Publications by authors named "Fei-Lin Qu"
Article Synopsis
- This study explores how certain genomic alterations in breast cancer might be connected, influencing both the biological characteristics of the cancer and the effectiveness of treatments.
- Researchers analyzed data from large cohorts (873 and 4,405 patients) and tested ideas using patient-derived models.
- Key findings link specific genetic alterations to treatment responses, suggesting that understanding these interactions could lead to better, personalized treatment strategies for patients.
Ipsilateral breast tumor recurrence after breast-conserving surgery: insights into biology and treatment.
Breast Cancer Res Treat
November 2023
Despite modern surgical and irradiation techniques, ipsilateral breast tumor recurrence (IBTR) accounts for 5-15% of all cancer recurrence in women treated with breast conservative treatment. Historically, this event has been treated definitively with salvage mastectomy and completion axillary clearance. However, many local recurrences are small and without nodal involvement at presentation.
View Article and Find Full Text PDFPurpose: Salvage mastectomy is traditionally recommended for patients who developed ipsilateral breast tumor recurrence (IBTR) in light of previous breast irradiation. However, it remains controversial whether surgical axillary staging (SAS) is necessary for IBTR patients with negative nodes. This study aimed to evaluate the oncologic safety of omitting SAS for IBTR.
View Article and Find Full Text PDFObjective: To determine if there is an association between total lipid intake, saturated fatty acid (SFA), Poly- and Mono-Unsaturated Fatty Acid (PUFA and MUFA) and cholesterol intake and breast cancer risk.
Materials And Methods: We conducted a systematic review of the literature and a meta-analysis following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. We included all cohort and case-control studies published up to December 2020 with subgroup analysis according to menopausal status.
Background: Loco-regional recurrences (LRR) following breast-conserving surgery (BCS) remain a heterogeneous class of disease that has significant variation in its biological behavior and prognosis.
Methods: To delineate the spatiotemporal patterns of LRR after BCS, we analyzed the data of 4325 patients treated with BCS from 2006 to 2016. Clinico-pathological and treatment specific factors were analyzed using the Cox proportional hazards model to identify factors predictive for LRR events.