Publications by authors named "Fei-Ping Li"
Objective: To investigate the value of CT radiomics features of meso-esophageal fat in the overall survival (OS) prediction of patients with locally advanced esophageal squamous cell carcinoma (ESCC).
Methods: A total of 166 patients with locally advanced ESCC in two medical centers were retrospectively analyzed. The volume of interest (VOI) of meso-esophageal fat and tumor were manually delineated on enhanced chest CT using ITK-SNAP.
Article Synopsis
- The study aimed to describe how nasopharyngeal carcinoma (NPC) spreads locally using MRI and sought to enhance the accuracy of clinical target volume (CTV) delineation for treatment.
- Research involved reviewing MRIs from 870 newly diagnosed NPC patients, categorizing tumors as either eccentric or central based on their growth patterns.
- Findings revealed that eccentric lesions primarily invade in one direction and have a low chance of affecting the opposite side, suggesting that routine radiation for the unaffected side may not be needed, while central lesions tend to spread more bilaterally.
A community-based prostate cancer screening program was conducted to assess the morbidity and associated factors for prostate cancer among the subpopulation of men aged ≥50 years in Taizhou, China. Taizhou Integrated Prostate Screening (TIPS) is a large, observational, population-based study of prostate cancer screening data based on serum prostate-specific antigen (PSA) concentrations. A pilot census of all male residents aged 50 years or older was conducted in Luqiao District, one of the field sites of the TIPS cohort in the city of Taizhou, Zhejiang.
View Article and Find Full Text PDFA lack of confidence on the vaccination drive hinders the management of the COVID-19 pandemic. We aimed to assess the antibody response to the SARS-CoV-2 vaccine among hospitalized patients in China. This case-control study was based on SARS-CoV-2 sero-surveillance during hospitalization.
View Article and Find Full Text PDFEndometrial mesenchymal stem cells (eMSCs) are undifferentiated endometrial cells with self-renewal, multidirectional differentiation and high proliferation potential. Nowadays, eMSCs have been found in a few species, but it has never been reported in endangered wild animals, especially the red panda. In this study, we successfully isolated and characterized the eMSCs derived from red panda.
View Article and Find Full Text PDFThis study is conducted to explore the association between health behaviors and the COVID-19 vaccination based on the risk compensation concept among health-care workers in Taizhou, China. We conducted a self-administered online survey to estimate the health behaviors among the staff in a tertiary hospital in Taizhou, China, from May 18 to 21 May 2021. A total of 592 out of 660 subjects (89.
View Article and Find Full Text PDFImpact of RET Screening on the Management of Multiple Endocrine Neoplasia Type 2A: 10 Years Experience and Follow-Up in Three Families.
Endocr Metab Immune Disord Drug Targets
May 2022
Article Synopsis
- - MEN 2A is primarily linked to a specific mutation (RET codon C634) and can lead to Medullary Thyroid Carcinoma (MTC), pheochromocytoma (PHEO), and hyperparathyroidism; early diagnosis and treatment are crucial for better outcomes.
- - A study of 32 family members found that 31.3% had the RET C634Y mutation, with significant differences in MTC diagnosis ages and tumor aggression based on whether symptoms were present or not.
- - The study concludes that proactive RET screening and careful surgical approaches improve the likelihood of successful treatment in MEN2A patients, recommending laparoscopic adrenal-sparing surgery before total thyroidectomy for PHEO cases.
Women with polycystic ovary syndrome (PCOS) are characterized by endocrine disorders accompanied by a decline in oocyte quality. In this study, we generated a PCOS mice model by hypodermic injection of dehydroepiandrosterone, and metformin was used as a positive control drug to study the effect of pachymic acid (PA) on endocrine and oocyte quality in PCOS mice. Compared with the model group, the mice treated with PA showed the following changes (slower weight gain, improved abnormal metabolism; increased development potential of GV oocytes, reduced number of abnormal MII oocytes, and damaged embryos; lower expression of ovarian-related genes in ovarian tissue and pro-inflammatory cytokines in adipose tissue).
View Article and Find Full Text PDFArticle Synopsis
- Mesenchymal stem cells (MSCs) have the ability to self-renew and differentiate into various cell types, making them valuable for therapeutic use and conserving genetic diversity in endangered species.
- The study focused on isolating and characterizing MSCs from the bone marrow of red pandas, revealing they share characteristics with MSCs from other species and express important stem cell markers.
- These red panda MSCs not only showed potential for extensive growth in the lab but also for differentiation into specific cell types (osteogenic, adipogenic, neuron-like), highlighting their importance for biodiversity preservation and future research on endangered species.
Fine particulate matter (PM) has an adverse effect on reproductive function, in particular causing reduced male reproductive function, but relatively few studies have directly targeted its effects on female reproduction. To investigate the effects of PM exposure on female reproduction, we exposed female mice to PM by intratracheal instillation for 28 days, and evaluated apoptosis of ovarian granulosa cells and oocytes and the quality embryos after insemination. Our results showed increased numbers of apoptotic granulosa cells and oocytes after exposure to elevated concentrations of PM, which had adverse effects on female fertility via compromising embryo development and quality.
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- Graphene nanomaterials, particularly graphene quantum dots (GQDs), show promise in biomedical applications due to their exceptional properties, but concerns exist regarding their potential adverse effects on biological systems.
- In vitro studies revealed that high dosages of GQDs hindered the maturation of mouse oocytes, causing issues like decreased polar body extrusion rates and damage to mitochondrial structures, likely due to DNA damage and reactive oxygen species accumulation.
- In vivo experiments indicated that while high GQD exposure during pregnancy affected fetal growth, it did not impact the long-term health or reproductive success of subsequent generations, suggesting a need for continued research on GQDs for safe medical use.
Di(n-butyl) phthalate (DBP) is extensively used in industrial applications as plasticizer and stabilizer and its presence in the environment may present health risks for human. Previous studies have demonstrated its mutagenic, teratogenic, and carcinogenic ability. However, its effect on mammalian oocyte maturation remains unknown.
View Article and Find Full Text PDFSKAP2 (Src kinase-associated phosphoprotein 2), a substrate of Src family kinases, has been suggested to be involved in actin-mediated cellular processes. However, little is known about its role in mouse oocyte maturation. In this study, we thus investigated the expression, localization, and functions of SKAP2 during mouse oocyte asymmetric division.
View Article and Find Full Text PDFArticle Synopsis
- - KIF2A, a kinesin-13 family protein, is important for spindle assembly during meiotic division in mouse oocytes, but its specific role was previously unclear.
- - The study showed that KIF2A is expressed at crucial stages of meiosis, localizing in the germinal vesicle and spindle, and co-localizes with α-tubulin when spindle assembly occurs.
- - Depletion of KIF2A leads to severe issues in spindle assembly and chromosome alignment, ultimately causing problems in cytokinesis and a reduced rate of polar body extrusion, suggesting its critical role in meiosis regulation.
Methoxychlor (MXC) is used worldwide against insects and other pests. This organochlorine pesticide acts as a xenoestrogen, promotes oxidative stress, and is considered cytotoxic and genotoxic, causing abortions and stillbirths in females. Mechanistically related estrogens and oxidants affect oocyte meiosis, so we investigated the effects of MXC on mouse oocyte meiotic maturation.
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- The study aimed to explore how effective intravoxel incoherent motion (IVIM) diffusion-weighted MRI is at distinguishing nasopharyngeal carcinoma (NPC) from lymphoma.
- 102 patients (82 with NPC and 20 with lymphoma) underwent pretreatment MRI, measuring several parameters such as apparent diffusion coefficient (ADC) and perfusion fraction (f).
- Results showed that NPC had significantly higher values in most parameters compared to lymphoma, indicating that IVIM DWI can effectively differentiate between these two types of tumors.
Objectives: To investigate the value of quantitative dynamic contrast-enhanced MRI (QDCE-MRI) and diffusion-weighted MRI (DW-MRI) in differentiating nasopharyngeal carcinoma (NPC) from lymphoma.
Methods: We retrospectively analysed the data from 102 patients (82 with NPC and 20 with lymphoma) who underwent pre-treatment QDCE-MRI and DW-MRI on a 1.5-T MR unit.
Background: To investigate the value of intravoxel incoherent motion (IVIM) diffusion-weighted magnetic resonance imaging (DW-MRI) in predicting the early response to induction chemotherapy (IC) and chemoradiotherapy (CRT) in nasopharyngeal carcinoma (NPC).
Methods: Fifty NPC patients who received IC and CRT underwent an IVIM DW-MRI on a 1.5-Tesla MRI scanner.
Article Synopsis
- The study aimed to assess the feasibility and outcomes of retroperitoneoscopic surgery in patients who previously underwent open retroperitoneal surgeries.
- Ten patients were evaluated, with conditions including recurrent renal cysts and nonfunctional kidneys, and all underwent successful retroperitoneoscopy procedures.
- Results showed that surgeries were completed safely with manageable blood loss, a reasonable hospital stay, and no postoperative complications, suggesting retroperitoneoscopy is a viable option for selected patients with a history of related surgeries.
Background: As the third-generation tension-free tape for female stress urinary incontinence (SUI), tension-free vaginal tape (TVT)-Secur has decreased the common complications associated with TVT and tension-free vaginal tape-transobturator (TVT-O), such as bladder perforation and obstruction of the bladder outlet; but its efficacy and persistence were still controversial. The aim of this study was to prospectively evaluate and compare the postoperative efficacy and complication at different follow-up time.
Methods: Patients with SUI, who underwent TVT-Secur treatment in two hospitals from October 2008 to October 2009, were selected.
Introduction And Hypothesis: The purpose of the study was to evaluate and compare the clinical values of tension-free vaginal tape (TVT), tension-free vaginal tape-transobturator (TVT-O), or tension-free vaginal tape-Secur (TVT-Secur) as treatment for female stress urinary incontinence.
Methods: The pre-operative and 1-year post-operative follow-up protocols for patients who were treated with serial mid-urethral tension-free tape procedures in two hospitals from October 2008 to December 2009 were prospectively studied. These patients were randomly allocated to TVT, TVT-O, or TVT-Secur.
[A comparative study of nephrectomy and radical nephrectomy for renal cell carcinoma].
Zhonghua Yi Xue Za Zhi
April 2010
Article Synopsis
- - The study compared the effectiveness and safety of nephrectomy versus radical nephrectomy in treating renal cell carcinoma (RCC) in 134 patients without metastasis.
- - Results showed that nephrectomy had shorter operating times and less blood loss, with fewer complications, although both procedures had similar long-term outcomes regarding metastasis and survival rates.
- - The conclusion suggests that for patients without metastasis, nephrectomy is an effective and safer option due to its advantages in recovery and reduced procedural risks.
[Preventive strategies and causes of common complications of ureteroscopy].
Zhonghua Yi Xue Za Zhi
December 2009
Objective: To discuss the causes of common complications of ureteroscopy and how to prevent them.
Methods: A total of 768 cases of common complications of ureteroscopy were retrospectively analyzed from February 2004 to February 2009.
Results: The intra-operative complications were failed entry (n = 6, 0.