aimed to perform a meta-analysis to evaluate the effect of ESS on the olfactory bulb volume (OBV) among patients with CRS.

Methods: A systemic search of PubMed, Medline, Embase, Web of Science, and other databases was conducted to identify studies assessing OBV changes in patients with CRS after ESS utilizing magnetic resonance imaging.

Cholestyramine alleviates bone and muscle loss in irritable bowel syndrome via regulating bile acid metabolism.

Irritable bowel syndrome (IBS) is a widespread gastrointestinal disorder known for its multifaceted pathogenesis and varied extraintestinal manifestations, yet its implications for bone and muscle health are underexplored. Recent studies suggest a link between IBS and musculoskeletal disorders, but a comprehensive understanding remains elusive, especially concerning the role of bile acids (BAs) in this context. This study aimed to elucidate the potential contribution of IBS to bone and muscle deterioration via alterations in gut microbiota and BA profiles, hypothesizing that cholestyramine could counteract these adverse effects.

CHRONIC CRITICAL ILLNESS-INDUCED MUSCLE ATROPHY: INSIGHTS FROM A TRAUMA MOUSE MODEL AND POTENTIAL MECHANISM MEDIATED VIA SERUM AMYLOID A.

Background: Chronic critical illness (CCI), which was characterized by persistent inflammation, immunosuppression, and catabolism syndrome (PICS), often leads to muscle atrophy. Serum amyloid A (SAA), a protein upregulated in critical illness myopathy, may play a crucial role in these processes. However, the effects of SAA on muscle atrophy in PICS require further investigation.

Association between cognition and olfaction-specific parameters in patients with chronic rhinosinusitis.

Background: Patients with chronic rhinosinusitis (CRS) have reported significantly cognitive and olfactory dysfunction. This study aimed to explore the relationship between cognitive function and olfaction-specific parameters in patients with CRS.

Methods: A cross-sectional survey method was used to investigate 98 participants, including 75 patients with CRS and 23 healthy controls.

[The importance of intranasal trigeminal event-related potentials test for patients with olfactory dysfunction].

To analyze the characteristics of trigeminal event-related potentials (tERPs) in different kinds of olfactory disorders (OD), and to evaluate the importance of tERPs for the patients with olfactory dysfunction. Clinical data of 314 patients with olfactory dysfunction from the Smell and Taste Clinics in Beijing Anzhen Hospital from 2015 to 2021 were retrospectively reviewed, including 158 males and 156 females, aging from 6 to 78 years. The control group consisted of healthy people from medical examination center, who were gender and age matched.

[Analysis of clinical characteristics in the patient with olfactory disorders].

To analyze the etiology and clinical features of patients with olfactory disorders （OD） , and to explore the importance of gustatory testing in patients with OD. Clinical data of 335 consecutive patients with OD who seek medical consultation in the smell and taste center from the year 2015 to 2021 was retrospectively analyzed. The clinical characteristics of patients with OD were analyzed thorough a structured interview of medical history, otolaryngologic examinations, olfactory tests（Sniffin' Sticks test） and gustatory function test（whole-mouth taste test）.

A novel irrigation device with superior nasal irrigation efficiency to the classic rinse bottle.

Background: The ability of saline irrigation to detach the mucous and the flow-limiting effect of the nasal valve has not been well explored. The objective of this study was to compare the removal efficiency of a novel irrigation device with an extended nozzle versus a classic rinse bottle.

Methods: Transparent casts of the unoperated sinonasal cavity were made by 3D printing.

Development of a novel centrifugal extraction device to collect the olfactory cleft mucus.

Background: Measuring olfactory cleft mucus biomarkers provides critical insights into the pathogenesis of the olfactory dysfunction.

Objectives: This study aimed to develop a novel centrifugal extraction device to collect the olfactory cleft mucus.

Material And Methods: The olfactory cleft mucus was collected from 18 patients with chronic rhinosinusitis (CRS) and 10 healthy controls using polyvinyl alcohol (PVA) sponges.

Development of an apparatus and procedure for evaluating the efficiency of nasal irrigation.

Background: Although different methods of nasal irrigation have been utilized, irrigation efficiency in nasal cavities has not been well assessed. The objective of this study was to develop an apparatus and procedure for evaluating the irrigation efficiency and to explore the optimal head position during irrigation.

Methods: Casts of the left sinonasal cavity from a healthy volunteer were made from high-resolution-computed tomography data using 3D printing with composite materials.

Clinical significance of the cognition-related pathogenic proteins in plasma neuronal-derived exosomes among normal cognitive adults over 45 years old with olfactory dysfunction.

Objectives: Exosomal Phospho-Tau-181(P-T181-tau), Total tau (T-tau), and amyloid-β peptide 42 (Aβ42) have been proved the capacity for the amnestic mild cognitive impairment (MCI) and the diagnosis of Alzheimer's disease (AD). This study aimed to explore the cognitive function and the levels of P-T181-tau, T-tau, and Aβ42 in neuronal-derived exosomes (NDEs) extracted from plasma in normal cognitive adults over 45 years old with olfactory dysfunction.

Methods: A cross-sectional survey of 29 participants aged over 45 was conducted.

Self-assembly and luminescence of trinuclear lanthanide based supramolecular circular helicates.

A series of trinuclear lanthanide circular helicates [LnL]Cl have been synthesized supramolecular subcomponent self-assembly. Photophysical studies demonstrate that the unique helical bis-tetradentate 1,29-dialdehyde ligand L could serve as an effective sensitizer for Sm, Eu, Nd and Yb ions exhibiting efficient characteristic fluorescence emission because of the shell-type blocking of the ligand, which makes them the first circular helicates exhibiting near-infrared lanthanide fluorescence.

Transmetalation and Demetallization for Open-Oyster-like Non-Ionic Cd(II) Macrocycles.

This work designed a nonionic extended dialdehyde 6,6'-(phenylazanediyl)dipicolinaldehyde () for constructing Schiff-base macrocyclic complexes with weaker metal-ligand interactions, so as to solve the long-standing challenges of transmetalation and demetallization in macrocyclic complexes. An enantiomeric pair of open-oyster-like 26-membered [2 + 2] Schiff-base macrocyclic dinuclear Cd(II) complexes (,-, ,-) could be obtained, having ,/,-1,2-diaminocyclohexane (,/,-) precursors, while Cu(II) ion template only resulted in a mononuclear Schiff-base Cu(II) acyclic complex (,-) accompanied by the half-oxidation of instead of expected [2 + 2] Cu(II) macrocyclic complexes. It is suggested that the weak oxidization capability of Cu(II) ion is responsible for the formation of ,- because X-ray photoelectron spectroscopy (XPS) for the solid powder of reaction mixture of direct Cu(II) ion template synthesis implies that both Cu(I) and Cu(II) species are present.

Construction and Photoluminescent Properties of Schiff-Base Macrocyclic Mono-/Di-/Trinuclear Zn Complexes with the Common 2-Ethylthiophene Pendant Arm.

A new flexible 2-ethylthiophene pendant-armed dialdehyde (Htdd) was reacted with 1,3-propanediamine, [( S, S),( R, R),(±)]-1,2-diaminocyclohexane, and 1,2-bis(2-aminoethoxy)ethane, giving birth to 36-membered [2 + 2] Schiff-base macrocyclic trinuclear Zn complex 1, 18-membered [1 + 1] mononuclear Zn macrocycles 2-4, chiral/racemic 34-membered [2 + 2] dinuclear Zn complexes 5-9, and 46-membered [2 + 2] dinuclear Zn macrocycles 10-12 via Zn ion template-assisted Schiff-base condensation. It is worth mentioning that the secondary template effects for nitrate and halide counterions have been observed in the 1,3-propanediamine involved imine condensation. In all [2 + 2] Zn macrocycles, dinuclear complexes 5-9 display a full-folded molecular conformation, while trinuclear complex 1 and dinuclear complexes 10-12 exhibit distinct half-folded structures in the presence or absence of intramolecular π-π stacking interactions between two phenolic rings of the dialdehyde component.

Schiff-base macrocyclic Zn complexes based upon flexible pendant-armed extended dialdehydes.

This Frontier article reviews diverse structures of Schiff-base macrocyclic ZnII complexes derived from a family of flexible pendant-armed extended dialdehydes via a preorganized synthetic strategy and the corresponding structure-determining factors, including primary cationic template effects and secondary complementary template effects. In addition, further post-modification and supramolecular self-assembly of Schiff-base ZnII macrocycles and their possible applications in a variety of areas have been discussed.

Transmetalation for Flexible Pendant-Armed Schiff-Base Macrocyclic Complexes Influenced by Halide Effects.

Three 46-membered [2 + 2] pendant-armed Schiff-base macrocyclic dinuclear Cd and Cu complexes (2a, 2b, and 3b) and one 23-membered [1 + 1] Cu macrocycle 4a were prepared from the template-directed condensation reactions between 1,2-bis(2-aminoethoxy)-ethane and extended Cl-dialdehyde in the presence of CdX and CuX (X = Cl and Br), in which halide effects play important roles in the organization of final macrocyclic complexes in addition to the dominant influence of metal cations. Transmetalation was intensively studied among these Cd and Cu complexes with large and flexible macrocyclic ligands, including two previously synthesized dinuclear Zn macrocycles (1a and 1b). Our results indicate that Zn → Cu and Cd → Cu transmetalation proceeds more quickly than that from Cd to Zn, and all the processes are found to be irreversible.

Polar Ketone-Functionalized Metal-Organic Framework Showing a High CO Adsorption Performance.

The incorporation of various functionalities into porous metal-organic frameworks (MOFs) represents an efficacious strategy to improving their gas adsorption properties. In this work, a carbonylated tetracarboxylic acid ligand (5,5'-carbonyldiisophthalic acid) was synthesized, and a ketone-functionalized MOF with exposed metal sites based on this ligand was formed successfully. Structural analysis reveals that the new MOF possesses channels decorated by the carbonyl groups and rhombicuboctahedral cages, with open Cu sites pointing toward the cage center.

Construction of Chiral [4 + 4] and [2 + 2] Schiff-Base Macrocyclic Zinc(II) Complexes Influenced by Counterions and Pendant Arms.

Chiral and racemic 68-membered [4 + 4] tetranuclear and 34-membered [2 + 2] dinuclear Schiff-base macrocyclic zinc(II) complexes 1-10 can be selectively synthesized based on the secondary template effects of counterions and pendant arms, when [(S,S), (R,R), (±)]-1,2-diaminocyclohexane precursors are first used to react with a pair of extended dialdehydes with different pendant arms via zinc(II) ion template-assisted imine condensation.

Two Types of Anion-Induced Reconstruction of Schiff-Base Macrocyclic Zinc Complexes: Ring-Contraction and Self-Assembly of a Molecular Box.

Two 46-membered [2 + 2] Schiff-base macrocyclic dinuclear Zn(II) complexes (1a and 1b) were investigated deeply by the postmodification strategy, and two types of supramolecular processes (ring-contraction and self-assembly) have been achieved after the addition of specific anions as stimulus for the equilibrium of Schiff-base macrocyclic complexes. Namely, in the presence of linear three-atom SCN(-), 1a was degraded into two 23-membered [1 + 1] Schiff-base macrocyclic complexes simultaneously (mononuclear Zn(II) complex 2 and dinuclear Zn(II) complex 3). In contrast, 1b was only transformed into the macrocyclic mononuclear complex 5.