Publications by authors named "Fei-Yang Zhang"
In recent years, considerable concerns have been raised regarding environmental pollution caused by water-soluble polymers (WSPs). Polyvinyl alcohol (PVA), used in the textile industry and in the manufacture of medical consumables, is one type of WSPs. After use, PVA is discharged and enters aquatic ecosystems, but most of it cannot be completely biodegraded in the environment.
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- Chronic exposure to interferon-γ (IFN-γ) in cancers leads to tryptophan shortage via the IDO-kynurenine pathway, which results in abnormal peptides being produced through ribosomal frameshifting and codon reassignment.
- In EBV-positive gastric cancer (GC), infiltrating lymphocytes secrete IFN-γ, increasing IDO1 expression and depleting tryptophan, which promotes the production of tryptophan-to-phenylalanine (W>F) substitutants.
- The mTOR/eIF4E signaling pathway plays a crucial role in this process, as inhibiting it can reduce W>F substitutant production and improve antigen presentation,
One-step harvest of high-purity light hydrocarbons without the desorption process represents an advanced and highly efficient strategy for the purification of target substances. The separation and purification of acetylene (CH) from carbon dioxide (CO) by CO-selective adsorbents are urgently demanded yet are very challenging owing to their similar physicochemical properties. Here, we employ the pore chemistry strategy to adjust the pore environment by immobilizing polar groups into an ultramicroporous metal-organic framework (MOF), achieving one-step manufacture of high-purity CH from CO/CH mixtures.
View Article and Find Full Text PDFBackground: Although the incidence of adenocarcinoma of the esophagogastric junction (AEG) has been increasing since the past decade, the proportion of AEG cases in two previous clinical trials (ACTS-GC and CLASSIC) that investigated the efficacy of adjuvant chemotherapy was relatively small. Therefore, whether AEG patients can benefit from adjuvant chemotherapy remains unclear.
Methods: Patients who were diagnosed with pathological stage II/III, Siewert II/III AEG, and underwent curative surgery at three high-volume institutions were assessed.
To compare the inhibition of LAG3-PD1 versus the inhibition of CTLA-4-PD1 in patients with previously untreated advanced melanoma. The individual participant data (IPD) were extracted from the KM plots using a graphical reconstructive algorithm. Log-rank, Cox proportional hazard model, Bayesian hierarchical model with time-varying hazard ratio (HR) effect, and restricted mean survival time (RMST) were performed to estimate survival benefits.
View Article and Find Full Text PDFBackground: We aimed to assess whether the Response Evaluation Criteria in Solid Tumors (RECIST)-based objective response rate (ORR), disease control rate (DCR) and progression-free survival (PFS) could serve as surrogate endpoints for overall survival (OS) in immune-oncology (IO) trials of advanced gastro-esophageal (GE) carcinoma.
Methods: Randomized controlled trials (RCTs) of IO that reported RECIST-based endpoints and OS in advanced GE carcinoma were screened. Surrogacy of endpoints for OS was assessed based on the correlation between endpoints with OS (arm-level), and between treatment effects on endpoints (trial-level).