Publications by authors named "Fei-fei Sun"
Background: This study explores the influence of family function on depression in older adults with chronic comorbidities and the mediating roles of cognitive fusion and coping styles.
Methods: The Family Adaptation Partnership Growth Affection and Resolve Index, Patient Health Questionnaire-9, Cognitive Fusion Questionnaire-Fusion, and Trait Coping Style Questionnaire were used to survey 448 community-dwelling older adults with chronic comorbidities. A mediation test was conducted using the Process 4.
Introduction: The trend of human migration to terrestrial high altitudes (HA) has been increasing over the years. However, no published prospective studies exist with follow-up periods exceeding 1 month to investigate the cardiac change. This prospective study aimed to investigate the changes in cardiac structure and function in healthy young male lowlanders following long-term migration to HA.
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- Spastic pelvic floor syndrome (SPFS) causes abnormal muscle contractions during defecation, leading to issues like constipation and anal blockage, which often requires manual assistance for bowel movements.
- The study aimed to examine the impacts of botulinum toxin A injections combined with biofeedback on anorectal pressure in patients with pelvic floor muscle spasm syndrome.
- Results showed a significant decrease in muscle tension and blood pressure after treatment, suggesting this approach is effective, but further research, including randomized controlled trials, is needed to confirm these findings.
Fluorine possesses distinctive chemical characteristics, such as its strong electron-withdrawing ability and small atomic size, which render it an invaluable asset in the design and optimization of pharmaceuticals. The utilization of fluorine-enriched medications for combating cancer has emerged as a prominent approach in medicinal chemistry and drug discovery, offering improved clinical outcomes and enhanced pharmacological properties. This comprehensive review explores the synthetic approaches and clinical applications of approved 22 representative fluorinated anti-cancer drugs from 2019 to present, shedding light on their historical development, brand names, drug target activity, mechanism of action, preclinical pharmacodynamics, clinical efficacy, and toxicity.
View Article and Find Full Text PDFFerroptosis has been shown to be involved in carbon tetrachloride (CCl)-induced acute liver injury (ALI). The mitochondrion-targeted antioxidant MitoQ can eliminate the production of mitochondrial reactive oxygen species (mtROS). This study investigated the role of MitoQ in CCl-induced hepatocytic ferroptosis and ALI.
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- The study focused on assessing the bioequivalence and pharmacokinetics of abiraterone acetate tablets, used to treat metastatic castration-resistant prostate cancer (mCRPC), in healthy Chinese volunteers.
- A randomized trial involving 36 volunteers tested both reference and test formulations while collecting blood samples to analyze drug concentration levels.
- Results indicated that both formulations demonstrated bioequivalence under fasting conditions, with the geometric mean ratios falling within acceptable limits for pharmacokinetic parameters.
Article Synopsis
- - Mitochondrial oxidative stress plays a significant role in liver damage caused by acetaminophen (APAP), and MitoQ, a coenzyme Q10 analog, acts as a strong antioxidant targeting mitochondria.
- - In experiments with mice and liver cells, oxidative markers increased rapidly after APAP treatment, showing liver injury signs like cell death and disrupted mitochondria structures.
- - MitoQ demonstrated a protective effect against APAP-induced liver injury by reducing protein nitration and lipid peroxidation, with its mechanism of action being partially reliant on the enzyme FSP1 and independent of GPX4.
Background: Immune-related long noncoding RNAs (IrlncRNAs) are recognized as important prognostic factors in a variety of cancers, but thus far, their prognostic value in pediatric rhabdoid tumor of the kidney (pRTK) has not been reported. Here, we clarified the associations between IrlncRNAs and overall survival (OS) of pRTK patients and constructed a model to predict their prognosis.
Methods: We accessed RNA sequencing data and corresponding clinical data of pRTK from the Therapeutically Applicable Research to Generate Effective Treatments (TARGET) database.
Objective: To explore whether there exist undiscovered transphyseal vasculature-canal compound structures in immature femurs and tibias, and reveal their potential oncological impact.
Methods: This investigation was divided into a morphological study and a clinical study. In the morphological part, a new-identified anatomic structure was investigated by using radiographical, anatomical, and histological methodologies.
This paper presents an experimental and analytical investigation on the performance of partial penetration welds used to adjoin steel plates in irregular shaped multicell concrete filled steel tubes. The experimental program of this study is designed based on an actual implementation of such members as mega columns in a super high rise building in China. A total of six specimens are designed with different plate arrangements for the purpose of testing the performance of the partial penetration welds at different locations of the specimen.
View Article and Find Full Text PDFObjective: Our objective was to evaluate the pharmacokinetics and bioequivalence of test and reference (JANUMET) formulations of sitagliptin phosphate/metformin hydrochloride tablets at a single dose of 50 mg/850 mg.
Methods: The study was a randomized, open-label, two-period, double-crossover trial. Volunteers under fasting (n = 24) and fed (n = 24) conditions were given a single oral dose of test or reference formulations of sitagliptin phosphate/metformin hydrochloride tablets 50 mg/850 mg.
Background: To compare the long-term therapeutic effects of stereotactic aspiration (SA), endoscopic evacuation (EE), and open craniotomy (OC) in the surgical treatment of spontaneous basal ganglia hemorrhage and explore the appropriate clinical indications for each technique.
Methods: Multiple-treatment inverse probability of treatment weighting (IPTW)-adjusted logistic regression analysis was performed to evaluate the therapeutic effects of these techniques. The primary and secondary outcomes were 6-month modified Rankin Scale (mRS) and mortality rates, respectively.
Article Synopsis
- The study investigated how the Tangshan Earthquake affected sleep quality in adults who experienced it as infants or fetuses, as well as the role of the CRHR1 gene polymorphism in this effect.
- A total of 556 participants were grouped based on their exposure to the earthquake, and sleep quality was measured using the Pittsburgh Sleep Quality Index (PQSI).
- Results showed that those exposed to the earthquake had a higher prevalence of sleep disturbances, particularly those with certain CRHR1 gene variations, indicating that both seismic stress and genetic factors contribute to sleep quality issues in adulthood.
Isolated metastasis of hepatocellular carcinoma in the right ventricle.
BMC Cardiovasc Disord
December 2019
Article Synopsis
- Isolated metastasis of hepatocellular carcinoma (HCC) to the right ventricle is extremely rare and often results in poor prognosis due to potential hemodynamic instability.
- A case study featuring a 63-year-old male with this condition demonstrated inflow obstruction caused by the cardiac mass and included a review of related research from 1980 to 2018.
- Accurate pre-operative assessment through multimodal imaging is crucial, and while palliative treatments can alleviate severe symptoms, there is no standardized treatment protocol currently available.
Purpose: Our purpose was to compare long-term survival outcomes and sequelae between child and adult nasopharyngeal carcinoma (NPC) in the era of intensity modulated radiation therapy.
Methods And Materials: Data on 285 patients with NPC aged ≤18 years at diagnosis and treated with intensity modulated radiation therapy between January 2004 and November 2016 were retrospectively reviewed. A propensity score matching method was adopted to screen matched adult patients with NPC at a ratio of 1:3.
Background: The study sought to determine the effects of earthquake on the working memory of adults who experienced earthquake either as infants or fetuses and also investigates whether earthquake exposure and corticotropin-releasing factor receptor 1 (CRHR1) variants rs242924 and rs7209436 interacted with each other in modulating working memory.
Methods: We enrolled subjects who experienced the Tangshan Earthquake as fetuses (group I) or infants (group II), as well as those who did not experience the earthquake (group III). Their working memory was measured using Brief Visuospatial Memory Test-Revised (BVMT-R) and Hopkins Verbal Learning Test-Revised (HVLT-R).
Background: Infantile hepatic hemangioma (IHH) is a rare endothelial cell neoplasm, which may be concurrent with severe complications and result in poor outcomes. Moreover, the coexistence of IHH and congenial heart disease is even rarer.
Case Presentation: We present a 10-day-old male born with IHH associated with patent ductus arteriosus (PDA), atrial septal defect (ASD) and pulmonary hypertension.
Article Synopsis
- A study involving 12 patients with severe haemophilia B aimed to evaluate the pharmacokinetics of nonacog alfa after administering a single dose of 50 IU/kg and to analyze the effect of varying sampling times on the drug's half-life.
- Blood samples were collected at multiple time points post-infusion, and the experiment found no adverse events or cases of FIX inhibitors among the participants.
- Results showed that extending the sampling duration to 96 hours provided a more accurate estimate of the drug's half-life (39.6 hours) compared to shorter observation periods (29.6 hours and 27.2 hours for 72 and 50 hours truncation, respectively).
Introduction: Brain metastasis is common in relapsed neuroblastoma patients, but the characteristics of brain metastasis remain largely unknown. This study aimed to investigate the status of brain metastasis with neuroblastoma in South China.
Methods: In this retrospective case-based study, 106 patients with stage 4 neuroblastoma from the Department of Pediatric Oncology in Sun Yat-sen University Cancer Center between January 2004 and May 2013 were included.
Purpose: To research the association between pre-treatment elevated platelet count and clinicopathologic characteristics in breast cancer (BC), as well as explore the relationship between pre-treatment elevated platelet count and HER2 status and prognosis of BC patients.
Materials And Methods: A retrospective cohort of BC patients who were newly diagnosed or treated by surgery only and had pathological detection results and platelet values in the Department of Oncology, the First Affiliated Hospital of Liaoning Medical College were enrolled from 1/1/2008 until 31/12/2009, and followed up until 31/12/2014. Age, thrombocyte parameters before chemotherapy and/or radiotherapy, immunohistochemical (IHM) indexes, and regional lymph node (LN) involvement and progression-free survival (PFS) were recorded.
For children with stage II testicular malignant germ cell tumors (MGCT), the survival is good with surgery and adjuvant chemotherapy. However, there is limited data on surgical results for cases in which there was no imaging or pathologic evidence of residual tumor, but in which serum tumor markers either increased or failed to normalize after an appropriate period of half-life time post-surgery. To determine the use of chemotherapy for children with stage II germ cell tumors, we analyzed the outcomes (relapse rate and overall survival) of patients who were treated at the Sun Yat-sen University Cancer Center between January 1990 and May 2013.
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- This study focused on primary central nervous system germ cell tumors (CNS-GCTs) in Chinese children and adolescents, highlighting their clinical characteristics and treatment results over a 10-year period from 2002 to 2012.
- Of the 57 patients analyzed, the majority were male, with a median age of 12.8 years; most had non-germinomatous germ cell tumors (NGGCTs) and localized disease.
- Results showed that patients who received multimodality therapies, like the PEB chemotherapy alongside surgery or radiotherapy, had significantly better survival rates compared to those who underwent monotherapy.
The SSU1 gene encoding a membrane sulfite pump is a main facilitator invovled in sulfite efflux. In Saccharomyce cerevisiae, various range of resistance to sulfite was observed among strains. To explore the evolution traits of SSU1 gene, the population data of S.
View Article and Find Full Text PDFObjective: To evaluate the efficacy of a modified NHL-BFM-90 protocol in childhood and adolescence with Burkitt lymphoma (BL) and diffuse large B-cell lymphoma (DLBCL).
Methods: A total of 138 de novo patients with BL and DLBCL were enrolled. All patients were stratified into low (R1), intermediate (R2) and high risk (R3) groups based on the stage, chemotherapy response and LDH level, and treated with a modified NHL-BFM 90 protocol.
Article Synopsis
- The study evaluated the safety of in vitro amplified HLA-haploidentical donor immune cell infusion (HDICI) in 12 children with various malignancies, primarily neuroblastoma, at Sun Yat-sen University Cancer Center between 2011 and 2012.
- Out of the patients, a significant majority showed positive responses to treatment; 7 of 9 with neuroblastoma achieved complete response, while some experienced mild side effects like fever and emotional changes, with no severe adverse events reported.
- The findings suggest that HDICI is a safe immunotherapy option for treating childhood cancers and indicate the need for further research into its efficacy.