Upregulation of RCN2 accelerates tumor progression and indicates poor prognosis in OSCC.

Objective: Oral squamous cell carcinoma (OSCC) is a prevalent cancer of the head and neck region. However, the potential role of RCN2 in OSCC is currently not well understood.

Study Design: A series of molecular biology experiments were conducted to explore the mechanism by which RCN2 promotes OSCC growth through protein kinase A (PKA).

Computational screening of transition metal atom doped ZnS and ZnSe nanostructures as promising bifunctional oxygen electrocatalysts.

The design of bifunctional oxygen electrocatalysts showing high catalytic performance for the oxygen evolution reaction (OER) and oxygen reduction reaction (ORR) is of great significance for developing new renewable energy storage and conversion technologies. Herein, based on the first principles calculations, we systematically explored the electrocatalytic activity of a series of transition metal atom (Fe, Co, Ni, Cu, Pd and Pt)-doped ZnS and ZnSe nanostructures for OER and ORR. The calculated results revealed that Ni- and Pt-doped ZnS and ZnSe nanostructures exhibit promising electrocatalytic performance for both OER and ORR in comparison to the pristine ZnS and ZnSe nanostructures.

M2-type tumor-associated macrophages upregulated PD-L1 expression in cervical cancer via the PI3K/AKT pathway.

Background And Purpose: PD-1/PD-L1 inhibitors have become a promising therapy. However, the response rate is lower than 30% in patients with cervical cancer (CC), which is related to immunosuppressive components in tumor microenvironment (TME). Tumor-associated macrophages (TAMs), as one of the most important immune cells, are involved in the formation of tumor suppressive microenvironment.

Solvated Electrons Generated on the Surface of Na-SPHI for Boosting Visible Light Photocatalytic Hydrogen Evolution with Ultra-High AQE.

Enhancing the utilization of visible-light-active semiconductors with an excellent apparent quantum efficiency (AQE) remains a significant and challenging goal in the realm of photocatalytic water splitting. In this study, a fully condensed sulfur-doped poly(heptazine imide) metalized with Na (Na-SPHI) is synthesized by an ionothermal method by using eutectic NaCl/LiCl mixture as the ionic solvent. Comprehensive characterizations of the obtained Na-SPHI reveal several advantageous features, including heightened light absorption, facilitated exciton dissociation, and expedited charge transfer.

Enhancing the electrocatalytic performance of SnX (X = S and Se) monolayers for CO reduction to HCOOH transition metal atom adsorption: a theoretical investigation.

Exploring highly efficient, stable, and low-cost electrocatalysts for CO reduction reaction (CRR) can not only mitigate greenhouse gas emission but also store renewable energy. Herein, CO electroreduction to HCOOH on the surface of SnX (X = S and Se) monolayer-supported non-noble metal atoms (Fe, Co and Ni) was systematically investigated using first-principles calculations. Our results show that Fe, Co and Ni adsorbed on the surface of SnX (X = S and Se) monolayers can effectively enhance their electrocatalytic activity for CO reduction to HCOOH with low limiting potentials due to the decreasing energy barrier of *OOCH.

Enhanced CT combined with texture analysis for differential diagnosis of pleomorphic adenoma and adenolymphoma.

Objective: This study sought to evaluate the worth of the general characteristics of enhanced CT images and the histogram parameters of each stage in distinguishing pleomorphic adenoma (PA) and adenolymphoma (AL).

Methods: The imaging features and histogram parameters of preoperative enhanced CT images in 20 patients with PA and 29 patients with AL were analyzed. Tumor morphology and histogram parameters of PA and AL were compared.

Histogram analysis of ultrasonographic images in the differentiation of benign and malignant parotid gland tumors.

Objective: We evaluated the diagnostic value of histogram analysis (HA) using ultrasonographic (US) images for differentiation among pleomorphic adenoma (PA), adenolymphoma (AL), and malignant tumors (MT) of the parotid gland.

Study Design: Preoperative US images of 48 patients with PA, 39 patients with AL, and 17 patients with MT were retrospectively analyzed for gray-scale histograms. Nine first-order texture features derived from histograms of the tumors were compared.

Optimizing the band structure of sponge-like S-doped poly(heptazine imide) with quantum confinement effect towards boosting visible-light photocatalytic H generation.

Simultaneously manipulating the nanostructure and band structure of semiconductors for boosting the photocatalytic performance of photocatalyts is highly desirable. Herein, a series of hierarchical sponge-like S-doped poly(heptazine imide) (HS-SPHI) assembled by ultrathin nanosheets were successfully fabricated via a facile bottom-up supramolecular preassembly approach using melamine (MA) and trithiocyanuric acid (TTCA) as precursors. Benefiting from the synergistic effect of the S-doping and their unique hierarchical porous structure coupled with quantum confinement effect, the as-obtained HS-SPHIs are endowed with extended visible-light response, improved charge separation efficiency, enlarged specific surface area, and enhanced thermodynamic driving force for water reduction.

The diagnostic efficacy of ultrasonographically-based measurements of minimum and maximum fascia-tumor distance in differentiating superficial from deep lobe benign parotid tumors.

Objectives: The objective was to calculate the efficacy of ultrasonographically-based measurements of minimum and maximum fascia-tumor distance (MiFTD and MaFTD) of benign salivary gland tumors to identify tumor location in the superficial or deep lobe of the parotid gland.

Study Design: MiFTDs and MaFTDs were measured on pre-operative ultrasonographic images of 102 tumors. Tumor location was classified at surgery as superficial or deep based on relation to the facial nerve, with 74 tumors in the superficial lobe and 28 in the deep lobe.

Effects of different surgical treatments on children with ankyloglossia: protocol for a systematic review and meta-analysis.

Introduction: Ankyloglossia is a situation where the tongue tip cannot go beyond the mandibular incisor because the frenulum linguae is short. It could affect children's health by interfering with their ability to talk, breast feeding and dental development. The most effective measure to control ankyloglossia is the surgical method.

Differential diagnostic value of tumor morphology, long/short diameter ratio, and ultrasound gray-scale ratio for 3 parotid neoplasms.

Objective: The objective of this study was to evaluate the value of tumor morphology, long-to-short diameter ratio (L/S), and ultrasound gray-scale ratio (UGSR) in the differential diagnosis of 3 parotid neoplasms.

Study Design: Preoperative ultrasound images of 17 patients with a malignant tumor (MT), 48 patients with pleomorphic adenoma (PA), and 39 patients with adenolymphoma (AL) were analyzed for imaging features and gray-scale histograms. Tumor morphology, L/S, and UGSR of MT, PA, and AL were compared.

Efficient Linkable Ring Signature Scheme over NTRU Lattice with Unconditional Anonymity.

In cloud and edge computing, senders of data often want to be anonymous, while recipients of data always expect that the data come from a reliable sender and they are not redundant. Linkable ring signature (LRS) can not only protect the anonymity of the signer, but also detect whether two different signatures are signed by the same signer. Today, most lattice-based LRS schemes only satisfy computational anonymity.

Modulating the Electronic, Optical, and Transport Properties of CdTe and ZnTe Nanostructures with Organic Molecules: A Theoretical Investigation.

In this paper, we systematically investigated the electronic, optical, and transport properties of CdTe and ZnTe nanostructures before and after adsorption with benzyl viologen (BV) and tetrafluoro-tetracyanoquinodimethane (F4-TCNQ) organic molecules based on the first principles calculation. First, the band gaps of CdTe and ZnTe nanostructures obviously decrease after BV and F4-TCNQ adsorptions. Interestingly, the electronic property calculation shows that BV and F4-TCNQ can donate/accept electrons to/from the surface of CdTe and ZnTe nanostructures, leading to an effective n-/p-type doping, respectively.

Theoretical study of a p-n homojunction SiGe field-effect transistor covalent functionalization.

p-n homojunctions are superior to p-n heterojunctions in constructing nanoscale functional devices, owing to the excellent crystallographic alignment. We tune the electronic properties of monolayer siligene (SiGe) into p/n-type the covalent functionalization of electrophilic/nucleophilic dopants, using quantum transport calculations. It is found that the n-type doping effect of K atoms is stronger than that of benzyl viologen (BV) molecule on the surface of SiGe monolayer, owing to the strong covalent interaction.

Genome shuffling improved acid-tolerance and succinic acid production of .

Succinic acid is widely applied to chemical, pharmaceutical, food, and agricultural industries. With the rapid development of these industries, a great demand of succinic acid is required. The acid-tolerance and succinic acid production of strain were improved by using genome shuffling.

Memory phototransistors based on exponential-association photoelectric conversion law.

Ultraweak light detectors have wide-ranging important applications such as astronomical observation, remote sensing, laser ranging, and night vision. Current commercial ultraweak light detectors are commonly based on a photomultiplier tube or an avalanche photodiode, and they are incompatible with microelectronic devices for digital imaging applications, because of their high operating voltage and bulky size. Herein, we develop a memory phototransistor for ultraweak light detection, by exploiting the charge-storage accumulative effect in CdS nanoribbon.

An Ointment Consisting of the Phage Lysin LysGH15 and Apigenin for Decolonization of Methicillin-Resistant from Skin Wounds.

() is a common and dangerous pathogen that causes various infectious diseases. Skin damage, such as burn wounds, are at high risk of colonization and infection, which increases morbidity and mortality. The phage lysin LysGH15 exhibits highly efficient lytic activity against methicillin-resistant (MRSA) and methicillin-susceptible (MSSA) strains.

Acidic Mesoporous Zeolite ZSM-5 Supported Cu Catalyst with Good Catalytic Performance in the Hydroxysulfurization of Styrenes with Disulfides.

Development of highly active heterogeneous catalysts is an effective strategy for modern organic synthesis chemistry. In this work, acidic mesoporous zeolite ZSM-5 (HZSM-5-M), acidic-free mesoporous zeolite TS-1 (TS-1-M), and basic ETS-10 zeolite supported metal Cu catalysts were prepared to investigate their catalytic performances in the hydroxysulfurization of styrenes with diaryl disulfides. The effect of pore size and acidities of the supports, as well as the Cu species electronic properties of the catalysts on reaction activity were investigated.

TLR2 Mice Display Decreased Severity of Giardiasis Enhanced Proinflammatory Cytokines Production Dependent on AKT Signal Pathway.

infection is one of the most common causes of waterborne diarrheal disease in a wide array of mammalian hosts, including humans globally. Although numerous studies have indicated that adaptive immune responses are important for defense, however, whether the host innate immune system such as TLRs recognizes remains poorly understood. TLR2 plays a crucial role in pathogen recognition, innate immunity activation, and the eventual pathogen elimination.

Insights into water-mediated ion clustering in aqueous CaSO solutions: pre-nucleation cluster characteristics studied by ab initio calculations and molecular dynamics simulations.

The molecular structure of growth units building crystals is a fundamental issue in the crystallization processes from aqueous solutions. In this work, a systematic investigation of pre-nucleation clusters and their hydration characteristics in aqueous CaSO solutions was performed using ab initio calculations and molecular dynamics (MD) simulations. The results of ab initio calculations and MD simulations indicate that the dominant species in aqueous CaSO solutions are monodentate ion-associated structures.

Surface Charge Transfer Doping via Transition Metal Oxides for Efficient p-Type Doping of II-VI Nanostructures.

Wide band gap II-VI nanostructures are important building blocks for new-generation electronic and optoelectronic devices. However, the difficulty of realizing p-type conductivity in these materials via conventional doping methods has severely handicapped the fabrication of p-n homojunctions and complementary circuits, which are the fundamental components for high-performance devices. Herein, by using first-principles density functional theory calculations, we demonstrated a simple yet efficient way to achieve controlled p-type doping on II-VI nanostructures via surface charge transfer doping (SCTD) using high work function transition metal oxides such as MoO, WO, CrO, and VO as dopants.