Preferences for public health insurance coverage of new anticancer drugs: a discrete choice experiment among non-small cell lung cancer patients in China.

Background: Ensuring equal access to affordable, high-quality, and satisfied healthcare for cancer patients is a challenge worldwide. Our study aimed to investigate preferences for public health insurance coverage of new anticancer drugs among non-small cell lung cancer (NSCLC) patients in China.

Methods: We identified six attributes of new anticancer drugs and adopted a Bayesian-efficient design to generate choice scenarios for a discrete choice experiment (DCE).

Multidimensional morphological analysis of live sperm based on multiple-target tracking.

Manual semen evaluation methods are subjective and time-consuming. In this study, a deep learning algorithmic framework was designed to enable non-invasive multidimensional morphological analysis of live sperm in motion, improve current clinical sperm morphology testing methods, and significantly contribute to the advancement of assisted reproductive technologies. We improved the FairMOT tracking algorithm by incorporating the distance and angle of the same sperm head movement in adjacent frames, as well as the head target detection frame IOU value, into the cost function of the Hungarian matching algorithm.

3D nanofiber scaffolds from 2D electrospun membranes boost cell penetration and positive host response for regenerative medicine.

The ideal tissue engineering scaffold should facilitate rapid cell infiltration and provide an optimal immune microenvironment during interactions with the host. Electrospinning can produce two-dimensional (2D) membranes mimicking the extracellular matrix. However, their dense structure hinders cell penetration, and their thin form restricts scaffold utility.

Differential isocitrate dehydrogenase 1 and isocitrate dehydrogenase 2 mutation-related landscape in intrahepatic cholangiocarcinoma.

Background: Patients with intrahepatic cholangiocarcinoma (ICC) are prone to recurrence and poor survival. Targeted therapy related to isocitrate dehydrogenase (IDH) is an extremely important treatment. IDH1 and IDH2 mutations are generally thought to have similar effects on the tumor landscape.

The Relationship Between Changes of Left Heart Structure and Function and the Risk of Future Renal Damage in Patients with Essential Hypertension.

Purpose: In essential hypertensive patients, cardiac remodeling may be associated with the risk of renal damage in the future which can be reflected by the estimated glomerular filtration rate (eGFR). Through retrospective analysis, we evaluated the potential of cardiac remodeling based on echocardiographic measurements to predict the risk of renal damage in the future with hypertensive patients.

Methods: We retrospectively analyzed the relationship between the changes of left heart structure and function and renal damage for 510 patients with hypertension, who were diagnosed between 2016 to 2022.

Local chicken breeds exhibit abundant TCR-V segments but similar repertoire diversity.

The thymus-derived lymphocytes of jawed vertebrates have four T-cell receptor (TCR) chains that play a significant role in immunity. As chickens have commercial value, their immune systems require a great deal of attention. Local chicken breeds are an essential part of poultry genetic resources in China.

The association between polyunsaturated fatty acids and chronic obstructive pulmonary disease: a meta-analysis.

: Chronic obstructive pulmonary disease (COPD) is a common respiratory disease, and its development and prognosis are influenced by many nutrients. However, the relationship between polyunsaturated fatty acids (PUFAs) and COPD remains unclear. : This study searched all literature reports on PUFAs and COPD based on electronic databases from their inception up to October 2023.

Exploring the role of the gene in hypoxia adaptation in Tibetan pigs.

The gene, which is an actin-binding protein, is prevalent in eukaryotic cells and is abundantly present in various pathways associated with plateau hypoxia adaptation. Tibetan pigs, which have inhabited high altitudes for extended periods, provide an excellent research population for investigating plateau hypoxia adaptation. This study focused on Tibetan pigs and Yorkshire pigs residing in Nyingchi, Tibet.

Metal-organic framework-mediated siRNA delivery and sonodynamic therapy for precisely triggering ferroptosis and augmenting ICD in osteosarcoma.

The complex genomics, immunosuppressive tumor microenvironment (TME), and chemotherapeutic resistance of osteosarcoma (OS) have resulted in limited therapeutic effects in the clinic. Ferroptosis is involved in tumor progression and is regulated mainly by glutathione peroxidase 4 (GPX4). Small interfering RNA (siRNA)-based RNA interference (RNAi) can precisely target any gene.

Fatty Acid Metabolism: A New Perspective in Breast Cancer Precision Therapy.

Breast cancer has a special tumor microenvironment compared to other solid tumors, which is usually surrounded by a large number of adipocytes that can produce and secrete fatty acids and adipokines. Adipocytes have a remodeling effect on breast cancer lipid metabolism, while fatty acids and lipid droplets can make breast cancer cells more aggressive. Lipid metabolism, especially the synthesis of fatty acids, is an important cellular process for membrane biosynthesis, energy storage, and signal molecule production.

Effects of dietary supplement of ε-polylysine hydrochloride on laying performance, egg quality, serum parameters, organ index, intestinal morphology, gut microbiota and volatile fatty acids in laying hens.

Background: ε-polylysine hydrochloride (ε-PLH) is a naturally occurring antimicrobial peptide extensively utilized in the food and medical industries. However, its impact on animal husbandry remains to be further explored. Therefore, the present study aimed to determine the effect of ε-PLH on laying hens' health and laying performance.

Simultaneous magneto-dielectric transitions in a fluorescent Hofmann-type coordination polymer.

The design of magnetic molecular materials exhibiting multiple functions has garnered significant interest owing to their potential applications in molecular switches, sensors, and data storage devices. In this study, we synthesized a two-dimensional (2D) Fe-based Hofmann-type coordination polymer, namely {Fe(DPPE)[Ag(CN)]}·2EtOH (1), using a luminescent ligand 1,1-diphenyl-2,2-di(4-pyridylbiphenyl)ethylene (DPPE). Single-crystal structural analyses and magnetic measurements revealed a thermally induced spin crossover (SCO) with the transition temperature = 231 K.

Calcium sulfate-Cu delivery system improves 3D-Printed calcium silicate artificial bone to repair large bone defects.

There are still limitations in artificial bone materials used in clinical practice, such as difficulty in repairing large bone defects, the mismatch between the degradation rate and tissue growth, difficulty in vascularization, an inability to address bone defects of various shapes, and risk of infection. To solve these problems, our group designed stereolithography (SLA) 3D-printed calcium silicate artificial bone improved by a calcium sulfate-Cu delivery system. SLA technology endows the scaffold with a three-dimensional tunnel structure to induce cell migration to the center of the bone defect.

Molecular characterization of ferroptosis in soft tissue sarcoma constructs a prognostic and immunotherapeutic signature through experimental and bioinformatics analyses.

Ferroptosis regulators have been found to affect tumor progression. However, studies focusing on ferroptosis and soft tissue sarcoma (STS) are rare. Somatic mutation, copy number variation, reverse transcription-quantitative polymerase chain reaction (RT-qPCR) analysis, consensus clustering, differentially expressed genes analysis (DEGs), principal component analysis (PCA) and gene set enrichment analysis (GSEA) were used to identify and explore different ferroptosis modifications in STS.

g-CN/Ag@AgCl with Z-scheme heterojunction and Ag electron bridge for enhanced photocatalytic degradation of tetracycline wastewater.

Building Z-scheme heterojunctions with an electron bridge is a favored function for increasing photocatalytic activity. A facile approach for preparing g-CN/Ag@AgCl ternary heterojunctions by co-precipitation and photoreduction was established in this work. First, via co-precipitation, AgCl was modified on the surface of g-CN to create a broad contact area between AgCl and g-CN.

The hind information: Exploring the impact of physical damage on mask microbial composition in the aquatic environment.

Due to poor management and the lack of environmental awareness, lots of masks (an emerging form of plastic pollution) are discarded into the environment during the COVID-19, thereby jeopardizing the health of humans and the environment. Our study introduces a novel perspective by examining the impact of physical damage on the microbial composition of masks in the water environment. We focus on the variations in biofilm formation on each layer of both damaged and undamaged masks, which allows us to understand more about the biofilm on each layer and the significant changes that occur when masks are physically damaged.

[Effect of acupuncture on swallowing function for patients of Parkinson's disease with dysphagia].

Objective: To observe the effects of acupuncture on swallowing function and quality of life for patients with dysphagia in Parkinson's disease (PD).

Methods: A total of 60 patients of PD with dysphagia were randomly divided into an observation group (30 cases, 2 cases dropped off) and a control group (30 cases, 3 cases dropped off). The control group was given conventional medication therapy and rehabilitation training.

Manipulating fluorescence by photo-switched spin-state conversions in an iron(ii)-based SCO-MOF.

Manipulating fluorescence by photo-switched spin-state conversions is an attractive prospect for applications in smart magneto-optical materials and devices. The challenge is how to modulate the energy transfer paths of the singlet excited state by light-induced spin-state conversions. In this work, a spin crossover (SCO) Fe-based fluorophore was embedded into a metal-organic framework (MOF) to tune the energy transfer paths.

Regulating Magnetic Relaxations of Cyano-Bridged {Dy Mo } Systems by Tuning the N-Sites in β-Diketone Ligands.

Cyano-bridged 4d-4f molecular nanomagnets have re-called increasing research interests in molecular magnetism since they offer more possibilities in achieving novel nanomagnets with versatile structures and magnetic interactions. In this work, four β-diketone ligands bearing different substitution N-sites were designed and synthesized, namely 1-(2-pyridyl)-3-(3-pyridyl)-1,3-propanedione (HL ), 1,3-Bis (3-pyridyl)-1,3-propanedione (HL ), 1-(4-pyridyl)-3-(3-pyridyl)-1,3-propanedione (HL ), and 1,3-Bis (4-pyridyl)-1,3-propanedione (HL ), to tune the magnetic relaxation behaviors of cyano-bridged {Dy Mo } systems. By reacting with DyCl  ⋅ 6H O and K Mo(CN)  ⋅ 2H O, four cyano-bridged complexes, namely {[Dy[Mo (CN) ](HL ) (H O) ]} ⋅ 6H O (1), {[Dy[Mo (CN) ](HL )(H O) (CH OH)]}  ⋅ 2CH OH ⋅ 3H O (2), {[Dy[Mo (CN) ](HL )(H O) (CH OH)] ⋅ H O} (3), and {[Dy[Mo (CN) ](HL ) (H O) ]} ⋅ 2H O⋅CH OH (4) were obtained.

Does vitamin D have a potential role in precocious puberty? A meta-analysis.

: Precocious puberty, one of the common pediatric endocrine system diseases, has been related to reduced adult height, adverse psychological outcomes and long-term health consequences. Previous findings have found that low levels of vitamin D appear to be associated with the characteristics of precocious puberty such as early menarche. However, the effect of vitamin D on precocious puberty remains controversial.

Colossal Anisotropic Thermal Expansion through Coupling Spin Crossover and Rhombus Deformation in a Hexanuclear {Fe Fe } Compound.

Colossal and anisotropic thermal expansion is a key function for microscale or nanoscale actuators in material science. Herein, we present a hexanuclear compound of [(Tp*)Fe (CN) ] [Fe (Ppmp)] ⋅2 CH OH (1, Tp*=hydrotris(3,5-dimethyl-pyrazol-1-yl)borate and Ppmp=2-[3-(2'-pyridyl)pyrazol-1-ylmethyl]pyridine), which has a rhombic core structure abbreviated as {Fe Fe }. Magnetic susceptibility measurements and single-crystal X-ray diffraction analyses revealed that 1 underwent thermally-induced spin transition with the thermal hysteresis.

Effect of EVA Polymer and PVA Fiber on the Mechanical Properties of Ultra-High Performance Engineered Cementitious Composites.

In order to study the mechanical properties of ultra-high performance engineered cementitious composites (UHP-ECC) used for cable channel repair, orthogonal tests were carried out with four influencing factors, water binder ratio, silica fume, fly ash and mortar ratio, to obtain the optimum mix ratio of the cement paste. On this basis, the effects of ethylene-vinyl acetate (EVA) polymer and polyvinyl alcohol (PVA) fiber on the fluidity, flexural strength and compressive strength of UHP-ECC were studied, and the micromechanism was analyzed with SEM. The results show that the fluidity of UHP-ECC material prepared was 170-200 mm, which meets the requirements of working performance.

Soil nitrogen content and key functional microorganisms influence the response of wetland anaerobic oxidation of methane to trivalent iron input.

Trivalent iron (Fe)-dependent anaerobic oxidation of methane (Fe-AOM), which is mediated by metal-reducing bacteria, is widely recognized as a major sink for the greenhouse gas methane (CH), and is a key driver of the carbon (C) biogeochemical cycle. However, the effect of Fe addition on AOM in the present investigation is still ambiguous, and the mechanism is vague. In this study, we investigated the mechanism of changes in AOM response to Fe input at different wetlands by using laboratory incubation methods combined with molecular biology techniques.

Magnetic-field-dependent spin properties of divacancy defects in silicon carbide.

In recent years, spin defects in silicon carbide have become promising platforms for quantum sensing, quantum information processing and quantum networks. It has been shown that their spin coherence times can be dramatically extended with an external axial magnetic field. However, little is known about the effect of magnetic-angle-dependent coherence time, which is an essential complement to defect spin properties.