Two New Cembranoids from the Soft Coral Sinularia sp. with Antioxidant Activity.

The chemical investigation of Et2O (Diethyl ether)-soluble partition of the acetone extract of soft coral Sinularia sp. collected off Ximao Island, has led to the isolation and characterization of two new cembranoids (1 and 2), along with one known related analogue (3). The structures and absolute configurations of 1 and 2 were elucidated through extensive spectroscopic analysis and time-dependent density functional theory-electronic circular dichroism (TDDFT-ECD) calculations.

Molecular characteristics and risk factor analysis of Staphylococcus aureus colonization put insight into CC1 colonization in three nursing homes in Shanghai.

Research indicates that Staphylococcus aureus colonization in the elderly with predisposing risks is associated with subsequent infection. However, the molecular epidemiology and risk factors for S. aureus colonization among residents and staff in nursing homes (NHs) in China remain unclear.

The Superior Ability of Human BDCA3 (CD141) Dendritic Cells (DCs) to Cross-Present Antigens Derived From Necrotic Lung Cancer Cells.

Dendritic cells (DCs) play a key role in initiating and regulating the immune responses to pathogens, self-antigens, and cancers. Human blood DCs comprise a family of different subsets: plasmacytoid DCs (pDCs) and CD16, CD1c/BDCA1, and BDCA3 (CD141) myeloid DCs and possess different phenotypes and functional characteristics. Lung cancer is the most common cancer, with the highest morbidity and mortality in the world.

Molecular Epidemiology and Antimicrobial Resistance of in Adult Patients in Shanghai, China.

The serotype and antimicrobial resistance of in adult patients have changed due to the application of antimicrobials and type b (Hib) vaccine worldwide. However, the epidemiologic characteristics of in Shanghai are still unavailable. To determine the serotype distribution, antimicrobial resistance and multilocus sequence type (MLST) of in adult patients in Shanghai.

Human inflammatory dendritic cells in malignant pleural effusions induce Th1 cell differentiation.

Dendritic cells are crucial for the initiation and regulation of immune responses against cancer and pathogens. DCs are heterogeneous and highly specialized antigen-presenting cells. Human DCs comprise several subsets with different phenotypes and functional properties.

[Preliminary observation on imbalance degree of impedance in extracellular fluid of cells in the twelve meridians in healthy subjects].

Objective: To calculate the imbalance degree (IBD) of left-right meridian (IBD-LRM), IBD of exterior-interior meridian (IBD-EIM) and IBD of hand-foot meridians (IBD-HFM) of impedance in extracellular fluid of cells in twelve meridians of healthy subjects, so as to provide foundation for meridian diagnosis.

Methods: A total of 31 healthy volunteers were enrolled and bioelectrical impedance spectroscopy (BIS) was applied. The constant current (from 1 to 100 kHz, 200 μA) was connected into the bilateral twelve meridians through two excitation electrodes with a distance of 10 cm.

Serotype Distribution, Antimicrobial Susceptibility, and Multilocus Sequencing Type (MLST) of From Adults of Three Hospitals in Shanghai, China.

, a main causative agent associated with invasive and non-invasive infection in elderly population, is a major global health problem. After pneumococcal conjugate vaccines (PCV) and pneumococcal polysaccharide vaccines (PPV) were introduced, the distribution of serotypes has changed. There was currently limited data on epidemiology and status of antimicrobial resistance of in Shanghai.

Clinical value of MLH1-negative circulating tumor cells in lung cancer patients.

Circulating tumor cells (CTCs) serve as valuable biomarkers. However, MutL homolog 1 (MLH1)-negative CTCs and their clinical significance in lung cancer are nearly unknown.Here, bioinformatic analysis of MLH1 expression and its clinical significance was conducted using the Oncomine, Ualcan, and Kaplan-Meier plotter websites.

[Comparison of Extracellular and Intracellular Fluid Distribution Between Stomach Meridian or Gallbladder Meridian and Their Neighboring Tissues of Lower Leg in Healthy Volunteers].

Objective: To compare differences of extracellular fluid impedance (Re) and intracellular fluid impedance (Ri) between the Stomach(ST) Meridian or Gallbladder(GB) Meridian and their neighboring non-meridian sites of the left lower leg at the same level, so as to explore the distribution characteristics of body fluid in the meridian.

Methods: Sixteen healthy volunteers were enrolled in the present study. The Re and Ri were detected by using Ag/AgCl electrodes and a digital lock-in amplifier.

Understanding Qi Running in the Meridians as Interstitial Fluid Flowing via Interstitial Space of Low Hydraulic Resistance.

Qi, blood and the meridians are fundamental concepts in Chinese medicine (CM), which are components of the human body and maintain physiological function. Pathological changes of qi, blood and meridians may lead to discomfort and disease. Treatment with acupuncture or herbal medicine aims to regulate qi and blood so as to recover normal function of the meridians.

Antimicrobial susceptibility and molecular epidemiology of clinical Enterobacter cloacae bloodstream isolates in Shanghai, China.

Background: Enterobacter cloacae is a major nosocomial pathogen causing bloodstream infections. We retrospectively conducted a study to assess antimicrobial susceptibility and phylogenetic relationships of E. cloacae bloodstream isolates in two tertiary university-affiliated hospitals in Shanghai, in order to facilitate managements of E.

[Preliminary Observation on Imbalance Degree of Blood Perfusion on the Twelve -source Points in Healthy Subjects].

Objective: To lay a foundation for meridian diagnosis by measuring the blood perfusion (BP) on -source points of twelve meridians and calculating the normal range of imbalance degree (IBD) of left and right meridian (IBD-LRM), IBD of exterior-interior meridian (IBD-EIM) and IBD of hand-foot of the same name meridians (IBD-HFM) in healthy subjects.

Methods: BP at -source points of twelve meridians was measured on 31 healthy volunteers by a Laser Doppler Line Scanner (LDLS). BP distribution and IBD-LRM, IBD-EIM, IBD-HFM were calculated.

Marked response to nab-paclitaxel in EGFR mutated lung neuroendocrine carcinoma: A case report.

Rationale: Lung cancer is the leading cause of cancer-related death in the world. Tyrosine kinase inhibitors (TKIs), which target mutated epidermal growth factor receptor (EGFR), have been the first-line treatment of late-stage lung adenocarcinoma harboring EGFR mutation. EGFR mutations are mostly identified in lung adenocarcinoma.

Antimicrobial Resistance and Molecular Characterization of Causing Childhood Pneumonia in Shanghai.

or methicillin-resistant (MRSA) is a major pathogen causing pneumonia among children. To estimate the prevalence and molecular properties of in children pneumonia in Shanghai, China, 107 hospitalized children with pneumonia from two children's hospitals from January 2014 through June 2015 were studied. isolates from the respiratory specimens were characterized by antimicrobial susceptibility, typing, toxin genes, multilocus sequence typing (MLST), , and SCCmec typing.

The Resistance Phenotype and Molecular Epidemiology of in Bloodstream Infections in Shanghai, China, 2012-2015.

(.pneumoniae) is a common nosocomial pathogen causing bloodstream infections. Antibiotic susceptibility surveillance and molecular characterization will facilitate prevention and management of bloodstream infections.

Molecular Epidemiology of Staphylococcus aureus among Patients with Skin and Soft Tissue Infections in Two Chinese Hospitals.

Background: Staphylococcus aureus is one of the predominant causes of skin and soft tissue infections (SSTIs), but limited data were available regarding the characterization of S. aureus from SSTIs patients in Jiangsu Province in China. We aimed to investigate the molecular epidemiology of S.

Lung adenocarcinoma harboring concomitant SPTBN1-ALK fusion, c-Met overexpression, and HER-2 amplification with inherent resistance to crizotinib, chemotherapy, and radiotherapy.

Crizotinib is a multi-targeted tyrosine kinase inhibitor (TKI) with activity against mesenchymal-epithelial transition factor (MET) and anaplastic lymphoma kinase (ALK). However, the concomitant oncogenic drivers may affect the sensitivity of crizotinib. Herein, we present a 69-year-old never-smoker Chinese male with advanced lung adenocarcinoma harboring concomitant spectrin beta non-erythrocytic 1 (SPTBN1)-ALK fusion, c-Met overexpression, and human epidermal growth factor receptor-2 (HER-2) amplification with inherent resistance to crizotinib, chemotherapy, and radiotherapy.

Prevalence and Molecular Epidemiology of Staphylococcus aureus among Residents of Seven Nursing Homes in Shanghai.

Background: Residents in nursing homes (NHs) always represent potential reservoirs for Staphylococcus aureus and methicillin-resistant S. aureus (MRSA). To our knowledge, there is no epidemiological information up till now that describes the prevalence and molecular characteristics of S.

Characterization of Staphylococcus aureus Isolated from Non-Native Patients with Skin and Soft Tissue Infections in Shanghai.

Background: Staphylococcus aureus is one predominant cause of skin and soft-tissue infections (SSTIs), but little information exists regarding the characterization of S. aureus from non-native patients with SSTIs in China.

Methods: In this study, we enrolled 52 non-native patients with S.

Molecular characterization of Staphylococcus aureus from surgical site infections in orthopedic patients in an orthopedic trauma clinical medical center in Shanghai.

Background: Staphylococcus aureus or methicillin-resistant Staphylococcus aureus (MRSA) is a leading cause of surgical site infections (SSIs). The aim of our study was to characterize molecularly S. aureus isolates from SSIs in orthopedic patients in Shanghai, China.

[Clinical application of modified casting post with zirconia crown in restoration of anterior teeth].

Purpose: To evaluate the clinical effect of modified casting post with zirconia crown in restoration of anterior teeth.

Methods: A total of 45 anterior teeth (32 patients) were treated with modified gold-alloy post-cores with zirconia crowns. All roots were greatly tilted to the labial side.

Color fringe-projected technique for measuring dynamic objects based on bidimensional empirical mode decomposition.

A triple-frequency color fringe-projected technique is presented to measure dynamic objects. Three fringe patterns with a carrier frequency ratio of 1:3:9 are encoded in red, green, and blue channels of a color fringe pattern and projected onto an object's surface. Bidimensional empirical mode decomposition is used for decoupling the cross talk among color channels and for extracting the fundamental frequency components of the three fringe patterns.

Relationship between plasma cathepsin S and cystatin C levels and coronary plaque morphology of mild to moderate lesions: an in vivo study using intravascular ultrasound.

Background: Cathepsin S and its endogenous inhibitor cystatin C are implicated in the pathogenesis of atherosclerosis, especially in the plaque destabilization and rupture leading to acute coronary syndrome. However, whether circulating cathepsin S and cystatin C also change in association with coronary plaque morphology is unknown yet.

Methods: We recruited 98 patients with unstable angina (UA, n = 6) or stable angina (SA, n = 2) who had a segmental stenosis resulting in > 20% and < 70% diameter reduction in one major coronary artery on coronary angiography.